Fondazione Policlinico Universitario Agostino Gemelli Irccs

This study tests whether a new oral iron supplement (Sucrosomial iron) can treat iron deficiency anemia in pregnant women as effectively as intravenous (IV) iron, but with fewer side effects and lower cost. About 82 women in their second or third trimester with mild to moderate a…

This study will follow 200 people with HIV who are already virally suppressed to see how many stay on a long-acting injectable treatment (cabotegravir and rilpivirine) given every 2 months instead of daily pills. The goal is to measure how many continue the shots without stopping…

This early study tests if injecting a person's own fat-derived stem cells into the upper intestine is safe and can improve blood sugar control in type 2 diabetes. The goal is to help the body respond better to insulin and manage the disease long-term. Fifteen adults with type 2 d…

This early-stage study aims to develop a personalized treatment for children with syndromic craniosynostosis, a group of rare genetic disorders where skull bones fuse too early. The approach uses a nano-engineered gel to deliver custom genetic medicine directly to the affected ar…

This study tests a new treatment for people with bile leaks that won't heal after standard procedures. Doctors will take a small sample of bile duct tissue during surgery, grow it into mini bile ducts (organoids) in the lab, and then inject them into the leak site. The goal is to…

This pilot study tests whether a daily dietary supplement containing EGCG, folic acid, vitamin B12, and hyaluronic acid can help men with HPV clear the virus and support genital health. About 34 couples where the male partner has HPV and the female partner does not will be split …

This study tests whether a daily dietary supplement containing EGCG (from green tea), vitamin B12, hyaluronic acid, and folic acid can help men clear an HPV infection and support natural defenses in the genital tract. The study involves 96 participants (48 couples) where the male…

This study looks at whether a non-invasive heart ultrasound (transthoracic echocardiography) can accurately rule out infective endocarditis, a serious heart infection. Researchers will compare results from 350 adults who also received a more invasive probe-down-the-throat ultraso…

This study explores whether a special ultrasound technique (dynamic contrast-enhanced ultrasound) can accurately diagnose a rare liver condition called porto-sinusoidal vascular disorder (PSVD) without needing a liver biopsy. Researchers will compare ultrasound images from 100 pe…

This study looks at whether a non-invasive ultrasound test can accurately diagnose coronary artery issues in people with stable chest pain (angina) who have no major blockages. Researchers will compare results from the ultrasound with those from an invasive test that uses medicat…

This study looks at whether a special ultrasound and a spleen stiffness test can safely measure high blood pressure in the liver (portal hypertension) without a needle. About 107 adults with liver cirrhosis will get both the standard invasive test and the new ultrasound methods. …

This study tests a new way to use contrast-enhanced ultrasound (CEUS) to see if liver cancer treatment (ablation) worked completely. Researchers will compare CEUS results with standard CT or MRI scans in 200 adults. If accurate, this method could reduce the need for radiation or …

This study looks at new methods to find early signs of glaucoma, a leading cause of blindness. About 60 adults with glaucoma or high eye pressure will get advanced eye scans and vision tests. The goal is to catch damage sooner and improve current diagnosis.

This study compares a newer, gentler surgical tool (piezoelectric) with the standard tool (rotary bur) for removing dead jaw bone caused by certain medications. About 34 adults with stage 1 or 2 medication-related jaw osteonecrosis will be randomly assigned to one of the two surg…

This study aims to develop and test a questionnaire that helps decide which breast cancer patients truly need to come to the hospital for a check-up during their treatment. The goal is to reduce unnecessary visits, saving patients time and stress, while still catching any importa…

This study tests whether neurofeedback, a type of brain training, can reduce muscle and joint pain in people with inflammatory bowel disease (IBD). About 80 adults with IBD and chronic pain will use a special device to learn how to control their brain activity. The goal is to see…

This study tests whether a daily oral supplement containing collagen peptides and other ingredients can improve quality of life for women with genitourinary syndrome of menopause (GSM), which includes vaginal dryness, pain, and urinary incontinence. About 43 menopausal women will…

This study compares two laparoscopic hysterectomy methods (total removal vs partial removal of the uterus) in 500 women with benign conditions like fibroids or endometriosis. The goal is to see which approach leads to better quality of life and fewer complications over three year…

This study looks at how well a daily pill called relugolix combination therapy works for reducing endometriosis-related pain over 24 weeks in everyday medical practice. About 33 women aged 18-50 with confirmed endometriosis and moderate to severe pain will take part. The goal is …

This study tests whether four weekly counseling sessions before lung cancer surgery can lower anxiety and depression. About 138 adults awaiting lung cancer surgery will be split into three groups: those who get the counseling, those who refuse it, and healthy volunteers. Research…

This study compares two types of weight-loss surgery for people with severe obesity: robot-assisted and standard laparoscopic gastric bypass. Researchers want to see which approach leads to fewer complications, shorter hospital stays, and lower costs. About 512 adults will take p…

This study tests whether a dietary supplement called GenesiDol can reduce joint and muscle pain in people with inflammatory bowel disease (IBD), like Crohn's disease or ulcerative colitis. About 40 adults with persistent pain will take the supplement for 8 weeks. The goal is to s…

This study will follow 75 adults who need a root canal (first-time or repeat) at a hospital dental clinic. Researchers will check healing, pain, and tooth survival for up to 5 years. The goal is to see how well these treatments work in a hospital setting and if health conditions …

This study looks at whether a special heart ultrasound technique, called speckle tracking, can better predict survival and complications after mitral valve surgery compared to the current standard method. Researchers will follow 300 adults with severe mitral regurgitation who are…

This study will measure two proteins, SCUBE-1 and SCUBE-3, in the blood of women with polycystic ovary syndrome (PCOS) and compare them to healthy women. The goal is to see if these proteins are linked to inflammation and future heart problems. About 56 women aged 18-35 will take…

This study checks if a newer, cheaper DNA sequencing machine (MGI) works as well as the current standard (Illumina) for finding gene changes linked to hereditary cancers like breast, ovarian, and Lynch syndrome. Researchers will compare results from both machines using the same D…

This observational study will measure IL-6 and lactate levels in the blood of 160 full-term pregnant women and their newborns. Researchers want to see if these levels can help identify early signs of fetal infection or inflammation, especially when combined with heart rate patter…

This study looks at whether a thorough geriatric assessment before liver surgery (hepatectomy) can reduce major complications and improve recovery in patients aged 70 and older with liver cancer. Researchers will follow 242 participants to see if this personalized, multidisciplin…

This study looks at how a class of diabetes drugs called SGLT2i affects the balance between the 'fight or flight' and 'rest and digest' nervous systems in people with type 2 diabetes. Researchers will monitor heart rate patterns in 150 adults who also have heart failure, chronic …

This study looks at whether a structured training program helps radiologic technologists (the staff who run CT and MRI scans) safely place IVs for contrast dye. It involves 9 technologists and adult patients getting contrast scans. Researchers will measure how well the training w…

This study tests whether artificial intelligence (AI) can accurately predict the type of ovarian cancer and how well surgery will go by analyzing videos from a diagnostic laparoscopy. Researchers will enroll 100 adults with advanced ovarian cancer to see if the AI can match the f…

This study follows 500 people who recently had a stroke or mini-stroke to see how well they take their prescribed cholesterol-lowering medications and whether they reach their LDL cholesterol targets. Researchers will also track any new strokes or side effects over 90 days. The g…

This study asks women with gynecologic cancers if they would be interested in receiving long chemotherapy infusions at night instead of during the day. About 200 patients will fill out an anonymous online survey to share their preferences and concerns. The goal is to see if a nig…

This study will analyze blood proteins in 24 adults with generalized myasthenia gravis (MG) who are starting treatment with ravulizumab. The goal is to find protein changes that show how well the treatment is working and whether the nerve-muscle connection is healing. By identify…

This study looks at a new way to give recommended vaccines to adults with chronic diseases or weakened immune systems. Doctors will offer vaccines during hospital visits, admissions, or at discharge. The goal is to see how many patients accept and complete their vaccines, and to …

This study tests a new questionnaire called PET that measures how patients feel about their telemedicine visits. Researchers will ask 200 adults with conditions like IBD or heart rhythm problems about their experience. The goal is to make sure the questionnaire is reliable and ca…

This study will check if preserving the jawbone right after a tooth extraction helps with placing dental implants later. About 50 adults who need this procedure will be followed in a hospital setting. The goal is to see how much bone is kept and how well the implants work over ti…

This study looks at how different levels of pressure from a breathing machine affect the heart in people with moderate-to-severe acute respiratory distress syndrome (ARDS). Researchers will test three different pressure settings in 20 adults to see how lung collapse or overstretc…

This study looks at how often blood thinners are given to adults who are receiving palliative care in the hospital. Researchers want to understand current prescribing habits because there are no clear guidelines. The study will observe 410 patients and does not involve any new tr…

This study brings together 10 experts in heart health, personalized medicine, and digital technology to develop practical recommendations for using wearable devices (like smartwatches) and polygenic risk scores (a type of genetic test) to prevent heart disease. The goal is to agr…

This study tests whether remote motivational interviewing (coaching via video calls) can improve self-care in 124 adults with idiopathic pulmonary fibrosis (IPF). Participants will use digital tools to learn better disease management, with researchers tracking changes in self-car…

This study surveys 300 doctors from Italian medical societies to understand how they decide whether to continue or stop blood thinners in patients receiving palliative care. No drugs are given; instead, doctors answer questions about made-up patient cases. The goal is to learn ab…

This study looks at whether people with oral lichen planus (a chronic mouth condition) have a higher risk for heart problems and blood clots. Researchers will measure natural anticoagulant levels and antiphospholipid antibodies in 55 adults over one year. The goal is to understan…

This study aims to validate the Stroke Mimics Score, a tool that uses information collected when a patient arrives at the emergency room to help doctors quickly tell the difference between a real stroke and other conditions that mimic stroke symptoms. Researchers will enroll 1,00…

This study looks at 98 women with severe endometriosis affecting the bowel who need surgery. Researchers will compare standard transvaginal ultrasound with a newer method—ultrasound done during surgery—to see which better measures the size and depth of the disease. The goal is to…

This study looks at 100 adults with chronic pancreatitis or who had part of their pancreas removed. Even though they take enzyme pills, they still have stomach pain, bloating, or diarrhea. Researchers will use simple breath tests to check if an overgrowth of bacteria in the small…

This study looks at different types of surgery that aim to treat cervical adenocarcinoma while preserving a woman's ability to have children. Researchers will review past studies and their own patient data to compare how well each surgery controls the cancer and allows for succes…

This study looks at bacteria living inside breast tumors and compares them to bacteria in nearby healthy tissue, urine, and stool. Researchers want to see if these bacteria differ across breast cancer types and if they relate to how the cancer behaves. The study involves 240 wome…

This study looks at whether children with thin gums are more likely to have crowded teeth. Researchers will examine 180 children aged 5-16 to measure gum thickness and tooth crowding. The goal is to help dentists plan better treatments and prevent gum problems later in life.

This study will follow 100 people aged 30 to 70 who need surgery to remove bone tumors and then have reconstruction using special modular or 3D-printed implants. The goal is to see how well these custom implants work in terms of function, quality of life, and complications. The r…

This study tracks 300 adults with aortic disease to see how their condition impacts quality of life, fatigue, mental health, and ability to work. Researchers will measure changes over 12 months. The goal is to better understand these effects and help design care that supports pat…

This study uses donated human bodies to test new, less invasive ways to perform brain and spine surgery. Researchers will measure how much space each method creates and how well surgeons can see. The goal is to improve surgical training and make future surgeries safer. No patient…

This study will follow 20 patients who need dental implants in a hospital setting, many of whom have other health conditions or take medications. Researchers will measure bone loss around the implants and track how well the implants and replacement teeth hold up over time. The go…

This study looks at whether a simple chest ultrasound can help doctors predict how serious a respiratory infection is in children. Researchers will check if the ultrasound pattern can tell who needs to be hospitalized, admitted to the ICU, or needs extra breathing support. The go…

This study aims to better understand the mental health and thinking problems that often come with cancer. Researchers will follow 2,000 cancer patients, some with psychiatric disorders, and their family members to see how these issues change over time. The goal is to improve how …

This study looks at how weight-loss surgery affects the way people sense and interpret signals from their own bodies, like hunger and fullness. Researchers will follow 300 adults with severe obesity before and up to two years after surgery. The goal is to understand how these cha…

This study looks at how different skin cancer specialists (dermatologists, oncologists, surgeons, and radiation therapists) classify and treat basal cell carcinoma, the most common skin cancer. Researchers will show 20 doctors the same patient cases to see if their decisions vary…

This study will check if certain substances in the blood can predict heart damage in children and teens who had chemotherapy with anthracyclines. Researchers will compare blood test results and heart scans from 40 childhood cancer survivors to those from healthy kids. The goal is…

This study looks at whether injecting the blood thinner enoxaparin into the arm or the belly works better for preventing dangerous blood clots in people with severe obesity (BMI over 40). About 80 adults will take part, and researchers will measure drug levels in the blood to see…

This study is developing a questionnaire to measure how well people with inflammatory bowel disease (IBD) take care of themselves. Researchers will interview 275 patients to identify key self-care behaviors, then test the questionnaire's accuracy. The goal is to give doctors a be…

This study will look at 120 pregnant women with high blood pressure to see if certain ultrasound scans and blood tests can predict who will develop severe preeclampsia. The goal is to find better ways to identify women at highest risk for serious complications for both mother and…

This study will check if tiny plastic particles (microplastics) are present in the pancreas of 10 people having surgery for pancreatic disease. Researchers will also look for links between these particles and metabolic problems like diabetes. The goal is to gather first evidence,…

This study looks at how early, symptom-free hardening of the arteries (atherosclerosis) might be connected to thinking and memory problems. Researchers will use painless scans and thinking tests in 1,000 adults—some with heart disease and some without. The goal is to better under…

This study aims to collect information from 686 people with confirmed or suspected tuberculosis at a hospital in Italy. Researchers will use this data to create a simple risk score that helps doctors quickly decide who needs to be isolated and who does not. The goal is to improve…

This study looks at whether weight and height estimated by nurses or reported by patients are accurate compared to actual measurements in older adults admitted to the hospital. The goal is to see how these differences affect nutritional assessments, which rely on correct body mea…

This study aims to find out if simple, inexpensive blood tests can predict how well patients recover after surgery for a joint infection following hip or knee replacement. Researchers will follow 200 adults for at least 12 months after their surgery. The goal is to identify marke…

This study aims to discover new reasons why blood clots form in people with heart disease, diabetes, and other illnesses. Researchers will analyze blood samples from 200 patients with carotid artery narrowing to measure markers of oxidative stress and clotting factors. The goal i…

This study looks at why some baby or adult teeth fail to come in properly. Researchers will examine 50 patients to find better ways to diagnose the cause, including checking for a specific gene linked to a genetic form of the problem. The goal is to help doctors tell apart differ…

This study looks at 2,500 adults with liver scarring (cirrhosis) or high blood pressure in the liver (portal hypertension) to find out how often bleeding happens during planned medical procedures. Current blood tests don't predict bleeding well, so researchers will track patients…

This study looks at whether moving nurses between different heart-care units every two months helps them learn more and feel less burned out. About 86 nurses will take part, with some rotating and others staying in place. Researchers will measure skills, job satisfaction, and wor…

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and remote monitoring to see which patients respond best to treatment and which have complications. The goal is to fin…

This study looks at two ways of using breathing machines in patients with severe lung injury (ARDS). It compares a method that lets patients breathe on their own with one that fully controls breathing, to see which causes less lung damage. Twenty adults in the ICU will be tested …

This study will look at 25 adults with MOGAD, a rare disease affecting the brain and nerves, to find out how often headaches happen and what they are like. Researchers will collect information from medical records and follow patients over time. The goal is to better understand he…

This study looks at how mothers and fathers feel about the father being present or absent during a planned cesarean section. Researchers will interview 30 couples in Rome after the birth to understand their emotions, expectations, and support from hospital staff. The goal is to l…

This study looks at 400 adults without known heart or liver disease to understand how fat around the heart and belly is linked to early signs of heart disease, diabetes, and fatty liver. Participants will have non-invasive tests like ultrasound and blood work. The goal is to find…

This study checks if surgeons can tell key details about ovarian cancer by looking at images from a camera inside the belly. About 70-80 surgeons will review pictures from 50 patients and guess the cancer type and growth pattern. The goal is to see if visual clues can help choose…

This study looks at whether a detailed ultrasound system (IOTA) can better predict which ovarian cysts in unborn babies will cause problems. About 100 pregnant women will join, and their babies' cysts will be tracked with multiple scans before and after birth. The goal is to safe…

This study surveys 480 Italian dental students to understand their attitudes, knowledge, and any discriminatory behavior toward HIV-positive patients. Researchers want to see if students feel uncomfortable treating these patients and if they follow proper sterilization protocols.…

This study tests whether using ultrasound during surgery helps doctors better remove deep endometriosis from the bowel while keeping the bowel wall safe. About 57 women aged 20-60 with bowel endometriosis will take part. The goal is to see if ultrasound measurements during surger…

This study will follow 100 adults in southern Italy who have severe infections caused by carbapenem-resistant Enterobacterales (CRE), a type of bacteria that is hard to treat. Researchers want to learn more about the bacteria's resistance patterns and genetic traits to help docto…

This study aims to better understand why some young people (ages 18-25) with mood disorders are at risk for suicide. Researchers will combine brain imaging, genetic tests, and microbiome analysis to identify risk factors. They will also test whether a non-invasive brain stimulati…

This study looks at a rare condition called MRKH syndrome, where women are born without a fully formed uterus and vagina. Researchers will use ultrasound and genetic tests to better describe the different ways this condition can appear. The goal is to create a new, more detailed …