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Heart scan could spot hidden risk in chest pain patients

NCT ID NCT03952351

Knowledge-focused Sponsor: University of Edinburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a special heart scan (CTCA) can help find hidden heart disease in people who come to the hospital with chest pain but are not having a heart attack. About 3,170 adults with slightly elevated troponin levels (a sign of heart stress) will get the scan to see if it helps prevent future heart attacks or heart-related deaths. The goal is to improve how doctors identify and treat those at risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

3,170 people

The number who actually took part.

Started

Jan 2026

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Presenting to hospital with symptoms of suspected acute coronary syndrome * Age 18 years and over * Maximum high-sensitivity cardiac troponin concentration between 5ng/L and the 99th percentile Exclusion Criteria: * Diagnosis of myocardial infarction during index presentation * Clear alternative diagnosis or participant requires further inpatient clinical assessment * Recent CTCA or invasive coronary angiogram (within 1 year) * Patient inability to undergo CT scanning, e.g. due to severe renal failure (estimated glomerular filtration rate \<30 mL/min) or major allergy to iodinated contrast media * Current pregnancy or breast feeding * Inability to give informed consent * Further investigation for coronary artery disease would not be in the patient's interest, e.g. due to limited life expectancy, quality of life or functional status * Previous randomisation into the trial

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery disease

Contacts and locations

Locations

  • Lewisham & Greenwich NHS Trust

    London, United Kingdom

  • Milton Keynes University NHS Hospital

    Milton Keynes, United Kingdom

  • NHS Greater Glasgow and Clyde

    Glasgow, United Kingdom

  • NHS Lothian

    Edinburgh, United Kingdom

  • North Tees NHS Hospital Foundation

    Stockton, United Kingdom

  • Royal Berkshire NHS Foundation Trust

    Reading, United Kingdom

  • Torbay & South Devon NHS Foundation Trust

    Torquay, United Kingdom

  • University Hospital Southampton NHS Trust

    Southampton, United Kingdom

  • University Hospitals Plymouth NHS Trust

    Plymouth, United Kingdom

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