Transplant vs. standard care: which protects sickle cell Kids' brains better Long-Term?

NCT ID NCT05053932

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study followed 67 children with sickle cell disease who had a high risk of stroke. Researchers compared those who received a bone marrow transplant to those who got standard care, checking brain scans and thinking skills 9-10 years later. The goal was to see which approach better prevents long-term brain damage and artery narrowing.

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Conditions

The condition(s) this trial relates to.

brain ischemia cerebral infarction Constriction, Pathologic sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CH de Pau

    Pau, 64000, France

  • CHU de Lyon

    Lyon, 69737, France

  • CHU de Montpellier

    Montpellier, 34295, France

  • CHU de Rennes

    Rennes, 35033, France

  • CHU de la Guadeloupe

    La Guadeloupe, 97110, France

  • Centre Hospitalier Intercommunal de Créteil

    Créteil, 94000, France

  • Groupe hospitalier Pellegrin

    Bordeaux, 33000, France

  • Hôpital Bicêtre AP-HP

    Le Kremlin-Bicêtre, 94270, France

  • Hôpital Hautepierre

    Strasbourg, 67200, France

  • Hôpital Henri Monr - APHP

    Créteil, 94000, France

  • Hôpital Necker - AP-HP

    Paris, 75015, France

  • Hôpital Robert Debré AP-HP

    Paris, IDF, 75019, France

  • Hôpital de la Timone

    Marseille, 13005, France

  • IHOPe

    Lyon, 69008, France