University Of Edinburgh

This study tests several drugs to see if they can slow down motor neuron disease (MND) and help people live longer. About 1,150 adults with MND will be randomly assigned to receive one of the study drugs or a placebo. The trial uses an adaptive design, meaning ineffective drugs c…

This study tests whether two medications, dapagliflozin and bosentan, can improve blood vessel function in people with large vessel vasculitis (LVV), a condition that damages arteries and raises the risk of heart attacks and strokes. About 60 adults with stable LVV will take both…

This study tests a new way for people with gout to manage their condition. Participants will either use a smartphone app to check their own urate levels and adjust medication, or receive standard care. The goal is to see if this self-monitoring approach reduces painful gout flare…

This study is testing whether a smartphone app can help diagnose and monitor brain diseases like dementia, Parkinson's, multiple sclerosis, and motor neuron disease by recording and analyzing speech. Researchers will compare speech patterns from 150 people with these conditions t…

This study tests a new imaging test (PET-CT scan) that can see blood clots in the heart arteries from outside the body. The goal is to better identify what caused a heart attack, so patients get the right treatment. Researchers will recruit 80 adults who recently had a heart atta…

This study tests a robot-controlled camera pill that people swallow to look for causes of iron deficiency anaemia in the stomach and small bowel. It aims to replace the standard upper endoscopy (a tube with a camera) with a less invasive pill. The study involves 100 adults who ha…

This study tests a new bedside blood test that can diagnose methanol poisoning in minutes using just a drop of blood. Methanol poisoning is hard to spot because its symptoms look like other illnesses, and standard lab tests take hours. The trial will check how accurate and useful…

This study tests if brief whole-body exposure to extreme cold (around -120°C) can safely reduce pain and improve quality of life for people with endometriosis. Up to 30 participants will attend five 3-minute cryotherapy sessions over four weeks. Researchers will measure pain chan…

This study tests whether a virtual group fatigue management program helps people with lupus feel less tired. 90 participants will either get a fatigue booklet alone or the booklet plus a 4- or 7-week online group program. The goal is to find a practical, cost-effective way to add…

This study will closely examine the physical and mental health of 100 adults admitted to NHS psychiatric wards. Researchers want to learn how common physical illnesses are in this group and how severe their mental health symptoms are. The goal is to better understand the overall …

This study watches how aortic stenosis (a heart valve disease) develops and changes over time, even after valve replacement. About 300 people over age 50 with mild to severe disease will get heart scans every 6 months to track calcium buildup, scarring, and inflammation. The goal…

This study talks to children with cerebral palsy who have sleep breathing problems, their parents, and their doctors. The goal is to learn about their experiences with diagnosis and treatment, like using a breathing mask at night. By understanding what helps and what gets in the …

This study uses two separate questionnaires to learn about the experiences of people with Takayasu arteritis (TAK) and how doctors manage the condition. About 50 patients and an unspecified number of physicians will share their views on symptoms, treatment priorities, and unmet n…

This study aims to better understand broken heart syndrome (takotsubo cardiomyopathy) by using a special dye called manganese during heart MRI scans. Researchers will also see how different heart medications affect the heart's uptake of this dye. The study will involve 100 adults…

This study aims to collect detailed information from 1000 people in the UK with endometriosis to help doctors diagnose and treat the condition more effectively. Participants will use a mobile app to track symptoms, provide biological samples, and wear a smartwatch to monitor slee…

This study looks at whether healthcare data and information collected remotely (like from an app) can accurately predict asthma attacks in children and young people aged 5 to 17. Researchers will monitor routine health records for all kids with asthma in the area, and a smaller g…

This study collects and freezes testicular tissue from prepubertal boys who are about to receive cancer treatment that has a high risk of causing infertility. The tissue is stored for possible future use to help them have children, and a portion is used for research to better und…

This study aims to collect video recordings and hand-movement data from 300 patients and up to 20 doctors during routine bronchoscopy procedures. The goal is to use this data to understand how skilled doctors perform the procedure and eventually create training tools for new medi…

This study looks at whether a blood test can help doctors track how well throat cancer treatment is working and catch any return of the cancer early. Researchers will collect blood samples from 250 people with throat cancer in Scotland and analyze them for cancer DNA. The goal is…

This study aims to find early signs of scarring (fibrosis) in the heart muscle of people with aortic stenosis, heart damage from chemotherapy, or carcinoid syndrome. Researchers will use special PET scans to see active scarring. The goal is to better understand and detect these c…

This study looks at how common sleep breathing problems are in children with cerebral palsy (CP) across the UK, and how many use breathing machines at night. Researchers will track new cases over a year and explore what helps or hinders access to treatment. The goal is to improve…

This study explores whether a wrist-worn activity monitor can help doctors understand how people recover after leaving the intensive care unit (ICU). Forty adults who spent more than a week in the ICU will wear the device at home and answer health questionnaires. The goal is to s…

This study is looking at whether a simple, noninvasive eye scan can detect signs of inflammation in women with endometriosis. Researchers will compare eye images from 100 women with and without the condition. The goal is to learn more about how endometriosis affects the body, not…

This study is testing whether a special heart scan (CTCA) can better identify kidney transplant candidates at highest risk for heart attacks or heart-related death. Current methods often miss those most at risk. The study will follow 332 adults on the transplant waiting list to s…

This study looks at whether wearable sensors (like a smart patch) can catch early signs of a patient getting worse after surgery. About 1,332 adults having major surgery will wear sensors on their chest and fingers for up to 10 days. The data will be used to design better early-w…

This study looks at whether giving patients who come to the emergency room with chest pain their heart test results can help them understand their risk of future heart problems. Researchers will have a short conversation with 118 adults in Scotland about their heart health and se…

This study aims to find a better way to detect scarring in the intestines of people with Crohn's disease. Researchers will use a special dye and PET/CT scans to see if they can identify early scarring and track how it worsens over time. The goal is to help develop new treatments …

This study looks at what 'visual frailty' means for people aged 60 and older who have age-related macular degeneration (AMD). Researchers will measure vision, reading ability, daily function, mental health, and other health conditions to create a new assessment tool. The goal is …

This study looks at muscle wasting, weight loss, and tiredness in people with stomach, pancreas, or bowel cancer who are having surgery. Researchers will track changes in body composition, physical activity, and quality of life over a year. The goal is to better understand cachex…

This study explores whether a special type of MRI, called manganese-enhanced MRI (MEMRI), can help detect early signs of heart and kidney problems in people with various kidney diseases, including acute kidney injury, chronic kidney disease, and kidney transplant. Researchers wil…

This study looks at why vein grafts used in heart bypass surgery can narrow or fail over time. Researchers will use special full-body PET scans to see what is happening inside the grafts and how this affects the heart and body. The study involves 70 adults who recently had bypass…

This study looks at whether a rapid point-of-care test for the pregnancy hormone HCG can confirm that a very early medical abortion (before 6 weeks) has worked sooner than the usual 7-day wait. About 130 participants will have their HCG levels checked on day 0 and again between d…

This study looks at how blood pressure and artery stiffness change between day and night in 120 people at increased risk for heart disease, including those with kidney issues. Researchers want to understand who lacks the healthy nighttime blood pressure drop and whether taking me…

This study looks at how to better prevent cervical cancer in women who have experienced homelessness, substance use, transactional sex, or incarceration. Researchers will offer HPV vaccination and testing during regular sexual health clinic visits to see if this approach works an…

This study aims to understand how inflammation, calcium buildup, and blood clots behave in the arteries of people with peripheral artery disease (PAD). Researchers will use special PET scans to take detailed pictures of these processes in the legs and other parts of the body. Abo…

This study is testing whether a special full-body PET scan can more accurately detect active disease and long-term heart risk in people with ANCA vasculitis, a rare autoimmune condition that inflames blood vessels. Researchers will scan up to 90 patients with active disease and 3…

This observational study looks at whether leaky blood vessels in the eye can signal similar damage in the brain, which is linked to strokes and dementia. Researchers will inject a fluorescent dye into 40 participants and take detailed eye images. The goal is to see if eye vessel …

This study looks at how losing weight can reverse type 2 diabetes by reducing fat in the pancreas. Researchers will follow 104 people, including those without diabetes, with prediabetes, and with short- or long-term diabetes. Participants will follow a very low-calorie diet for 8…

This study follows 200 kidney transplant patients in Scotland to see if certain biomarkers can help predict transplant rejection. Researchers will collect urine samples and track health outcomes during routine follow-up visits. The goal is to improve how doctors monitor and manag…

This study aims to better understand the role of blood clots in different types of stroke. Researchers will use a special PET scan tracer that sticks to activated platelets, the cells that form clots, to see where clots are in the body. The study will involve 120 adults who have …