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MRI reveals Acupuncture's brain impact in migraine sufferers

NCT ID NCT04157192

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Nīmes Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how acupuncture affects the brain in people with migraine without aura. Forty adults received either real acupuncture or a sham (fake) version, and their brains were scanned with MRI before and after treatment. The goal was to see if real acupuncture causes different brain changes than the placebo, helping explain how it might reduce migraine attacks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

May 2022

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All patients with two to eight bouts of migraine without an aura per month * All patient aged (≥) 18 to (≤) 60 years old * All patients who have not had a bout of migraine in the last 24 hours * All patients who have given free informed consent and have signed the consent form. * All patients who are affiliated to or beneficiaries of a health insurance scheme * All patients available for a two-month follow-up Exclusion Criteria: * All patients with migraine which is secondary to a neurological, neuropsychiatric, or vascular disorder * All patients suffering from diabetes * All patients with a past history of alcohol or drug abuse * All patients with contraindications for an MRI scan * All patients on antidepressants or Botox. * All patients already taking part in Category 1 research involving the human person * All patients on an exclusion period determined by another study * All patients placed under judicial protection, guardianship, or supervision * All patients for whom it is impossible to give the subject clear information * All patients who are pregnant, about to give birth or breastfeeding * All patient who have received botulinum toxin in the past year * All patient who have undergone antidepressant treatment in the last 2 months * All patient who have started a background migraine treatment for less than 3 months * All patient who have more than 14 migraine days per month

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Conditions

The condition(s) this trial relates to.

migraine without aura

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acupuncture therapy Migraine without aura

Contacts and locations

Locations

  • CHU de Nîmes

    Nîmes, 30029, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.