Can a Clot-Removal procedure turn the tide in severe stroke?
NCT ID NCT07090941
First seen Aug 11, 2026 · Last updated Sep 04, 2026 · Updated 5 times
Summary
This trial is investigating whether adding a clot-removal procedure, called endovascular treatment, to standard medical care can improve outcomes for people who have had a severe stroke caused by a blockage in the basilar artery, a major vessel at the back of the brain. The study includes adults with a large area of brain damage who can be treated within 24 hours of symptoms starting. Participants are randomly assigned to receive either standard care alone or standard care plus the procedure, and their level of disability is measured after 90 days to see if the procedure helps them recover better.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Endovascular treatment (a procedure to remove the clot from the blocked artery in the brain)
- What this could lead to
- If successful, this could establish a new standard of care for a severe type of stroke, potentially improving recovery and reducing disability for many patients.
- What could go wrong
- The trial is still in progress, and the procedure carries risks such as bleeding or vessel damage. It may not prove more effective than standard care alone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 372 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2025
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 1\. Age ≥18 years. 2. Symptoms and signs consistent with basilar artery ischemia. 3. Basilar artery or vertebral artery occlusion confirmed by computed tomography angiography (CTA), magnetic resonance angiography (MRA), digital subtraction angiography (DSA); if vertebral artery occlusion is present, it must completely obstruct blood flow to the basilar artery. 4\. POST-NIHSS score ≥10 at randomization. 5. Time from symptom onset to randomization ≤24 hours (symptom onset defined as last known well time). 6\. pc-ASPECTS of 3-5 on CT/MRI (for patients aged \<80 years) or pc-ASPECTS of 3-7 (for patients aged ≥80 years). 7\. Willingness of the patient or legally authorized representative to comply with protocol requirements and data collection procedures, with documented informed consent. Exclusion Criteria: * 1\. Pre-stroke modified Rankin Scale (mRS) score \>2. 2. Factors in the target vessel that are expected to prevent completion of endovascular treatment. 3\. Concurrent anterior and posterior circulation strokes or multivessel occlusions. 4\. Significant mass effect with imaging or clinical signs of obstructive hydrocephalus or tonsillar herniation. 5\. Basilar artery occlusion confirmed as chronic by prior imaging or investigator judgment. 6\. Presence of untreated intracranial aneurysms, intracranial tumors (except small meningiomas), or intracranial vascular malformations. 7\. Intracranial hemorrhage within the past 6 months, including parenchymal brain hemorrhage, intraventricular hemorrhage, or subarachnoid hemorrhage. 8\. Presence of active bleeding, coagulation disorders, or uncorrectable bleeding tendencies. 9\. Severe heart, liver, or kidney dysfunction or other severe systemic late-stage diseases. 10\. Known allergy to iodine contrast agents or other treatment-related drugs. 11. Medically uncontrolled refractory hypertension (defined as persistent systolic blood pressure \>185 mmHg or diastolic blood pressure \>110 mmHg) (Note: Participants can be included if their blood pressure is controllable with medication and maintained at an acceptable level). 12\. Uncontrollable blood glucose \<2.8 mmol/L or \>22.2 mmol/L. 13. Pregnancy or breastfeeding. 14. Life expectancy \<6 months. 15. Participation in other clinical studies that may affect outcome assessment. 16. Investigator's judgment that the patient is unsuitable for participation in this study or may face significant risks (e.g., due to mental illness, cognitive, or emotional disorders preventing understanding and/or compliance with study procedures and/or follow-up).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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First Affiliated Hospital of Hainan Medical University
RECRUITINGHaikou, Hainan, 570100, China
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The First Affiliated Hospital of the University of Science and Technology of China
RECRUITINGHefei, Anhui, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a second intervention save the brain after a mild stroke?
- Clot-Removal procedure may offer hope for severe brain stem strokes
- Stroke treatment showdown: is removing the clot alone enough?
- Arm access showdown: which method is safer for artery procedures?
- New drug could extend window for treating deadly stroke
- New hope for Late-Stroke patients: clot removal may work even days later