Fondazione Policlinico Universitario Agostino Gemelli Irccs

This study observes 300 adults with metastatic colorectal cancer who are receiving a combination of two drugs (fluoropyrimidine and bevacizumab). Researchers are tracking how long patients live and how long the cancer stays under control. The goal is to gather real-world data on …

This study is testing a drug called cenobamate in 30 adults with autoimmune epilepsy, a condition where the immune system attacks the brain and causes seizures that often don't respond to standard treatments. The goal is to see if cenobamate can reduce seizure frequency by at lea…

This study looks at a simple two-step blood test to find primary biliary cholangitis (PBC) earlier in women aged 40 and older. PBC is a chronic liver disease that often has no symptoms at first, leading to late diagnosis. The test automatically checks for specific antibodies when…

This study is testing whether two markers in the blood, PLIN2 and RAB14, can accurately diagnose non-alcoholic steatohepatitis (NASH) and advanced liver scarring. Researchers will analyze blood samples from 828 people with NASH, type 2 diabetes, or obesity. If successful, this ap…

This study tests a special pouch made from the small intestine to help people who have had their entire stomach removed due to cancer. The goal is to reduce dumping syndrome—a common problem causing nausea, sweating, and diarrhea after eating—and improve nutrition and quality of …

This study tests two types of nerve blocks to manage pain after lung surgery. 28 adults having lung tumor removal will receive either a Serratus Posterior Superior Intercostal Plane block or an Intercostal Nerve block. The goal is to see which block provides better pain relief, r…

This study is for 40 adults with a confirmed genetic diagnosis of FSHD, a muscle disease that causes progressive weakness. Researchers will use MRI scans to see which muscles are most affected and combine that with 3D motion capture to analyze how people walk and move. The goal i…

This study looks at whether a blood test that detects tiny bits of tumor DNA (ctDNA) can help doctors decide who needs extra treatment after ovarian cancer surgery. Researchers will analyze stored blood samples from 50 patients taken before and after surgery. The goal is to see i…

This study looks at whether using a special camera called optical coherence tomography (OCT) during heart procedures helps doctors decide if and how to treat blocked arteries. Over 3,000 adults with various heart conditions are being followed to see if OCT guidance leads to fewer…

This study looks at whether thin slices of ovarian tumors grown in a lab can predict how well a patient will respond to chemotherapy. Researchers will test drugs on these slices and compare the results to the patient's actual treatment outcome. If successful, this approach could …

This study will give the Takeda dengue vaccine to 30 healthy adults aged 18-65 to learn how their T-cells (a type of immune cell) respond. The goal is to find markers that show whether the vaccine protects against all four types of dengue virus. This is a research study, not a tr…

This study aims to find out how often Charles Bonnet Syndrome (CBS) occurs in people with vision loss from conditions like macular degeneration or glaucoma. CBS causes complex visual hallucinations in people who are otherwise mentally healthy. Researchers will use questionnaires …

This study is testing a new way to care for people with rare diseases. It brings together specialists, advanced lab tests, and better data sharing to help diagnose patients faster and improve their overall care. The study involves 136 participants with conditions like mitochondri…

This study tests a new camera-based system called HERO that can measure heart rate, breathing, oxygen levels, blood pressure, body position, and even pain expressions without touching the patient. Researchers will check if the system's readings match standard hospital monitors in…

This study tests a simple, 15-minute neurological exam for babies up to 24 months old to find early signs of brain or nerve problems. Researchers will check if the exam works well in 300 infants. The goal is to help doctors identify at-risk children sooner so they can get the rig…

This study is testing a questionnaire to see how well it measures self-care in people with idiopathic pulmonary fibrosis (IPF). Researchers are adapting a tool originally designed for COPD patients. About 156 adults with IPF will take part. The goal is to give doctors and patient…

This study looks at how many adults in hospitals and long-term care homes need palliative care on a specific day (November 11). Researchers will check about 3,000 people for symptoms like pain, mobility issues, and other signs of serious illness. The goal is to find gaps in care …

This study checks if a set of thinking and memory tests usually done in person can be given remotely with the help of an examiner. Researchers will compare results from in-person and computer-based versions in 14 adults aged 50-90 with mild dementia. The goal is to make these ass…

This study is testing a new genetic test (called Gersom panel) in 4,000 people with breast, ovarian, or colorectal cancer. The goal is to see if the test can accurately find inherited genetic risks and tumor mutations that might guide treatment choices. Participants provide blood…