Fondazione Policlinico Universitario Agostino Gemelli Irccs

This study tests whether an automated fluid management system can help maintain stable blood pressure in high-risk patients during colorectal surgery. Researchers will compare the amount of fluids given and how well blood pressure is controlled. The goal is to reduce episodes of …

This study compares three ways to help people with severe low oxygen levels breathe easier: a helmet that pushes air, a CPAP mask, and high-flow oxygen through the nose. The goal is to see which method reduces the need for a breathing tube. About 1,200 adults with acute respirato…

This study tests a gentle laser treatment for people with central serous chorioretinopathy (CSC), an eye condition where fluid builds up under the retina. It includes 36 adults whose condition did not improve after six months of medication. The goal is to see if the laser helps r…

This study tests if injections of a substance made from umbilical cord blood (called platelet-rich plasma) can slow the worsening of dry age-related macular degeneration (AMD), a common cause of vision loss in older adults. About 36 people aged 65 and older with dry AMD in both e…

This study tests whether giving multiple fecal microbiota transplants (FMT) works better than a single infusion to cure recurrent C. difficile infection in people with ulcerative colitis. About 64 adults with active colitis and repeat C. diff infections will receive either one or…

This study looks at whether a 12-month home-based aerobic exercise program can help improve thinking skills and slow cognitive decline in people with Parkinson's disease who also have mild memory or thinking problems. Researchers will measure changes in movement, mood, and blood …

This study looks at two medications for acromegaly, a condition where the body makes too much growth hormone. The goal is to see which drug better prevents spine fractures, a common and painful problem. About 120 adults whose acromegaly is not well-controlled will take either Pas…

This study tests whether injecting a special solution made from umbilical cord blood and platelet-rich plasma into the eye can slow or stop the worsening of dry age-related macular degeneration (AMD), a common cause of vision loss in older adults. About 36 people aged 65 and olde…

This study tests whether fecal transplants from specially selected 'superdonors' can help people with mild-to-moderate ulcerative colitis achieve remission. About 42 adults with a recent diagnosis will receive either a superdonor transplant or a placebo via colonoscopy and capsul…

This study tests whether a fecal transplant from a healthy donor can clear a type of antibiotic-resistant bacteria (CRE) from the gut. About 52 adults with CRE in their gut will receive either a real or placebo transplant via colonoscopy. The goal is to see if the transplant can …

This study looks at whether DNA from a routine Pap test can find early signs of ovarian cancer in women with high-risk gene mutations. Researchers will compare DNA changes in Pap smears with tissue samples from preventive surgery. If successful, this could lead to a simple screen…

This study compares two methods to find cancer cells in lymph nodes removed during surgery for early-stage endometrial cancer. About 1,922 women will be randomly assigned to have their lymph nodes checked by either the standard ultrastaging method or the newer OSNA method. The go…

This study aims to create a new, non-invasive stool test that looks at gut bacteria to detect colorectal cancer and advanced polyps. Researchers will collect stool samples from 1,006 people aged 50-74 who are part of a national screening program and have had a positive initial st…

This study looks at whether a non-invasive ultrasound technique that measures spleen stiffness can accurately detect dangerous liver blood pressure and high-risk varicose veins in the esophagus. Researchers will enroll 450 adults with advanced chronic liver disease. Participants …

This study is testing whether a computer model can predict if a woman carries a harmful BRCA gene mutation just by looking at ultrasound images of her healthy ovaries. Over 6,400 women will participate, and the goal is to create a simple, non-invasive screening tool. If successfu…

This study is testing a new, non-invasive scanning method that measures spleen stiffness to better detect and monitor advanced liver scarring in people with fatty liver disease (MASLD). Researchers will follow 500 adult patients with confirmed or suspected advanced liver disease …

This study looks at whether a ketogenic (low-carb, high-fat) diet helps people with rectal cancer stick to their diet plan during radiation therapy. About 194 participants will be randomly assigned to either a ketogenic diet or a standard diet. The main goal is to see how well pa…

This study tests whether doing mental and physical tasks at the same time—like walking while counting—can improve balance and thinking in frail older adults. Eighty people aged 65-90 with chronic movement or memory problems will receive remote training via video or phone. The goa…

This study looks at whether the antidepressant vortioxetine can help people who have both depression and migraine. About 31 adults with moderate to severe depression and episodic migraine will take vortioxetine for 12 weeks. Researchers will track changes in mood, anxiety, and mi…

This study looks at how fecal microbiota transplantation (FMT) changes the gut bacteria of 20 people with repeat C. diff infections. FMT is known to work well, but why it works is not fully understood. Researchers will analyze stool samples before and after treatment to track mic…

This study looks at whether a blood test that detects tiny bits of tumor DNA (called ctDNA) can help doctors better manage gastrointestinal cancers like pancreas, colon, and bile duct cancer. About 100 adults with these cancers will provide blood and stool samples to see if certa…

This study looks at whether women with advanced ovarian cancer who are at low risk for complications can safely avoid a temporary colostomy bag after part of their bowel is removed during surgery. The goal is to see if a 'no-stoma' approach is feasible without increasing dangerou…

This study creates miniature, 3D copies of liver tumors from 150 patients to test how well different treatments work. Researchers will also study the tumor's environment and the connection between the gut and liver. The goal is to better understand why some patients respond to th…

This study looks at 50 people with ovarian cancer that came back quickly after treatment. Researchers will track their health and survival to learn more about who benefits from further therapies. The goal is to improve how doctors classify and care for these patients.

This study looks at how blood flow changes in the right kidney and main gut artery during heart surgery that uses a heart-lung machine. The goal is to see if these changes are linked to kidney damage after surgery. About 92 adults having heart surgery will take part, and no new t…

This study aims to create a questionnaire in Italian that measures how much people who have had their spleen removed know about preventing infections. A panel of 20 healthcare experts will use a structured method called Delphi to decide which questions to include. The final tool …

This study looks at the immune cells inside pituitary tumors to understand how they behave. Researchers will analyze tumor samples from 60 adults who are having surgery to remove their pituitary tumor. The goal is to find new markers that could help guide future treatments like i…

This study surveys about 264 Italian hospitals that treat endometrial cancer to find out how often they use POLE testing. POLE testing helps doctors know which patients have a very low risk of cancer returning and may not need extra treatment. The goal is to understand current pr…

This study aims to find better ways to detect lung scarring (interstitial lung disease) early in people with autoimmune connective tissue diseases. Researchers will analyze tiny particles in the blood and use AI to examine lung scans from 200 participants. The goal is to identify…

This study looks at bone density in 100 pregnant women (ages 30-45) during their third trimester, comparing those carrying one baby versus twins. Researchers use a special bone scan and questionnaires to see if twin pregnancies lead to greater bone loss. The goal is to better und…

This study looks at how fat buildup in the pancreas (pancreatic steatosis) relates to diabetes and metabolic syndrome. Researchers will use a special ultrasound to measure the fat and compare it with blood sugar and other health markers in 100 adults. The goal is to better unders…

This study looks at the gut microbiome (the collection of bacteria in your digestive system) in people who developed irritable bowel syndrome after an infection. Researchers will compare their gut bacteria to those who had an infection but no IBS, and to healthy people. The goal …

This study tests whether artificial intelligence (AI) can predict how much of a patient's advanced ovarian cancer can be removed during surgery. Researchers will train AI to analyze images from a camera inserted into the belly (laparoscopy) to help doctors decide the best treatme…

This study looks at how certain drugs that affect the body's natural endocannabinoid system change the way bladder muscle contracts. Researchers will collect a small piece of healthy-looking bladder tissue from 65 adults having bladder cancer surgery. In the lab, they will test h…

This study compares three different facemasks used with a breathing machine (noninvasive ventilation) in 20 people whose lungs are not removing carbon dioxide well. The goal is to see which mask helps the diaphragm work less while clearing CO2 more effectively. Results will guide…

This study tracks 40 adults who develop bile duct narrowing after a liver transplant. Doctors will use endoscopy to place plastic stents and see how well this clears the blockage. The goal is to learn which treatments work best for this complication.

This study is for people with colorectal cancer that has spread only to the liver. Researchers want to see if using MRI scans can help doctors better decide who should have surgery to remove liver tumors. About 100 adults will take part, and the study will track how often surgery…

This study aims to better predict serious complications like heart disease and kidney failure in people who develop diabetes after a kidney transplant. Researchers will use advanced testing and artificial intelligence to find patterns in blood, urine, and kidney tissue. 120 adult…

This study tests a new Italian program designed to help teenagers with epilepsy transition from pediatric to adult healthcare. Researchers will compare teens who go through the program with those who receive standard care, measuring how many attend their first adult clinic appoin…

This study follows 34 adults with FSHD for one year to see how their breathing muscles change over time. Researchers will use ultrasound and breathing tests to measure diaphragm function. The goal is to find better ways to detect and track breathing problems in FSHD.

This study tests a new ultrasound method called dynamic contrast-enhanced ultrasound (D-CEUS) to see if it can measure how well a type of radiation therapy (PRRT) works in people with advanced neuroendocrine tumors of the pancreas or gut. About 30 adults will get D-CEUS scans bef…

This study looks at how the shape of the palate (roof of the mouth) changes in 36 growing children with a cross-bite after treatment with a rapid palate expander. The children are grouped by their facial growth pattern (high, normal, or low angle). Researchers use 3D scans and de…

This study aims to gather health data from 10,000 women in Italy who carry BRCA1 or BRCA2 gene mutations, which increase the risk of breast and ovarian cancers. By collecting information over time, researchers hope to better understand where these mutations are most common and im…

This study looks at how common mild depression is in people who have had their first heart attack. Researchers will follow 100 patients for a year to see if these mild symptoms affect recovery, heart health, and quality of life. The goal is to better understand the connection bet…

This study tests whether an artificial intelligence system can help doctors better manage blood pressure and fluid levels during complex ovarian cancer surgery. The approach aims to reduce complications like kidney injury and fluid buildup in the lungs. About 52 adults scheduled …

This study aims to gather detailed information from 10,000 people with endometrial cancer across Italy. Researchers will look at how the cancer's molecular and clinical features affect disease-free survival and overall survival. The goal is to create a comprehensive database to b…

This study aims to better understand cervical mucus, a fluid that helps sperm travel and protects the female reproductive tract. Researchers will use infrared spectroscopy to find biomarkers that could help diagnose or predict reproductive problems. They will compare healthy wome…

This study looks at whether a short teaching session helps people who have had their spleen removed understand their higher risk for serious infections and the importance of vaccines. About 100 adults will get one-on-one education during a hospital stay. Researchers will measure …

This study looks at a specific gene change (called hMLH1 hypermethylation) in stomach cancer to understand why it happens and how it affects treatment. Researchers will study 245 patients who had stomach cancer surgery to find links between lifestyle, diet, and this gene change. …

This study will collect ultrasound images from 25,000 women during routine exams to create a large digital library. The images will be used to train doctors and develop artificial intelligence tools for better diagnosis of gynecological conditions. Participants include healthy wo…

This study aims to better understand the physical causes of certain patterns seen on lung ultrasound images in people with interstitial lung disease or COPD. Researchers will compare ultrasound findings with CT scans in 25 patients to link artifacts to specific lung changes. The …

This study aims to understand how exposure to heavy metals and pollutants affects people with metal allergies compared to healthy individuals. Researchers will measure metals in blood and urine, perform skin patch tests, and analyze breathing and blood markers. The goal is to ide…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can detect ovarian cancer coming back earlier than current methods like CT scans or CA-125 blood tests. About 30 women with advanced ovarian cancer will give blood samples over time after their initial tr…

This study aims to collect detailed information about 1000 adults in Italy who have advanced (stage IV) lung cancer at the time they are first diagnosed. Researchers will look at patients' backgrounds, symptoms, imaging scans, and tumor samples to better understand the disease. N…

This study looks for biological markers in people with pancreatic cysts (IPMN) to better predict which ones are likely to become cancer. By analyzing tissue and blood samples from 3,600 participants, researchers hope to improve risk assessment and guide personalized treatment. Th…

This study looks at autoimmune encephalitis, a condition where the immune system attacks the brain, causing rapid confusion and dysfunction. Researchers want to understand why some patients have known antibodies while others test negative, and they aim to discover new antibodies …

This study tracks 20 adults with chronic hepatitis delta (a serious liver infection) who are starting a new drug called bulevirtide. Researchers want to see how the drug changes the gut's bacteria and bile acids over 48 weeks, and how those changes relate to inflammation and live…

This study looks at how people with obesity feel about their quality of life after a less invasive stomach procedure called endoscopic vertical gastroplasty (GVE). Researchers will interview 20 Italian adults who had the procedure at least six months ago. The goal is to understan…