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Scientists hunt for hidden triggers of dangerous blood clots

NCT ID NCT07242521

Knowledge-focused Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to discover new reasons why blood clots form in people with heart disease, diabetes, and other illnesses. Researchers will analyze blood samples from 200 patients with narrowed neck arteries to look for markers of cell damage and clotting factors. The goal is to find better ways to prevent or treat clotting problems in the future.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2025

An estimate. Start dates often move.

Expected to finish

Feb 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with carotid artery stenosis (CAS); asymptomatic form of CAS (Cohort A) and symptomatic CAS (Cohort B). In each cohort, T2DM and not diabetic patients will be enrolled with a 1:1 ratio.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria:Patients with carotid artery stenosis (CAS). One hundred patients with atheromatous carotid artery stenosis (CAS), admitted to the Unit of Vascular Surgery (RU-UniCATT) of Fondazione Policlinico Universitario A. Gemelli IRCCS for carotid endoarterectomy or stenting as per standard of care, will be enrolled. These patients will be divided into two cohorts composed of 50 patients each: 1) asymptomatic form of CAS (Cohort A) and 2) symptomatic CAS (Cohort B). In each cohort, T2DM and not diabetic patients will be enrolled with a 1:1 ratio. Patients on low-dose aspirin, statins, ACE inhibitors, metformin, pioglitazone, and sulfonylureas for DM patients. Exclusion Criteria:any hemorrhagic coagulopathy, familial hypercholesterolemia, liver cirrhosis, sepsis, recent (12 months) surgery, trauma, IMA, or ischemic stroke, age \<18 years old and inability to understand and sign the informed consent form.

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Conditions

The condition(s) this trial relates to.

carotid stenosis hereditary von Willebrand disease von Willebrand disease (hereditary or acquired)

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carotid artery stenosis asymptomatic Carotid artery stenosis symptomatic Oxidative stress Vonwillebrand disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.