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Blood test could revolutionize throat cancer monitoring

NCT ID NCT05539638

Knowledge-focused Sponsor: University of Edinburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing a blood test that looks for tiny pieces of cancer DNA in the bloodstream of people with throat cancer. The goal is to see if this test can track how well treatment is working and spot if the cancer comes back earlier than current methods. Researchers will collect blood samples from 250 participants over time and compare the results with standard scans and biopsies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2022

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Number of participants/volunteers = 400 patients with oropharyngeal squamous cell carcinoma recruited over 3-4 sites then followed for a median of 3 years.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with oropharyngeal squamous cell carcinoma * Both HPV positive and negative disease Exclusion Criteria: * Patients under 18 years of age * Those who lack capacity to consent * Patients with non-squamous cell carcinoma * Patients with squamous cell carcinoma out with the oropharynx

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Conditions

The condition(s) this trial relates to.

human papilloma virus infection oropharynx squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Human papillomavirus (HPV) Oropharyngeal squamous cell carcinoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    5 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Glasgow Royal Infirmary

    RECRUITING

    Glasgow, United Kingdom

  • Monklands Hospital ENT

    RECRUITING

    Airdrie, United Kingdom

  • Ninewells Hospital

    NOT_YET_RECRUITING

    Dundee, DD2 1SG, DD2 1SG, United Kingdom

  • Summerfield House - NHS Grampian

    NOT_YET_RECRUITING

    Aberdeen, AB15 6RE, United Kingdom

  • The Royal Infirmiry

    NOT_YET_RECRUITING

    Edinburgh, United Kingdom

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