Heart attack survivors: shorter blood thinner course may be safer and effective
NCT ID NCT07507500
First seen Jun 27, 2026 · Last updated Sep 10, 2026 · Updated 2 times
Summary
This study involves 8,100 adults who had a heart attack and received a stent. It compares different approved blood-thinning strategies to see which one best prevents another heart attack, stroke, or death while also reducing serious bleeding. Participants will either receive a shorter course of dual therapy followed by one drug, or the standard 12-month dual therapy. The goal is to improve long-term outcomes without increasing risks.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
About 8,100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Sep 2026
- Expected to finish
-
Jan 2030
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * ≥18 years old * Admitted because of an acute MI (either STEMI or NSTEMI). * Invasive management during index admission with successful PCI. * Able to consent. Exclusion Criteria: * Indication for oral anticoagulation therapy. * Intolerance, contraindication or known allergy to either aspirin, prasugrel or ticagrelor. * Prior history of ischaemic or haemorrhagic stroke or transient ischaemic attack. * Patients with active bleeding or known bleeding disorders. * Patients with known moderate or severe hepatic dysfunction (Child-Pugh Class B or Class C). * Known intracranial aneurism, arteriovenous malformation or neoplasm. * Patients with chronic kidney disease requiring dialysis. * Any disorder that may interfere with drug absorption. * Pregnancy or current lactation. * Concomitant use of potent CYP3A inhibitors or inducers. * Planned elective surgery that cannot be deferred 12 months before randomization, requiring interruption of antiplatelet therapy. * Any medical condition that, in the investigator´s judgment, would seriously limit life expectancy (less than one year) * Active participation in other clinical trials.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Acute myocardial infarction are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
5 sites in 5 countries. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Fundación Jiménez Díaz University Hospital
RECRUITINGMadrid, Spain
-
Mater Private Network Dublin
NOT_YET_RECRUITINGDublin, Ireland
-
Oslo University Hospital, Ullevål.
NOT_YET_RECRUITINGOslo, Norway
-
Paula Stradiņa klīniskā universitates slimnīca
NOT_YET_RECRUITINGRiga, Latvia
-
Saint John Paul II Hospital in Cracow
NOT_YET_RECRUITINGKrakow, Poland
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Every minute counts: study tracks how delays shape heart attack survival
- The heart rhythm threat hiding in heart attack wards
- Stick-On patch aims to catch dangerous heart decline sooner
- Heart pump timing put to the test in deadly heart attack shock
- AI on your phone: the future of heart attack detection in the field?
- Could intense workouts be safe after a rare heart attack? a trial puts HIIT to the test