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Could a lifestyle makeover keep your brain sharp?

NCT ID NCT05007353

Prevention Sponsor: National University of Singapore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial tests whether a structured lifestyle program—combining exercise, healthy eating, cognitive training, and social activities—can slow cognitive decline in older adults at risk of dementia. Participants aged 60-80 with modifiable risk factors will be randomly assigned to either the intensive program or a self-guided education group. The study aims to see if these lifestyle changes can protect memory and thinking over two years.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Structured Lifestyle Intervention (SLI) - a program combining physical exercise, healthy diet, cognitive training, social stimulation, and vascular risk management
What this could lead to
If successful, this could provide a practical, non-drug approach to delay cognitive decline and dementia in at-risk older adults.
What could go wrong
The trial is large but results depend on long-term adherence; lifestyle changes may be hard to sustain, and benefits might not be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,212 people

The number who actually took part.

Started

Aug 2021

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 60-80 years * Able to understand English/Chinese * Risk of dementia: Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) dementia risk score ≥6 indicating the presence of modifiable risk factors Modifiable lifestyle factors (fulfilling at least one of the following LIBRA index for diet, cognitive activity, physical activity) * Cognitive performance at the mean level or slightly lower than expected for age (MoCA ≥18, ≤27) * No plans to travel outside of Singapore for an extended period of time over the course of the study * Free of physical disabilities that preclude participation in the study * Willing to complete all study-related activities for 24 months * Willing to be randomized to either lifestyle intervention group Exclusion Criteria: * malignant diseases * dementia * major depression * symptomatic cardiovascular disease * revascularisation within 1 year * severe loss of vision, hearing or communicative ability * other conditions inhibiting from safe engagement in the prescribed intervention and other conditions preventing cooperation, as judged by the study physician

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Conditions

The condition(s) this trial relates to.

Alzheimer disease brain disorder central nervous system disorder Cognition Disorders cognitive disorder Cognitive Dysfunction mental disorder nervous system disorder psychiatric disorder vascular dementia dementia prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer disease Brain diseases Central nervous system diseases Cognition disorder Cognitive impairment Dementia Mental disorders Nervous system diseases Neurocognitive disorders Vascular cognitive impairment

Contacts and locations

Locations

  • National Neuroscience Institute @ Tan Tock Seng Campus (NNI @ TTSH campus)

    Singapore, Singapore, 308433, Singapore

  • National University Hospital

    Singapore, Singapore, 117600, Singapore

  • National University of Singapore, Yong Loo Lin School of Medicine

    Singapore, Singapore, 117600, Singapore

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