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One-Size-Fits-All blood thinners challenged: new study tailors treatment to each patient

NCT ID NCT06581965

First seen Sep 30, 2025 · Last updated Jun 17, 2026 · Updated 37 times

Summary

This study tests whether giving blood thinners based on each person's risk level after hip or knee replacement works better than the standard one-dose-for-all approach. About 10,000 adults having elective hip or knee replacement will be assigned to either standard care or a personalized plan: low-risk patients get a shorter course to reduce bleeding, while high-risk patients get a stronger, longer course to prevent dangerous clots. The goal is to find the right balance that lowers both clots and bleeding complications.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Alrijne

    RECRUITING

    Leiderdorp, South Holland, 2353 GA, Netherlands

  • Anna Ziekenhuis

    RECRUITING

    Geldrop, North Brabant, 5564EH, Netherlands

  • Bergman Clinics

    RECRUITING

    Naarden, North Holland, 1411DE, Netherlands

  • Bravis ziekenhuis

    NOT_YET_RECRUITING

    Roosendaal, North Brabant, 4708 AE, Netherlands

  • Elisabeth-TweeSteden Ziekenhuis

    RECRUITING

    Tilburg, North Brabant, 5022GC, Netherlands

  • Gelre Ziekenhuizen

    RECRUITING

    Apeldoorn, Gelderland, 7334 DZ, Netherlands

  • Isala ziekenhuis

    RECRUITING

    Zwolle, Overijssel, 8025AB, Netherlands

  • OLVG

    RECRUITING

    Amsterdam, North Holland, 1091AC, Netherlands

  • Reinier Haga Orthopedisch Centrum

    RECRUITING

    Zoetermeer, South Holland, 2725NA, Netherlands

  • Zuyderland

    RECRUITING

    Geleen, Limburg, 6162 BG, Netherlands

Conditions

The condition(s) this trial relates to.

pulmonary embolism venous thromboembolism Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.