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Transplant vs. standard care: which protects sickle cell Kids' brains better Long-Term?

NCT ID NCT05053932

Knowledge-focused Sponsor: Centre Hospitalier Intercommunal Creteil Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study followed 67 children with sickle cell disease who had a high risk of stroke. Researchers compared those who received a bone marrow transplant to those who got standard care, checking brain scans and thinking skills 9-10 years later. The goal was to see which approach better prevents long-term brain damage and artery narrowing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

67 people

The number who actually took part.

Started

Oct 2022

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Population concerned 67 patients included in 2011-2013 in the DREPAGREFFE protocol \[NCT 01340404\]

Ages

13 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient of legal age or minor who participated in the DREPAGREFFE research protocol \[NCT 01340404\] between December 2010 and June 2013, * Having read and understood the information letter Exclusion Criteria: * Refusal to participate * Patient deceased

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Conditions

The condition(s) this trial relates to.

brain ischemia cerebral infarction Constriction, Pathologic sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebral ischemia Sickle cell disease Stenosis

Contacts and locations

Locations

  • CH de Pau

    Pau, 64000, France

  • CHU de Lyon

    Lyon, 69737, France

  • CHU de Montpellier

    Montpellier, 34295, France

  • CHU de Rennes

    Rennes, 35033, France

  • CHU de la Guadeloupe

    La Guadeloupe, 97110, France

  • Centre Hospitalier Intercommunal de Créteil

    Créteil, 94000, France

  • Groupe hospitalier Pellegrin

    Bordeaux, 33000, France

  • Hôpital Bicêtre AP-HP

    Le Kremlin-Bicêtre, 94270, France

  • Hôpital Hautepierre

    Strasbourg, 67200, France

  • Hôpital Henri Monr - APHP

    Créteil, 94000, France

  • Hôpital Necker - AP-HP

    Paris, 75015, France

  • Hôpital Robert Debré AP-HP

    Paris, IDF, 75019, France

  • Hôpital de la Timone

    Marseille, 13005, France

  • IHOPe

    Lyon, 69008, France

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