University Of Edinburgh

This study planned to give children with mild-to-moderate ulcerative colitis either MitoQ (an antioxidant supplement) or a placebo for 24 weeks, alongside their usual treatment. The goal was to see if MitoQ could improve symptoms, reduce inflammation, and lower the need for stero…

This study tests whether MitoQ, a mitochondrial antioxidant, can help people with moderate ulcerative colitis (UC) during a flare-up. About 79 adults with active UC will take either MitoQ or a placebo daily for 24 weeks, alongside standard steroid treatment. The goal is to see if…

This study looks at people with severe aortic stenosis (a narrowed heart valve) who don't yet have symptoms. Researchers use MRI scans to find early heart muscle scarring, which can signal future trouble. Participants with scarring are randomly assigned to either standard care or…

This study aimed to compare a new, less painful method for diagnosing serious eye infections (microbial keratitis) with the current standard practice. The new method uses a soft membrane to collect germs from the eye surface, instead of a blade. The study was withdrawn before enr…

This study tests a computer tool called CoDE-HF that helps doctors quickly diagnose acute heart failure—a sudden inability of the heart to pump blood. The tool combines a blood test (NT-proBNP) with patient information to give a probability of heart failure. Researchers will stud…

This study compares two ways to prevent heart attacks in people at risk for heart disease. One group gets a CT scan of their heart arteries to guide treatment, while the other group follows standard care based on a risk score. About 6,100 adults aged 40-70 with risk factors like …

This study follows people who carry a gene mutation that puts them at high risk for Paget's disease of the bone. Researchers want to see if a single dose of zoledronic acid (a bone-strengthening drug) can prevent or delay the disease compared to a placebo. Participants will be mo…

This study looks at whether giving blood transfusions to anemic patients after they leave the intensive care unit (ICU) can help them feel less tired and recover better. About 346 adults who are ready to leave the ICU and have low hemoglobin will be randomly assigned to either st…

This study follows 124 golfers who had hip, knee, or shoulder replacement surgery to see how many return to golf and how long it takes. Researchers will also track changes in handicap, mobility, and joint pain over one year. The goal is to give patients and doctors realistic expe…

This study monitors oxygen levels in the brains of two groups of newborns at high risk of brain injury: full-term babies undergoing cooling treatment for oxygen deprivation, and extremely premature babies. Using a safe, non-invasive light sensor (NIRS), researchers aim to see if …

This study looks at people who go to the hospital with chest pain but are told they did not have a heart attack. Even so, some may have hidden heart disease that raises their risk of a future heart attack. Researchers want to see if a special heart scan (CTCA) can find this hidde…

This study looked at whether certain genes that make people more prone to bleeding can cause a stool test for colon cancer to show a false-positive result. Researchers planned to collect saliva samples from people who had a raised stool blood test but a normal colonoscopy, and co…

This study aims to classify patients with atrial fibrillation based on the electrical patterns in their hearts using computer simulations, rather than just how long they've had the condition. Researchers will study 91 people already scheduled for a heart procedure to see if this …

This study surveys general dentists in two UK regions to understand why silver diamine fluoride (SDF) — a quick, needle-free liquid that stops tooth decay — isn't widely used for children. Around 34 dentists will answer questions about their knowledge, attitudes, and barriers to …

This study tests whether people with possible angina can get a full risk assessment within one working day using a digital health questionnaire, a personal ECG, and a finger-prick blood test. Researchers will enroll 500 adults referred to a chest pain clinic. The goal is to see i…

This study compares two ways to train doctors in laparoscopic (keyhole) surgery: an AI-enhanced game-based simulator versus a standard box trainer. About 157 medical students and doctors with little or some experience will be randomly assigned to one method. The goal is to see if…

This study looks at whether a genetic test can predict who will develop Paget's disease of the bone, a condition that can cause pain, deformity, and hearing loss. Researchers will enroll 135 people aged 45 and older who have a parent or sibling with Paget's but do not have the di…

This study looks at whether a future large trial on treatments for brain hemorrhage (bleeding in the brain) is acceptable to patients, their families, and doctors. It involves 169 adults who had a stroke from a brain bleed. Participants watch a video, read information, give conse…

This study looks at how family doctors in Latin America provide palliative care—care that helps people with serious illnesses feel better and live as well as possible. Researchers will work with 30 to 50 healthcare professionals to understand what helps or hinders this care. The …

This study follows 440 people in Scotland who were recently diagnosed with relapsing-remitting multiple sclerosis (MS). Researchers will track their health for 5 to 10 years using brain scans and other tests to see how the disease progresses. The goal is to better predict what ea…

This study follows 400 people already enrolled in the larger SCOT-HEART 2 trial to see how being in the trial influences their diet, exercise, smoking, and weight. Researchers will measure these habits at the start and again after 6 months. For those who get a CT scan of their he…

This study tests a new finger-prick device that measures troponin, a heart damage protein, in about 10 minutes—much faster than the usual 2-hour lab test. Researchers will enroll 1000 adults with chest pain in the emergency department to see if this quick test helps diagnose hear…