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New scan technique aims to solve mystery of failing heart bypass grafts

NCT ID NCT06800430

Knowledge-focused Sponsor: University of Edinburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study uses advanced total-body PET scans to look inside vein grafts after coronary artery bypass surgery. Researchers want to understand why some grafts fail, leading to heart attacks or strokes. They will scan 70 patients—some soon after surgery and others years later—to track changes in the grafts and the rest of the body. The goal is to find clues that could help prevent graft failure in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
radioactive tracers ([18F]-GP1, [68Ga]-DOTATATE, [68Ga]-FAPI) for PET imaging
What this could lead to
If successful, this study could reveal why vein grafts fail after bypass surgery, pointing toward new ways to prevent graft failure and improve patient outcomes.
What could go wrong
This is an early observational study with only 70 participants, so findings may not apply to all patients. It aims to understand the problem, not test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

We will recruit two populations of patients following CABG surgery. Participants will be prospectively recruited following CABG surgery (cohort 1), or identification of clinically suspected saphenous vein graft failure (cohort 2). Recruitment will for both cohorts will be from a single, tertiary centre (Royal Infirmary of Edinburgh).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

INCLUSION CRITERIA: Cohort 1: Patients undergoing CABG surgery * Males and females over 18 years of age * Patients undergoing CABG surgery for multivessel coronary artery disease, who receive at least one saphenous vein graft Cohort 2: Patients with symptomatic saphenous vein graft vasculopathy * Males and females over 18 years of age * Patients who underwent CABG surgery ≥ 5 years prior to recruitment for multivessel disease and received 2 or more saphenous vein grafts * Referred for invasive coronary angiography due to recurrent symptoms and with a high suspicion of graft vasculopathy EXCLUSION CRITERIA: * Patients with a life expectancy of \< 2 years * Renal failure (estimated glomerular filtration rate \<30 mL/min/1.73 m2) * Patients on immunosuppressive therapies * Females of child-bearing age who are pregnant or breastfeeding, * Known allergy or contraindications to iodinated contrast or radiotracer * Patients who are unable to tolerate the supine position * Patients who are unable to provide informed consent

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder coronary artery disorder heart disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery bypass Coronary artery bypass graft Coronary artery bypass graft surgery (CABG) Graft failure

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Royal Infirmary of Edinburgh

    RECRUITING

    Edinburgh, Midlothian, EH16 4SA, United Kingdom

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