Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a quick, dye-free CT scan spot deadly lung clots?

NCT ID NCT07527117

Diagnosis Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 11, 2026 · Updated 2 times

Summary

This study explores whether a low-dose CT scan without contrast dye can accurately detect pulmonary embolism (blood clots in the lungs). Researchers will enroll 750 adults suspected of having a clot and add two very low-radiation CT scans to their standard dye-based scan. The goal is to see if the dye-free method can reliably rule out clots, potentially offering a safer option for patients who cannot receive contrast dye.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
low-dose non-contrast chest CT scan
What this could lead to
If successful, this could offer a safer, dye-free way to diagnose pulmonary embolism, especially for patients who cannot tolerate contrast dye.
What could go wrong
This is an early-stage diagnostic study, not a treatment trial. The new method may not be accurate enough to replace standard scans, and there is a small radiation risk from the extra CT images.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 750 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients undergoing CTPA for suspected aPE 2. Patients who provide written informed consent to participate 3. Adults patients \>/= 21 years of age 4. Mini Mental State Exam (MMSE) score of 18 or more. Exclusion Criteria: 1. Patients who decline informed consent 2. Patients with known chronic PE 3. Patients with known interstitial lung diseases 4. Patients who cannot raise their arms above their shoulders (arms can cause serious artifacts) 5. Women of child-bearing potential (\< 55 years) who test positive for pregnancy test 6. Patients \< 21 years of age (to avoid research radiation dose in young patients) 7. Patients with any EMR documented cognitive impairment or diseases such as dementia, recent head injury, psychiatric disorders, or other neurological diseases that impair decision-making. 8. Pregnant subjects 9. Women of child-bearing potential (21-55 years) who refuse to take a urine pregnancy test prior to their CT examination 10. Mini Mental State Exam (MMSE) score of less than 18.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Pulmonary embolism (diagnosis) are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

disease pulmonary embolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulmonary embolism (diagnosis) Pulmonary embolism acute

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Massachusetts General Hospital

    NOT_YET_RECRUITING

    Boston, Massachusetts, 02420, United States

  • Massachusetts General Hospital/Harvard Medical School

    RECRUITING

    Boston, Massachusetts, 02420, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.