PULMONARY EMBOLISM

This study compares a new device called FlowTriever to standard treatment for people with a life-threatening blood clot in the lungs (high-risk pulmonary embolism). About 200 adults will be randomly assigned to get either the device or usual care. The goal is to see if the device…

This study tests a pharmacy-led program to help low-income patients with chronic conditions like diabetes and heart disease take their medications after leaving the hospital. The program provides free medications, bedside delivery, and health coaches to help with follow-up care. …

This study is testing two medical devices (Symphony and Prodigy) that remove blood clots from arteries, veins, or the lungs. About 750 adults will be enrolled to see if the devices are safe and work well in the short and long term. The goal is to improve blood flow and prevent se…

This study tests whether giving blood thinners based on each person's risk level after hip or knee replacement works better than the standard one-size-fits-all approach. About 10,000 adults having elective hip or knee replacement will be assigned to either standard treatment or a…

This study compares two treatments for people with a serious but stable blood clot in the lungs (submassive pulmonary embolism). Half of the 500 participants will receive standard blood thinners alone, while the other half will also get a catheter procedure to remove the clot. Th…

This study compares using a device called FlowTriever plus blood thinners versus blood thinners alone in 1,200 people with intermediate-risk pulmonary embolism (a blood clot in the lungs). The goal is to see if the device reduces death, prevents worsening, and improves breathing.…

This study follows 82 people who receive a vena cava filter to catch blood clots and prevent them from reaching the lungs. Researchers will check for complications like filter movement or breakage over 5 years. The goal is to confirm the device works safely for long-term use.

This study tests a device called AlphaVac that is used to remove blood clots from the lungs in people with acute pulmonary embolism (a sudden blockage in the lung artery). About 256 adults with confirmed clots and signs of heart strain will be enrolled. The goal is to see if the …

This study is testing a device called the Indigo Aspiration System to remove blood clots from the lungs in people with pulmonary embolism (PE). The goal is to see if it is safe and works well over the long term. About 1500 adults with acute PE will be enrolled. The study will tra…

This study compares two blood thinners—rivaroxaban (a pill) and low-molecular-weight heparin (a daily injection)—in people with leg injuries that require a cast or brace for at least two weeks. The goal is to see if the pill is as good as or better than the injection at preventin…

This study tests a single-dose medicine (staphylokinase) to see if it can prevent death, heart failure, or repeat blood clots in people with a serious type of pulmonary embolism. About 486 adults with intermediate high-risk clots will receive either the drug or a placebo. The goa…

This study tests a new device called the Laguna Thrombectomy System to remove blood clots from the lungs in people with pulmonary embolism. About 107 adults with a recent clot and stable blood pressure will receive the procedure. The goal is to see if the device safely reduces cl…

This study aims to see if a new tool called Adjust-Unlikely can safely reduce the number of unnecessary CT scans for blood clots in the lungs (pulmonary embolism) in emergency department patients. Current testing often leads to scans that expose patients to radiation, cost time a…

This study tests a new portable chest X-ray machine that takes moving images (15 frames per second) right at the bedside in the ICU. Researchers want to see if it gives doctors better information about lung and diaphragm function compared to standard X-rays. About 230 adults with…

This study looks at two checklists (PERC and YEARS) that doctors can use to decide if a patient with a possible lung clot needs a CT scan. Researchers will review records of 500 adults who came to the emergency room with symptoms and had both a blood test and a chest scan. The go…

This study looks at 200 people with high-blood-pressure-related brain bleeding to find the best time to start blood thinners (heparin) to prevent dangerous clots in the legs or lungs. Participants get heparin either within 2 days (but not before 12 hours) or starting on day 3 aft…

This study tests if a 6-week outpatient pulmonary rehabilitation program can improve breathing and walking ability in people with post-PE syndrome, a condition where symptoms like shortness of breath persist after a pulmonary embolism. About 48 adults will be randomly assigned to…

This study is a registry that will collect information from about 1,000 adults who have already been treated with an Inari Medical device for a pulmonary embolism (a blood clot in the lung). The goal is to track how safe the devices are by recording any serious side effects relat…

This study looks at whether a one-minute chair lift test can help doctors predict how well patients with a non-severe pulmonary embolism (a blood clot in the lungs) will recover. Researchers will compare the test results with standard risk scores and heart markers. The goal is to…

This study is for cancer patients who have a blood clot and are taking blood thinners. These medicines can cause dangerous bleeding. Researchers want to see if a special blood test (thrombin generation assay) can predict who is at higher risk of bleeding. The study will follow 21…

This study observes 1,300 critically ill ICU patients to see if measuring anti-factor Xa activity (a blood thinner level) is linked to dangerous blood clots. Researchers want to understand how well current blood thinner dosing works and whether it affects bleeding, survival, and …

This study tracks 220 adults with acute pulmonary embolism who receive either clot-busting drugs or a catheter-based procedure. Researchers will compare rates of severe bleeding and death within 30 days. The goal is to understand which treatment is safer and more effective in rea…

This study looks at how fast patients in the intensive care unit with a serious lung clot (pulmonary embolism) receive effective blood-thinning medication. Researchers will review data from 100 adults treated between 2014 and 2023 to see how quickly their blood reached a therapeu…

This study tests whether using ultrasound to check for deep-vein thrombosis (DVT) in critically ill patients can help prevent pulmonary embolism (a dangerous clot in the lungs) and reduce deaths within 90 days. About 1,800 adult ICU patients expected to stay more than 2 days will…

This study tests whether a hospital-wide quality improvement program can increase the use of blood clot prevention methods (like blood thinners or compression devices) in hospitalized patients. About 5,800 adults across multiple hospitals in China will take part. The goal is to s…

This study uses artificial intelligence to group patients who have had a pulmonary embolism (a blood clot in the lung) based on their medical information at diagnosis. The goal is to see if these groups have different outcomes six months later, such as recurrence or long-term com…

This study looks at how well a treatment called ultrasound-assisted catheter-directed thrombolysis works for people with serious blood clots in the lungs (intermediate-high-risk pulmonary embolism). Researchers will track 180 participants for 6 months to see how many develop high…