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New minimally invasive procedure could change outcomes for bleeding stroke patients

NCT ID NCT07187687

Disease control Sponsor: Xuanwu Hospital, Beijing Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 10, 2026 · Updated 4 times

Summary

This study compares standard medical care to a new, less invasive surgery for people with a severe bleeding stroke. The surgery uses a small tube to drain the blood clot and delivers clot-busting medicine directly into the brain. Researchers want to see if this approach helps patients recover better and regain more function within 6 months. The trial is for adults with a large brain bleed who can be treated within 8 hours of symptoms starting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 750 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 18 years; 2. Pre-randomization head CT demonstrating an acute, spontaneous, primary ICH; 3. ICH volume ≥ 20mL as calculated by the ABC/2 method; 4. The randomization can be completed within 8 hours after the onset of stroke symptoms (or the time last known to be well), and study intervention can reasonably be initiated within 4 hours after randomization. 5. Historical Modified Rankin Score 0 or 1; 6. Obtain informed consent from patient or legal representative. Exclusion Criteria: 1. Infratentorial intraparenchymal hemorrhage including midbrain, pontine, or cerebellar; 2. Ruptured aneurysm, arteriovenous malformation (AVM), vascular anomaly, Moyamoya disease, venous sinus thrombosis, mass or tumor, hemorrhagic conversion of an ischemic infarct, tumor stroke, recurrence of a recent (\<1 year) ICH, as diagnosed with radiographic imaging; 3. Presence of spot sign in CT angiography; 4. Blood pressure control before randomization is ineffective, systolic blood pressure \> 220 mmHg; 5. Irreversible impaired brain stem function (bilateral fixed, dilated pupils and extensor motor posturing), GCS ≤ 4; 6. Hemorrhage with apparent midbrain extension with third nerve palsy or dilated and non-reactive pupils. Other (supranuclear) gaze abnormalities are not exclusions; 7. Intraventricular extension of the Hemorrhage is visually estimated to involve \>50% of either of the lateral ventricles; 8. Any irreversible coagulopathy or known clotting disorder. 9. Platelet count \< 750,000, INR \> 1.4 after correction 10. Patients requiring long-term anti-coagulation that needs to be initiated \< 30 days from index ICH; 11. Use of 2 or more antithrombotic drugs prior to symptom onset; 12. Patients with a mechanical heart valve; 13. Positive urine or serum pregnancy test in female subjects without documented history of surgical sterilization or is post-menopausal; 14. Urokinase allergy; 15. Any concurrent serious illness that would interfere with the outcome assessments including hepatic, renal, gastroenterologic, respiratory, cardiovascular, endocrinologic, immunologic, and hematologic disease; 16. Inability or unwillingness of patient or legal representative to give written informed consent; 17. Known life-expectancy of less than 6 months; 18. Participation in a concurrent interventional medical investigation or clinical trial.

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Conditions

The condition(s) this trial relates to.

brain disorder cerebrovascular disorder Hemorrhage intracerebral hemorrhage Intracranial Hemorrhages

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intracerebral hemorrhage

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    69 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Affiliated Hospital of Hebei University of Engineering

    NOT_YET_RECRUITING

    Hebei, China

  • Affiliated Hospital of Inner Mongolia Medical University

    RECRUITING

    Hohhot, China

  • Affiliated Hospital of Nantong University

    RECRUITING

    Nantong, China

  • Baotou Central Hospital

    RECRUITING

    Baotou, China

  • Beijing Chao-Yang Hospital, Capital Medical University

    RECRUITING

    Beijing, China

  • Beijing Daxing District People's Hospital

    RECRUITING

    Beijing, China

  • Beijing Fengtai You'anmen Hospital

    RECRUITING

    Beijing, China

  • Beijing Friendship Hospital, Capital Medical University

    RECRUITING

    Beijing, China

  • Bozhou city people's hospital

    RECRUITING

    Bozhou, China

  • Center Hospital of Nanyang

    RECRUITING

    Nanyang, China

  • Central People's Hospital of Siping City

    RECRUITING

    Siping, China

  • Changsha Central Hospital

    RECRUITING

    Changsha, China

  • Changzhi Medical College Affiliated Heji Hospital

    RECRUITING

    Changzhi, China

  • Chifeng Municipal Hospital

    RECRUITING

    Chifeng, China

  • Chongqing Emergency Medical Service

    RECRUITING

    Chongqing, China

  • Chongqing Red Cross Hospital

    NOT_YET_RECRUITING

    Chongqing, China

  • First Affiliated Hospital of Dalian Medical University

    RECRUITING

    Dalian, China

  • First Affiliated Hospital of Gannan Medical University

    RECRUITING

    Gannan, China

  • First Affiliated Hospital of Xinjiang Medical University

    RECRUITING

    Ürümqi, China

  • First Hospital of Shanxi Medical University

    RECRUITING

    Shanxi, China

  • Fujian Zhangzhou Municipal Hospital

    RECRUITING

    Fujian, China

  • Fuxin Second People\'s Hospital

    NOT_YET_RECRUITING

    Fuxin, China

  • Fuyang People's Hospital

    RECRUITING

    Fuyang, China

  • Guangdong Provincial People's Hospital

    RECRUITING

    Guangdong, Yuexiu, China

  • Guiyang Second People's Hospital

    NOT_YET_RECRUITING

    Guiyang, China

  • Handan Central Hospital

    RECRUITING

    Handan, China

  • Henan Provincial People's Hospital

    RECRUITING

    Zhengzhou, China

  • Huizhou First People's Hospital

    NOT_YET_RECRUITING

    Huizhou, China

  • Jinan City People's Hospital

    RECRUITING

    Jinan, China

  • Jinan Hospital of Xuanwu Hospital, Capital Medical University

    RECRUITING

    Jinan, China

  • Liaocheng Brain Hospital

    NOT_YET_RECRUITING

    Liaocheng, China

  • Peking University Aerospace Central Hospital

    NOT_YET_RECRUITING

    Beijing, China

  • People's Hospital of Chongqing Banan District

    RECRUITING

    Chongqing, China

  • Quzhou People's Hospital

    RECRUITING

    Quzhou, China

  • Shanghai Fourth People's Hospital Affiliated to Tongji University

    RECRUITING

    Shanghai, China

  • Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University

    RECRUITING

    Shanghai, China

  • Shanghai Tenth People's Hospital

    RECRUITING

    Shanghai, China

  • Shunyi District Hospital in Beijing

    RECRUITING

    Beijing, China

  • Suining Central Hospital

    RECRUITING

    Sichuan, China

  • Taihe Hospital in Shiyan City

    RECRUITING

    Shiyan, China

  • Tangshan Workers' Hospita

    RECRUITING

    Tangshan, China

  • The First Affiliated Hospital of Anhui Medical University

    RECRUITING

    Hefei, China

  • The First Affiliated Hospital of China Medical University

    RECRUITING

    Shenyang, China

  • The First Affiliated Hospital of Nanchang University

    RECRUITING

    Nanchang, China

  • The First Affiliated Hospital of Ningbo University

    RECRUITING

    Ningbo, China

  • The First Affiliated Hospital of Wenzhou Medical University

    RECRUITING

    Wenzhou, China

  • The First Affiliated Hospital of Xiamen University

    RECRUITING

    Xiamen, China

  • The First Hospital of China Medical University

    RECRUITING

    Shenyang, China

  • The First Hospital of Harbin Medical University

    NOT_YET_RECRUITING

    Harbin, China

  • The First Hospital of Hebei Medical University

    RECRUITING

    Shijiazhuang, China

  • The First People Hospital of Yunnan Province

    RECRUITING

    Kunming, China

  • The First People's Hospital of Changzhou

    RECRUITING

    Changzhou, China

  • The First People's Hospital of Nanning

    NOT_YET_RECRUITING

    Nanning, China

  • The Fourth People's Hospital of Zigong City

    RECRUITING

    Zigong, China

  • The Second Affiliated Hospital of Shandong First Medical University

    RECRUITING

    Tai’an, China

  • The Second Affiliated Hospital of Wenzhou Medical University

    NOT_YET_RECRUITING

    Wenzhou, China

  • The Second Affiliated Hospital of Zhengzhou University

    RECRUITING

    Zhengzhou, China

  • The Seventh Affiliated Hospital of Southern Medical University

    NOT_YET_RECRUITING

    Guangdong, China

  • Third People's Hospital of Hainan Province

    RECRUITING

    Sanya, China

  • Tianjin Huanhu Hospital

    RECRUITING

    Tianjin, China

  • Tibet People's Hospital

    RECRUITING

    Lasa, China

  • University of Chinese Academy of Sciences Ningbo Huamei Hospital

    RECRUITING

    Ningbo, China

  • Weifang People's Hospital

    RECRUITING

    Weifang, China

  • Xiangyang Central Hospital

    RECRUITING

    Xiangyang, China

  • Xingan League People's Hospita

    RECRUITING

    Neimeng, China

  • Xuanwu Hospital, Capital Medical University

    RECRUITING

    Beijing, China

  • Yanan Medical College of Yanan University

    RECRUITING

    Yan’an, China

  • Yichang Central People's Hospital

    NOT_YET_RECRUITING

    Yichang, China

  • Zhangjiajie City People's Hospital

    RECRUITING

    Zhangjiajie, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.