Ambulance risk score could speed heart attack care
NCT ID NCT07252245
First seen Jun 25, 2026 · Last updated Sep 11, 2026 · Updated 3 times
Summary
This trial tests whether using a risk score and a rapid blood test in the ambulance can help decide where to take patients with chest pain. About 1,048 adults at intermediate or high risk for a heart attack will be randomly assigned to either this new triage method or usual care. The goal is to see if the new approach is faster, cheaper, and just as safe.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this approach could speed up diagnosis and treatment for heart attack patients, reduce hospital stays, and save healthcare costs.
- What could go wrong
- This is an early-stage trial testing a new triage process, not a treatment. It may not show clear benefits or could be difficult to implement widely.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 1,048 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2026
- Expected to finish
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Feb 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years * All out-of-hospital patients with chest pain or symptoms suggestive of ACS with an indication for transfer to the (cardiac) emergency department to evaluate and rule out ACS * Modified HEAR(T) score ≥ 4 * The patient has been informed of the nature of the study, agrees to its provisions and has provided written informed consent. Exclusion Criteria: * Electrocardiographic ST-segment elevation (STEMI) * Patients with confirmed myocardial infarction, PCI or CABG \<14 days prior to inclu-sion * Patients presenting an obvious non-cardiac cause for the chest complaints who need evaluation at an emergency department, e.g. trauma, pneumothorax, sepsis, etc. * Patients in comatose state, defined as an EMV \<8 * Patients with known cognitive impairment * Pregnancy * Patients presenting with cardiogenic shock, defined as: systolic blood pressure \<90mmHg and heart rate \>100 and peripheral oxygen saturation \<90% (without oxygen administration) * Patients presenting with syncope * Patients presenting with signs of heart failure * Patients presenting with second or third degree atrioventricular block * Patients without known supraventricular tachycardia i.e. unknown atrial fibrillation (known atrial fibrillation with adequate rate control can be included) * Patients with known end-stage renal disease (dialysis and/or GFR \< 30 ml/min) * Patients without a pre-hospital 12-lead ECG performed or available * Patients suspicious of aortic dissection or pulmonary embolism * Communication issues with patient/language barrier * Any significant medical or mental condition, which in the Investigator's opinion may interfere with the patient's optimal participation in the study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
3 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
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Locations
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RAV Brabant midden-west-noord: post Haps
RECRUITINGHaps, Netherlands
Contact Email: •••••@•••••
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Radboudumc Nijmegen, The Netherlands
RECRUITINGNijmegen, 6525 GA, Netherlands
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Veiligheidsregio Gelderland-Zuid
NOT_YET_RECRUITINGNijmegen, Netherlands
Contact Email: •••••@•••••
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