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Could a daily pill stop chronic migraines in teens?

NCT ID NCT06810505

Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 6 times

Summary

This study tests whether the drug atogepant (Qulipta) can safely prevent chronic migraines in teenagers aged 12 to 17. About 420 teens with chronic migraine will take either atogepant or a placebo pill daily for 12 weeks. Researchers will track side effects and changes in monthly migraine days to see if the drug works better than a placebo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
atogepant (oral tablet, also known as Qulipta or Aquipta)
What this could lead to
If it works, this could provide a new preventive treatment option for chronic migraine in teenagers, reducing the number of migraine days per month.
What could go wrong
This is an early-phase study in teens, and atogepant is already approved for adults. However, results may differ in adolescents, and side effects or lack of effectiveness compared to placebo are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 420 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Mar 2031

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * History of chronic migraine with or without aura consistent with a diagnosis according to the International Classification of Headache Disorders, 3rd Edition (ICHD-3) (2018) for at least 6 months as of Visit 1. * During the last 28 days of the screening/baseline period, and as per eDiary: * Participant must have completed the eDiary for a minimum of 20 out of 28 days. * Participant has \>= 15 headache days. * Participant has \>= 8 migraine days. Exclusion Criteria: * Clinically significant hypertension per investigator's judgment. * History of any clinically significant hematologic, endocrine, pulmonary, renal, hepatic, gastrointestinal, cardiovascular or neurologic disease.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic migraine

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    59 sites in 10 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Accellacare - Long Beach /ID# 270398

    RECRUITING

    Long Beach, California, 90807, United States

  • Access Clinical Trials Inc /ID# 270280

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • Advanced Research Center /ID# 270257

    RECRUITING

    Anaheim, California, 92805, United States

  • Alpine Research Organization - Clinton /ID# 276527

    RECRUITING

    Clinton, Utah, 84015, United States

  • Athleticomed Sp. z o.o /ID# 270243

    RECRUITING

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-752, Poland

  • Auzmer Research /ID# 271158

    COMPLETED

    Lakeland, Florida, 33813, United States

  • Canisius-Wilhelmina Ziekenhuis /ID# 270374

    RECRUITING

    Nijmegen, Gelderland, 6532 SZ, Netherlands

  • Caribbean Medical Research Center Headlands /ID# 271300

    COMPLETED

    San Juan, 00918-3501, Puerto Rico

  • Cct Research - Papillion Research Center /ID# 270393

    RECRUITING

    Papillion, Nebraska, 68046, United States

  • Clinical Research Center Medic-R /ID# 270235

    RECRUITING

    Poznan, Greater Poland Voivodeship, 60-848, Poland

  • Clinpoint Trials /ID# 270261

    RECRUITING

    Waxahachie, Texas, 75165, United States

  • Deaconess Midtown Hospital /ID# 270572

    RECRUITING

    Evansville, Indiana, 47710, United States

  • Dent Neurologic Institute - Amherst /ID# 270260

    RECRUITING

    Amherst, New York, 14226, United States

  • Earle Research /ID# 270424

    RECRUITING

    Houston, Texas, 77058, United States

  • Encore Medical Research - Weston /ID# 271139

    RECRUITING

    Weston, Florida, 33331, United States

  • Excell Research /ID# 270258

    RECRUITING

    Oceanside, California, 92056, United States

  • Fondazione IRCCS Istituto Neurologico Carlo Besta /ID# 270756

    RECRUITING

    Milan, Milano, 20133, Italy

  • Frontier Clinical Research - Kingwood /ID# 271053

    RECRUITING

    Kingwood, West Virginia, 26537, United States

  • Frontier Clinical Research - Scottdale /ID# 270854

    RECRUITING

    Scottdale, Pennsylvania, 15683, United States

  • Frontier Clinical Research - Smithfield /ID# 270849

    RECRUITING

    Smithfield, Pennsylvania, 15478, United States

  • Great Ormond Street Children's Hospital /ID# 271550

    RECRUITING

    London, Greater London, WC1N 3HZ, United Kingdom

  • HagaZiekenhuis /ID# 270379

    RECRUITING

    The Hague, South Holland, 2545 AA, Netherlands

  • Headache Wellness Center /ID# 270568

    COMPLETED

    Greensboro, North Carolina, 27405, United States

  • Healthy Perspectives - Innovate Mental Health Services /ID# 270847

    RECRUITING

    Nashua, New Hampshire, 03060, United States

  • Herlev Hospital /ID# 270482

    RECRUITING

    Herlev, Capital Region, 2730, Denmark

  • Highland Clinical Research /ID# 270281

    RECRUITING

    Salt Lake City, Utah, 84124, United States

  • Hospital da Luz /ID# 277991

    RECRUITING

    Lisbon, Lisbon District, 1500-650, Portugal

  • Konan Medical Center /ID# 270486

    RECRUITING

    Kobe, Hyōgo, 658-0064, Japan

  • London Health Sciences Centre - Victoria Hospital & Children's Hospital /ID# 270659

    RECRUITING

    London, Ontario, N6A 5W9, Canada

  • Lumos Clinical Research Center /ID# 270582

    RECRUITING

    San Jose, California, 95124, United States

  • MIGRE Polskie Centrum Leczenia Migreny /ID# 270239

    RECRUITING

    Wroclaw, Lower Silesian Voivodeship, 52-210, Poland

  • McGill University Health Centre - Glen Site /ID# 270662

    COMPLETED

    Montreal, Quebec, H4A 3J1, Canada

  • Medway Maritime Hospital /ID# 271885

    RECRUITING

    Gillingham, Kent, ME7 5NY, United Kingdom

  • Michigan Headache & Neurological Institute /ID# 270942

    RECRUITING

    Ann Arbor, Michigan, 48104, United States

  • My Preferred Research /ID# 270312

    RECRUITING

    Miami, Florida, 33155, United States

  • Nagaseki Headache Clinic /ID# 271699

    RECRUITING

    Kai, Yamanashi, 400-0124, Japan

  • Neuro Pain Research Center /ID# 271048

    RECRUITING

    Fresno, California, 93710, United States

  • Northwest Florida Clinical Research Group, LLC /ID# 270833

    RECRUITING

    Gulf Breeze, Florida, 32561, United States

  • Oha-Med Sp. Z O.O /ID# 270242

    RECRUITING

    Warsaw, Masovian Voivodeship, 01-018, Poland

  • Ospedale Pediatrico Bambino Gesu /ID# 270759

    RECRUITING

    Rome, Roma, 00165, Italy

  • Pantheon Clinical Research /ID# 270259

    RECRUITING

    Bountiful, Utah, 84010, United States

  • Pediatric Neurology & Epilepsy Center Of Central Florida - Winter Park /ID# 275263

    RECRUITING

    Winter Park, Florida, 32789, United States

  • Preferred Research Partners - Fayetteville /ID# 270419

    COMPLETED

    Fayetteville, Arkansas, 72703, United States

  • Preferred Research Partners /ID# 270389

    RECRUITING

    Little Rock, Arkansas, 72211, United States

  • Proven Endpoints LLC /ID# 270269

    RECRUITING

    Ridgeland, Mississippi, 39157, United States

  • Regionshospitalet Godstrup /ID# 270481

    RECRUITING

    Herning, Central Jutland, 7400, Denmark

  • Rehabilitation and Neurological Services /ID# 270782

    RECRUITING

    Huntsville, Alabama, 35805, United States

  • Royal Aberdeen Children's Hospital /ID# 271664

    RECRUITING

    Aberdeen, Scotland, AB25 2ZG, United Kingdom

  • Rozsavolgyi Rendelo-Ceba Bt. /ID# 271500

    RECRUITING

    Budapest, 1141, Hungary

  • Semmelweis Egyetem /ID# 271219

    RECRUITING

    Budapest, 1085, Hungary

  • Specjalistyczne Gabinety Sp. z o.o /ID# 270238

    RECRUITING

    Krakow, Lesser Poland Voivodeship, 30-539, Poland

  • Stepping Hill Hospital-Stockport NHS foundation trust /ID# 271883

    RECRUITING

    Stockport, SK2 7JE, United Kingdom

  • Sunwise Clinical Research /ID# 270431

    RECRUITING

    Walnut Creek, California, 94596, United States

  • Tanaka Neurosurgery & Headache Clinic /ID# 271346

    RECRUITING

    Kagoshima, 890-0052, Japan

  • Tendo Brain Clinic /ID# 271410

    RECRUITING

    Tendo-shi, Yamagata, 994-0083, Japan

  • Tokyo Headache Clinic /ID# 271610

    RECRUITING

    Shibuya-ku, Tokyo, 151-0051, Japan

  • Tokyo Medical University Hospital /ID# 270487

    RECRUITING

    Shinjuku-ku, Tokyo, 160-0023, Japan

  • Tominaga Clinic - Osaka /ID# 270483

    RECRUITING

    Osaka, Osaka, 556-0015, Japan

  • UT Health Austin at Dell Childrens Neurology Clinic /ID# 270577

    RECRUITING

    Austin, Texas, 78723-3079, United States

  • Umenotsuji Clinic /ID# 270484

    RECRUITING

    Kochi, Kochi, 780-8011, Japan

  • Unidade Local de Saude de Almada-Seixal, EPE /ID# 278092

    RECRUITING

    Almada, Setúbal District, 2805-267, Portugal

  • Unidade Local de Saude de Coimbra /ID# 277993

    RECRUITING

    Coimbra, 3000-075, Portugal

  • Unidade Local de Saude de Santa Maria /ID# 277997

    RECRUITING

    Lisbon, 1649-035, Portugal

  • Unidade Local de Saude de Santo Antonio /ID# 278090

    RECRUITING

    Porto, 4099-003, Portugal

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