Hidden brain disease study aims to prevent stroke and dementia
NCT ID NCT06878430
First seen Jun 27, 2026 · Last updated Sep 10, 2026 · Updated 2 times
Summary
This study looks at people aged 65 and older who have signs of brain blood vessel disease on a past scan but no history of stroke, dementia, or other major brain conditions. Researchers will collect information on daily function, thinking skills, speech, and any new vascular events over time. The goal is to find the best ways to follow these individuals, which will help design future trials that could test treatments to reduce the risk of stroke or dementia.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could pave the way for larger trials that test treatments to lower the risk of stroke or dementia in people with hidden brain blood vessel disease.
- What could go wrong
- This is a very early pilot study with only 100 participants, so it won't directly test any treatment. It focuses on measuring outcomes and feasibility, not on proving a therapy works.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Oct 2026
An estimate. Start dates often move.
- Expected to finish
-
Jun 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
People aged 65 years or older living in Scotland, UK
- Ages
-
65 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * People who, at the time the letter is prepared or are identified by a clinician * Age ≥ 65 years * Have no known history of: * Stroke or TIA * Dementia * Parkinson's disease * Multiple sclerosis * Metastatic cancer (or non-meningioma brain tumour). * A CT or MRI scan report ≤5 years before study start date with of one or more of: * Cerebral small vessel disease * Deep old ischaemic stroke * Cortical old ischaemic stroke Exclusion Criteria: * Text of brain scan report unreadable * Do not consent to take part in study procedures * Unable to consent * Unable to communicate by email, letter or telephone through language, speech disability or lack of address * Unlikely to survive one year past enrolment in judgement of the study investigator
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Covert cerebrovascular disease are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.