Transplant vs. standard care: which protects sickle cell Kids' brains better Long-Term?

NCT ID NCT05053932

Completed Knowledge-focused Sponsor: Centre Hospitalier Intercommunal Creteil Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study followed 67 children with sickle cell disease who had a high risk of stroke. Researchers compared those who received a bone marrow transplant to those who got standard care, checking brain scans and thinking skills 9-10 years later. The goal was to see which approach better prevents long-term brain damage and artery narrowing.

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Conditions

The condition(s) this trial relates to.

brain ischemia cerebral infarction Constriction, Pathologic sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CEREBRAL ISCHEMIA SICKLE CELL DISEASE STENOSIS

Contacts and locations

Locations

CH de Pau

Pau, 64000, France
CHU de Lyon

Lyon, 69737, France
CHU de Montpellier

Montpellier, 34295, France
CHU de Rennes

Rennes, 35033, France
CHU de la Guadeloupe

La Guadeloupe, 97110, France
Centre Hospitalier Intercommunal de Créteil

Créteil, 94000, France
Groupe hospitalier Pellegrin

Bordeaux, 33000, France
Hôpital Bicêtre AP-HP

Le Kremlin-Bicêtre, 94270, France
Hôpital Hautepierre

Strasbourg, 67200, France
Hôpital Henri Monr - APHP

Créteil, 94000, France
Hôpital Necker - AP-HP

Paris, 75015, France
Hôpital Robert Debré AP-HP

Paris, IDF, 75019, France
Hôpital de la Timone

Marseille, 13005, France
IHOPe

Lyon, 69008, France

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