Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

One size Doesn't fit all: new trial tests tailored blood thinners for joint replacement patients

NCT ID NCT06581965

Disease control Sponsor: Leiden University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 09, 2026 · Updated 3 times

Summary

After hip or knee replacement, all patients currently get the same dose of blood thinners to prevent clots, but some still get clots while others bleed. This trial will test whether giving a shorter course to low-risk patients and a stronger, longer course to high-risk patients can reduce both clots and bleeding. Over 10,000 adults scheduled for joint replacement will be randomly assigned to either standard or personalized treatment and followed for three months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
blood thinners (LMWH or DOACs)
What this could lead to
If successful, this could show that customizing blood thinner treatment after joint replacement lowers the risk of both dangerous clots and bleeding complications.
What could go wrong
This is a large Phase 4 trial, but individualizing treatment may still fail to improve outcomes or could increase risks in some patients. Results may not apply to all hospitals or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 10,078 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Feb 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Scheduled to undergo an elective total hip arthroplasty or total knee arthroplasty * Aged 18 years or older Exclusion Criteria: * Primary arthroplasty for fractures * Revision surgery * Hemiarthroplasty * Pregnancy * Current use of therapeutic anticoagulant therapy of any type (e.g., LMWH, DOAC, vitamin K antagonist) * A contraindication for either study drug * Insufficient knowledge of the Dutch language * Insufficient mental or physical ability to fulfil trial requirements * Active malignancy (i.e. cancer diagnosis within six months before surgery (excluding basal-cell or squamous-cell carcinoma of the skin), recently recurrent or progressive cancer or any cancer that required anti-cancer treatment within six months before surgery) * Patients using thrombocyte aggregation inhibitors that cannot be temporarily discontinued at the discretion of their treating physician

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Deep vein thrombosis are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

pulmonary embolism venous thromboembolism Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Deep vein thrombosis Pulmonary embolism Venous thromboembolism Venous thromboses

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    13 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Alrijne

    RECRUITING

    Leiderdorp, South Holland, 2353 GA, Netherlands

  • Anna Ziekenhuis

    RECRUITING

    Geldrop, North Brabant, 5564EH, Netherlands

  • Bergman Clinics

    RECRUITING

    Naarden, North Holland, 1411DE, Netherlands

  • Elisabeth-TweeSteden Ziekenhuis

    RECRUITING

    Tilburg, North Brabant, 5022GC, Netherlands

  • Gelre Ziekenhuizen

    RECRUITING

    Apeldoorn, Gelderland, 7334 DZ, Netherlands

  • Groene Hart Ziekenhuis

    RECRUITING

    Gouda, Netherlands

  • IJsselland Ziekenhuis

    NOT_YET_RECRUITING

    Capelle aan den IJssel, Netherlands

  • Isala ziekenhuis

    RECRUITING

    Zwolle, Overijssel, 8025AB, Netherlands

  • OLVG

    RECRUITING

    Amsterdam, North Holland, 1091AC, Netherlands

  • Reinier Haga Orthopedisch Centrum

    RECRUITING

    Zoetermeer, South Holland, 2725NA, Netherlands

  • St. Antonius Ziekenhuis

    RECRUITING

    Utrecht, Utrecht, Netherlands

  • ZorgSaam

    RECRUITING

    Terneuzen, Zeeland, Netherlands

  • Zuyderland

    RECRUITING

    Geleen, Limburg, 6162 BG, Netherlands

More trials for these conditions

Other studies related to the condition(s) this trial covers.