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Scientists hunt for genetic clues in Virus-Linked cancers

NCT ID NCT03300830

Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 13 times

Summary

This study collects tissue and blood samples from adults with HIV, other immune disorders, or cancers thought to be caused by viruses. Researchers will compare genes in cancer tissue to normal tissue to find genetic changes that drive these cancers. The goal is to better understand the biology of these tumors, which could lead to improved prevention, detection, and treatment in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could reveal genetic clues that lead to better ways to prevent, detect, or treat cancers linked to viruses or immune problems.
What could go wrong
This is an observational tissue-collection study, not a treatment trial. It may not directly benefit participants, and results may take years to translate into clinical advances.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 280 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2017

Expected to finish

Jun 2037

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will be participants referred by HIV providers and those who provide primary care to the African immigrant community.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: Participants with one or more of the following: * HIV or other acquired immunodeficiency and cancer * Viral-associated cancer or cancer hypothesized to be caused by a virus * HIV-negative participants with cancer that commonly occurs in people with HIV --KSHV-associated malignancy or related diseases, such as Multicentric Castleman Disease (MCD) * A malignancy hypothesized to be caused by an endogenous retrovirus * Idiopathic Castleman disease Cancer diagnoses will be confirmed by the NCI Laboratory of Pathology (LP). A biopsy will be collected if sufficient archival tissue is not available. * Age \>=18 years. * ECOG performance status \<=2 (Karnofsky \>=60%) if biopsy to be performed is solely for the purposes of this protocol. Any ECOG performance status will be allowed if biopsy required for participant care or another NIH protocol that allows lower performance status or if enrollment on this protocol is only for the purposes of studying tissue that has already been collected. * Participants must have signed or be willing to sign an IRB-approved informed consent document that permits the use of the tumor and other samples for genomic-based molecular characterization projects. Telephone consent for use of archival tissue or tissue collected on another protocol or standard participant care will be permitted. * Co-enrollment on other HAMB, NCI, or NIH protocols is allowed EXCLUSION CRITERIA: * Inability to provide informed consent. * Pregnancy: Pregnant women will not be allowed to participate in this study because there is not a potential benefit.

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Conditions

The condition(s) this trial relates to.

AIDS Castleman disease HIV infectious disease HIV-associated cancer human herpesvirus 8-related tumor idiopathic multicentric Castleman disease inborn error of immunity Kaposi's sarcoma multicentric Castleman disease virus associated tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Castleman's disease Human immunodeficiency virus Kaposi's sarcoma Viral-associated cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.