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Could a daily cocoa drink help keep blood vessels young?

NCT ID NCT07747714

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This trial tests whether taking a daily cocoa flavanol supplement for 4 to 8 weeks can improve blood vessel function and reduce inflammation in healthy men aged 30 to 75. Half the participants will receive the flavanol supplement, while the other half gets a low-flavanol control powder. Researchers will measure changes in blood markers related to inflammation, oxidative stress, and vascular health to see if the flavanols make a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cocoa flavanol supplement
What this could lead to
If daily cocoa flavanols improve markers of blood vessel health and reduce inflammation, this could support their use as a simple dietary supplement to support cardiovascular wellness in healthy adults.
What could go wrong
This is a small, short-term study in generally healthy men, so any benefits may not apply to women, people with health conditions, or long-term outcomes. The supplement may also have no measurable effect on the markers being tested.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 75 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male participants aged 30 to 75 years. * Able and willing to provide written informed consent. * Generally healthy, as determined by medical history and screening assessments. * Willing and able to comply with all study procedures, including blood collection, daily study-product intake, and required study visits. * Willing to consume the assigned cocoa flavanol supplement or low-flavanol control product once daily for the duration of the study. * Willing to provide peripheral blood samples at baseline and at the end of the intervention. * Willing to maintain generally stable dietary, exercise, sleep, medication, and supplement habits during the study. * Willing to refrain from initiating new supplements, restrictive diets, fasting regimens, or major exercise programs during the study. * Not currently taking medications or supplements known to substantially affect vascular function, nitric oxide pathways, inflammation, oxidative stress, or coagulation, unless approved by the investigator. Exclusion Criteria: * Female biological sex. * Younger than 30 years or older than 75 years. * Known cardiovascular, metabolic, renal, hepatic, inflammatory, or autoimmune disease, including coronary artery disease, diabetes mellitus, chronic kidney disease, chronic liver disease, rheumatoid arthritis, or another clinically significant inflammatory disorder. * Hypertension requiring prescription medication. * Active infection, acute illness, or other clinically significant medical condition at screening or baseline. * Current use of medications or supplements that may substantially affect vascular function, inflammatory biomarkers, nitric oxide pathways, oxidative stress, or coagulation, including chronic nonsteroidal anti-inflammatory drugs, systemic corticosteroids, anticoagulants, antiplatelet drugs, prescription immunomodulatory agents, phosphodiesterase-5 inhibitors, or high-dose antioxidant supplements, unless approved by the investigator. * Known allergy, hypersensitivity, or intolerance to cocoa, chocolate, cocoa flavanols, or any ingredient in either study product. * Gastrointestinal disease or condition that may interfere with digestion or absorption of the study product, including celiac disease, inflammatory bowel disease, active gastritis, or a clinically significant malabsorption disorder. * Current smoking or vaping of nicotine or cannabis products. * Major psychiatric illness, cognitive impairment, or another condition that may interfere with informed consent, adherence, or completion of study procedures. * Alcohol or drug abuse within the previous 12 months that, in the investigator's judgment, may affect participant safety or study adherence. * Participation in another interventional clinical study within 30 days before screening. * Plans to begin a new medication, supplement, restrictive diet, fasting regimen, or major exercise program during the study period. * Any condition or circumstance that, in the investigator's judgment, would increase participant risk, interfere with study procedures, compromise adherence, or affect interpretation of the study results.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Black Forest Supplements (The Black Forest LLC)

    Miami, Florida, 33166, United States

  • Power Wellness Spot

    Miami, Florida, 33166, United States

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