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Can a daily migraine pill stop attacks fast? new trial aims to find out

NCT ID NCT06241313

Symptom relief Sponsor: AbbVie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 11, 2026 · Updated 2 times

Summary

This study tests whether atogepant, a drug already used to prevent migraines, can also treat migraine attacks quickly. About 1300 adults with a history of migraines will take either atogepant or a placebo when they have a migraine, and then report pain levels and symptoms after 2 hours. The goal is to see if the drug provides fast relief from headache and associated symptoms like nausea or light sensitivity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
atogepant (also known as Qulipta or Aquipta)
What this could lead to
If successful, this could provide a new, fast-acting option to stop migraine attacks in their tracks, offering relief within hours.
What could go wrong
This is a Phase 3 trial, but results are not yet known. Atogepant is already approved for migraine prevention, not acute treatment, so its effectiveness for acute attacks is still unproven. Side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

2,158 people

The number who actually took part.

Started

Mar 2024

Finished

Aug 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * History of migraine (with or without aura) according to the International Classification of Headache Disorders 3rd Edition (ICHD-3) for \>= 12 months prior to Visit 1/Screening. * History of 2 to 8 migraine attacks of moderate to severe headache pain in each of the 3 months prior to Visit 1/Screening per investigator judgment. * Migraine onset before the age of 50. * History of migraines lasting between 4 and 72 hours when untreated or treated unsuccessfully and migraine episodes separated by at least 48 hours of headache pain freedom. Exclusion Criteria: * History of an average of 15 or more headache days per month in the 6 months prior to Visit 1/Screening per the investigator's judgment, or a current diagnosis of chronic migraine as defined by ICHD-3. * Require hospital/emergency room treatment for migraine attacks on 3 or more occasions within 6 months prior to Visit 1/Screening.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Migraine

Contacts and locations

Locations

  • A.O.U. CITTA' DELLA SALUTE E DELLA SCIENZA DI TORINO - Ospedale Molinette /ID# 258591

    Turin, Piedmont, 10126, Italy

  • ASL 1 Abruzzo - Ospedale SS. Filippo and Nicola /ID# 258590

    Avezzano, L Aquila, 67051, Italy

  • ASST degli Spedali Civili di Brescia /ID# 258594

    Brescia, 25123, Italy

  • AZ Groeninge /ID# 257586

    Kortrijk, 8500, Belgium

  • Algemeen Ziekenhuis Sint-Jan Brugge /ID# 257585

    Bruges, West-Vlaanderen, 8000, Belgium

  • Ambenet Hausarztpraxis /ID# 258075

    Leipzig, Saxony, 04107, Germany

  • Ashgate Medical Practice /ID# 258923

    Chesterfield, Derbyshire, S40 4AA, United Kingdom

  • Athleticomed Sp. z o.o /ID# 258253

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-752, Poland

  • Axon Clinical, s.r.o. /ID# 259024

    Prague, 140 00, Czechia

  • Baotou Central Hospital /ID# 258786

    Baotou, 014040, China

  • Beijing Friendship Hospital /ID# 258830

    Beijing, Beijing Municipality, 100032, China

  • CCR Ostrava, s.r.o. /ID# 257743

    Ostrava, Ostrava-mesto, 702 00, Czechia

  • CHR de la Citadelle /ID# 257587

    Liège, 4000, Belgium

  • CTC EbbePark Linkoping /ID# 261170

    Linköping, 582 13, Sweden

  • Cabinet Prive Dr Sava /ID# 257581

    Saint-Nicolas, Liege, 4420, Belgium

  • Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 258076

    Berlin, 10117, Germany

  • China Medical University Hospital /ID# 258417

    Taichung, 40447, Taiwan

  • Chinese PLA General Hospital /ID# 257540

    Beijing, Beijing Municipality, 100853, China

  • Chonnam National University Hospital /ID# 259154

    Gwangju, Gwangju Gwang Yeogsi, 61469, South Korea

  • Clinica Universidad de Navarra - Pamplona /ID# 257656

    Pamplona, Navarre, 31008, Spain

  • Clinical Research Center Medic-R /ID# 258268

    Poznan, Greater Poland Voivodeship, 60-848, Poland

  • Clintrial s.r.o. /ID# 257663

    Prague, 100 00, Czechia

  • Cortex Study Center /ID# 259032

    Budapest, 1026, Hungary

  • DADO MEDICAL s.r.o. /ID# 257672

    Prague, 120 00, Czechia

  • DOI Internal Medicine-Neurology Clinic /ID# 259009

    Hiroshima, 730-0031, Japan

  • FORBELI s.r.o. /ID# 259019

    Prague, 160 00, Czechia

  • Fakultni Nemocnice Ostrava /ID# 259023

    Ostrava, Ostrava-mesto, 708 52, Czechia

  • Fakultni Thomayerova nemocnice /ID# 259021

    Prague, 140 59, Czechia

  • Fondazione Mondino Istituto Neurologico Nazionale a Carattere Scientifico IRCCS /ID# 258589

    Pavia, 27100, Italy

  • Fondazione Policlinico Universitario Campus Bio-Medico /ID# 258588

    Roma, 00128, Italy

  • Fujian Medical University Union Hospital /ID# 259575

    Fuzhou, Fujian, 350001, China

  • General Hospital of Northern Theater Command /ID# 259556

    Shenyang, Liaoning, 110016, China

  • Guangzhou First People's Hospital /ID# 258656

    Guangzhou, Guangdong, 510180, China

  • H.-Hartziekenhuis Lier /ID# 257577

    Lier, 2500, Belgium

  • Hainan General Hospital /ID# 259548

    Haikou, Hainan, 570311, China

  • Hallym University Dongtan Sacred Heart Hospital /ID# 257999

    Hwaseong, Gyeonggido, 18450, South Korea

  • Hebei General Hospital /ID# 258583

    Shijiazhuang, Hebei, 500051, China

  • Higashi Sapporo Neurology And Neurosurgery Clinic /ID# 262708

    Sapporo, Hokkaido, 003-0003, Japan

  • Hospital Clinico Universitario Lozano Blesa /ID# 257661

    Zaragoza, 50009, Spain

  • Hospital Clinico Universitario de Valladolid /ID# 257653

    Valladolid, 47003, Spain

  • Hospital Universitario La Paz /ID# 257654

    Madrid, 28046, Spain

  • Hospital Universitario Marques de Valdecilla /ID# 257658

    Santander, Cantabria, 39008, Spain

  • Hospital Universitario Vall de Hebron /ID# 257652

    Barcelona, 08035, Spain

  • Hospital Universitario Virgen del Rocio /ID# 257657

    Seville, 41013, Spain

  • Hospital Universitario y Politecnico La Fe /ID# 257655

    Valencia, 46026, Spain

  • Hospital da Luz Lisboa /ID# 257983

    Lisbon, 1500-650, Portugal

  • ICOT Istituto Marco Pasquali /ID# 258621

    Latina, 04100, Italy

  • INEP medical s.r.o. /ID# 257669

    Prague, 186 00, Czechia

  • IRCCS Ospedale San Raffaele /ID# 258592

    Milan, Milano, 20132, Italy

  • Ikeda Neurosurgical Clinic /ID# 259085

    Kasuga-shi, Fukuoka, 816-0824, Japan

  • Indywidualna Praktyka Lekarska dr hab. med. Anna Szczepanska-Szerej /ID# 258281

    Lublin, Lublin Voivodeship, 20-582, Poland

  • Instytut Zdrowia Dr Boczarska Jedynak /ID# 258248

    Oświęcim, Lesser Poland Voivodeship, 32-600, Poland

  • Istituto Auxologico Italiano - Irccs /ID# 258623

    Milan, Milano, 20145, Italy

  • Istituto Neurologico Mediterraneo Neuromed /ID# 258593

    Pozzilli, Isernia, 86077, Italy

  • Javorszky Odon Korhaz /ID# 258969

    Vác, Pest County, 2600, Hungary

  • Jessa Ziekenhuis /ID# 257578

    Hasselt, Limburg, 3500, Belgium

  • Jiangxi Pingxiang Peoples Hospital /ID# 258652

    Pingxiang, Jiangxi, 337055, China

  • Kangbuk Samsung Hospital /ID# 258001

    Seoul, Seoul Teugbyeolsi, 03181, South Korea

  • Karolinska Universitetssjukhuset - Huddinge /ID# 258837

    Huddinge, Stockholm County, 141 57, Sweden

  • Kopfschmerzzentrum - Frankfurt /ID# 258019

    Frankfurt am Main, Hesse, 65929, Germany

  • Kuang-Tien General Hospital /ID# 258063

    Taichung, Taichung, 433, Taiwan

  • Lanzhou University Second Hospital /ID# 259667

    Lanzhou, Gansu, 730030, China

  • Linden Spolka z Ograniczona Odpowiedzialnoscia Spolka Komandytowa /ID# 258283

    Krakow, Lesser Poland Voivodeship, 30-105, Poland

  • Linkou Chang Gung Memorial Hospital /ID# 259171

    Taoyuan City, 333, Taiwan

  • Liptovska nemocnica s poliklinikou MUDr. Ivana Stodolu Liptovsky Mikulas /ID# 258315

    Liptovský Mikuláš, Žilina Region, 031 23, Slovakia

  • MIGRE Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak /ID# 258287

    Wroclaw, 52-210, Poland

  • MUDr. Beata Dupejova neurologicka ambulancia s.r.o. /ID# 257901

    Banská Bystrica, 974 04, Slovakia

  • Nagaseki Headache Clinic /ID# 259214

    Kai, Yamanashi, 400-0124, Japan

  • NeuroHK s.r.o. /ID# 257671

    Hradec Králové, 500 09, Czechia

  • Neurologicka a algeziologicka ambulancia, SANERA /ID# 259176

    Prešov, Presov, 080 01, Slovakia

  • Neurology Clinic /ID# 258835

    Stockholm, Stockholm County, 114 33, Sweden

  • Neuropraxis Muenchen Sued /ID# 258077

    Unterhaching, Bavaria, 82008, Germany

  • North Coast Medical Ltd - Newquay Health Centre /ID# 260019

    Newquay, Cornwall, TR7 1RU, United Kingdom

  • Nowon Eulji Medical Center, Eulji University /ID# 258000

    Seoul, Seoul Teugbyeolsi, 01830, South Korea

  • Optimuskliniken /ID# 258834

    Upplands Vasby, Stockholm County, 194 61, Sweden

  • Ospedale San Paolo - ASL2 /ID# 258622

    Savona, 17100, Italy

  • Peking University First Hospital /ID# 258672

    Xicheng District, Beijing Municipality, 100034, China

  • Peking University Third Hospital /ID# 259573

    Beijing, Beijing Municipality, 100191, China

  • Penta Hospitals Badania Kliniczne /ID# 258250

    Wroclaw, Lower Silesian Voivodeship, 54-429, Poland

  • Poliklinika Bezrucova (Cliniq s.r.o.) /ID# 257961

    Bratislava, Bratislava Region, 811 09, Slovakia

  • Praglandia /ID# 257667

    Prague, Praha 5, 150 00, Czechia

  • Primary Care Sheffield /ID# 259448

    Sheffield, S9 4EU, United Kingdom

  • Queen Elizabeth University Hospital - NHS Greater Glasgow and Clyde /ID# 259384

    Glasgow, Lanarkshire, G51 4TF, United Kingdom

  • Re:Cognition Health - Guildford /ID# 258188

    Guildford, GU2 7YD, United Kingdom

  • Re:Cognition Health Birmingham /ID# 258186

    Birmingham, B16 8LT, United Kingdom

  • Re:Cognition Health Bristol /ID# 258187

    Bristol, BS32 4SY, United Kingdom

  • S-Medicon Kft /ID# 258547

    Budapest, 1138, Hungary

  • Schmerzklinik Kiel /ID# 258005

    Kiel, Schleswig-Holstein, 24149, Germany

  • Second Hospital of Shanxi Medical University /ID# 259669

    Taiyuan, Shanxi, 030001, China

  • Semmelweis Egyetem /ID# 258546

    Budapest, 1085, Hungary

  • Semmelweis Egyetem /ID# 258800

    Budapest, 1085, Hungary

  • Sendai Headache and Neurology Clinic Medical Corporation /ID# 258862

    Sendai, Miyagi, 982-0014, Japan

  • Seoul National University Hospital /ID# 258002

    Seoul, Seoul Teugbyeolsi, 03080, South Korea

  • Shaanxi Provincial PeopleS Hospital /ID# 259529

    Xi'an, Shaanxi, 710054, China

  • Silmedic Sp. z o.o. /ID# 258249

    Katowice, Silesian Voivodeship, 40-282, Poland

  • Skaneuro Privatmottagning /ID# 258833

    Lund, Skåne County, 227 33, Sweden

  • Solumed Centrum Medyczne /ID# 258288

    Poznan, Greater Poland Voivodeship, 60-529, Poland

  • St Pancras Clinical Research - Chester /ID# 277704

    Chester, Cheshire, CH2 1HX, United Kingdom

  • St Pancras Clinical Research - London /ID# 258183

    London, Greater London, EC2Y 8EA, United Kingdom

  • Studienzentrum Nord-West /ID# 258024

    Westerstede, Lower Saxony, 26655, Germany

  • Taipei Veterans General Hospital /ID# 258062

    Taipei City, Taipei, 11217, Taiwan

  • Tatsuoka Neurology Clinic /ID# 258771

    Kyoto, 600-8811, Japan

  • The Adam Practice /ID# 258190

    Poole, Dorset, BH15 4JQ, United Kingdom

  • The Affiliated Hospital of Guizhou Medical University /ID# 259536

    Guiyang, Guizhou, 550004, China

  • The First Affiliated Hospital of Soochow University /ID# 258783

    Suzhou, Jiangsu, 215031, China

  • The First Affiliated Hospital of Wenzhou Medical University /ID# 258939

    Wenzhou, Zhejiang, 325000, China

  • The First Affiliated Hospital of Xiamen University /ID# 259576

    Xiamen, Fujian, 361003, China

  • The First Hospital of Jilin University /ID# 259585

    Changchun, Jilin, 130021, China

  • The Second Affiliated Hospital of Guangzhou Medical University /ID# 258638

    Guangzhou, Guangdong, 510260, China

  • The Second Affiliated Hospital of Nanjing Medical University /ID# 258648

    Nanjing, Jiangsu, 210011, China

  • The Second Affiliated Hospital of Soochow University /ID# 259551

    Suzhou, Jiangsu, 215004, China

  • The Second Affiliated Hospital of Zhejiang University School of Medicine /ID# 258860

    Hangzhou, Zhejiang, 310009, China

  • The Second Xiangya Hospital Of Central South University /ID# 260623

    Changsha, Hunan, 410011, China

  • The Second hospital of Jilin university /ID# 258556

    Changchun, Jilin, 130022, China

  • The Third Xiangya Hospital of Central South University /ID# 258787

    Changsha, Hunan, 410013, China

  • The University Of Hong Kong - Shenzhen Hospital /ID# 258462

    Shenzhen, Guangdong, 518053, China

  • The University of Nottingham Health Service /ID# 259380

    Nottingham, NG7 2QW, United Kingdom

  • The first affiliated hospital of bengbu medical college /ID# 258758

    Bengbu, Anhui, 233004, China

  • The first people's Hospital Affiliated to Shanghai Jiaotong University /ID# 259554

    Shanghai, 200080, China

  • Tianjin Medical University General Hospital /ID# 259513

    Tianjin, Tianjin Municipality, 300052, China

  • Tianjin People's Hospital /ID# 258625

    Tianjin, Tianjin Municipality, 300120, China

  • Tokyo Dental College Ichikawa General Hospital /ID# 259570

    Ichikawa-shi, Chiba, 272-0824, Japan

  • Tokyo Headache Clinic /ID# 258534

    Shibuya-ku, Tokyo, 151-0051, Japan

  • Tominaga Clinic - Osaka /ID# 258553

    Osaka, Osaka, 556-0015, Japan

  • Tri-Service General Hospital /ID# 258064

    Taipei, 11490, Taiwan

  • UNO Medical Trials /ID# 259186

    Budapest, 1135, Hungary

  • Umenotsuji Clinic /ID# 258717

    Kochi, Kochi, 780-8011, Japan

  • Unidade Local de Saude da Arrabida, EPE /ID# 258139

    Setúbal, 2910-446, Portugal

  • Unidade Local de Saude de Almada-Seixal, EPE /ID# 257987

    Almada, Setúbal District, 2805-267, Portugal

  • Unidade Local de Saude de Santa Maria /ID# 257989

    Lisbon, 1649-035, Portugal

  • Unidade Local de Saude de Santo Antonio /ID# 258140

    Porto, 4099-003, Portugal

  • Unidade Local de Saude do Alto Ave, EPE /ID# 257986

    Guimarães, Braga District, 4835-044, Portugal

  • Univ. of Bologna-IRCCS-Istituto delle Scienze Neurologiche /ID# 261089

    Bologna, 40126, Italy

  • Universitaetsklinikum Duesseldorf /ID# 258078

    Düsseldorf, North Rhine-Westphalia, 40225, Germany

  • Universitaetsklinikum Essen /ID# 258023

    Essen, 45147, Germany

  • Universitair Ziekenhuis Antwerpen /ID# 257582

    Edegem, Antwerpen, 2650, Belgium

  • Universitair Ziekenhuis Brussel /ID# 257584

    Jette, Brussels Capital, 1090, Belgium

  • University Hospital Bratislava - Hospital ak. L. Derera /ID# 257947

    Bratislava, Bratislava Region, 831 01, Slovakia

  • Univerzitna nemocnica - Nemocnica svateho Michala a.s. /ID# 257909

    Bratislava, Bratislava Region, 811 08, Slovakia

  • Usuda Clinic Of Internal Medicine /ID# 260422

    Setagaya-ku, Tokyo, 156-0043, Japan

  • Velocity Clinical Research - Wiesbaden /ID# 258020

    Wiesbaden, Hesse, 65189, Germany

  • Vestra Clinics s.r.o. /ID# 259022

    Rychnov nad Kněžnou, 516 01, Czechia

  • Vitamed Galaj i Cichomski Sp.j. /ID# 258278

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-079, Poland

  • Vitos Orthopaedische Klinik Kassel gemeinnuetzige GmbH /ID# 258008

    Kassel, 34131, Germany

  • West China Hospital, Sichuan University /ID# 258664

    Chengdu, Sichuan, 610041, China

  • Xuanwu Hospital Capital Medical University /ID# 258510

    Beijing, Beijing Municipality, 100053, China

  • Yonsei University Health System Severance Hospital /ID# 257998

    Seoul, 03722, South Korea

  • Zhengzhou People's Hospital /ID# 258670

    Zhengzhou, Henan, 450012, China

  • Zhuzhou Central Hospital /ID# 260076

    Zhuzhou, Hunan, 412007, China

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