OROPHARYNGEAL SQUAMOUS CELL CARCINOMA

This study tests whether giving two immunotherapy drugs (cemiplimab and CDX-1140) before surgery works better than one drug alone for people with stage III-IV head and neck cancer. About 44 participants will receive either the combo or just cemiplimab before their tumor is remove…

This study is for people with a favorable type of throat cancer caused by HPV. Researchers want to see if giving less intense radiation and chemotherapy, based on the patient's HPV type and virus levels in the blood, can control the cancer just as well as standard stronger treatm…

This study is testing whether a lower dose of radiation (30 Gy) can safely treat HPV-positive oropharyngeal cancer while reducing side effects. About 31 adults with this type of throat cancer will receive the reduced radiation along with standard chemotherapy. The main goal is to…

This study tests an experimental drug called CUE-101 in 30 people with a specific type of throat cancer caused by HPV16. The drug is given before standard treatments like surgery or chemoradiation to see if it safely boosts the body's immune response against the cancer. Researche…

This phase 3 trial tests whether using a sentinel lymph node biopsy can help doctors decide which side of the neck needs radiation, instead of treating both sides in all patients. About 242 adults with certain head and neck cancers will be randomly assigned to standard bilateral …

This study tests whether a blood test that measures HPV levels can help doctors safely give lower doses of radiation to people with HPV-related throat cancer. About 45 participants will receive either lower-dose radiation plus chemotherapy or the standard dose. The goal is to see…

This study aims to see if a shorter, lower-dose radiation treatment after robotic surgery can improve quality of life for people with HPV-related throat cancer. About 42 adults with intermediate-risk disease will receive a reduced radiation schedule. The main goal is to see if pa…

This study tests whether a special CT scan (dual-energy CT) works as well as MRI for staging mouth and throat cancers. If it does, patients may need one less scan, speeding up treatment and freeing up MRI machines. The study will enroll 30 adults with these cancers and compare th…

This study tests if adding BMX-001 to standard care can reduce severe mouth sores caused by chemoradiation in head and neck cancer patients. About 98 adults will receive either BMX-001 or a placebo alongside their usual treatment. The goal is to see if BMX-001 helps prevent painf…

This study tests whether giving radiation only to high-risk areas after head and neck cancer surgery can reduce side effects without raising the chance of cancer coming back. About 50 adults with certain head and neck cancers will receive a personalized radiation plan. The goal i…

This study looks at whether a blood test can help doctors track how well throat cancer treatment is working and catch any return of the cancer early. Researchers will collect blood samples from 250 people with throat cancer in Scotland and analyze them for cancer DNA. The goal is…

This study aims to find biological markers (biomarkers) that show up in the blood, tissue, or saliva when a person has HPV-related throat cancer, and disappear after successful treatment. Researchers will collect samples from 560 adults with or without the cancer to compare. The …

This study is for people with head and neck cancers who are getting radiation therapy. It uses special PET/CT scans to see how radiation affects the blood vessels in the neck. The goal is to learn if a newer scan method (F-18 NaF PET/CT) can detect these changes better than the s…

This study aims to identify genetic changes in oropharyngeal cancer (a type of throat cancer) in Taiwanese patients. Researchers will use advanced DNA sequencing on tumor samples from 300 participants to find new biomarkers and help design future clinical trials. The study does n…

This study follows 220 people with HPV-related throat cancer after treatment to see if two things can predict if the cancer returns: changes in certain genes (TRAF3 and CYLD) and levels of HPV DNA in the blood. Participants will give blood samples and have regular CT scans. The g…

This study looks at whether offering hearing tests close to home or online can help more head and neck cancer patients get their hearing checked during treatment. Chemotherapy and radiation can cause hearing loss, but many patients skip follow-up tests. The goal is to see if easi…