Could a cholesterol drug stop blood clots from coming back?

NCT ID NCT04319627

Recruiting now Disease control Sponsor: Ottawa Hospital Research Institute Source: ClinicalTrials.gov ↗

First seen Jan 03, 2026 · Last updated Jun 23, 2026 · Updated 30 times

Summary

This study is testing whether adding rosuvastatin (a common cholesterol-lowering drug) to standard blood thinner treatment can lower the risk of another blood clot in people who have recently had a deep vein thrombosis or pulmonary embolism. About 2,700 participants will receive either rosuvastatin or a placebo pill alongside their usual care. The goal is to see if the statin reduces recurrent clots and helps prevent long-term vein damage.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Phone: •••-•••-•••• Email: •••••@•••••
Contact

Email: •••••@•••••

Locations

APHP Hôpital Louis Mourier
RECRUITING

Colombes, France

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Aberdeen Royal Infirmary
NOT_YET_RECRUITING

Aberdeen, United Kingdom

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Brest University Hospital Centre
RECRUITING

Brest, France

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CHI Toulon - La Seyne sur Mer - Hôpital Sainte Musse
RECRUITING

Toulon, France

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CHU d'Angers - Service d'accueil et traitement des Urgences
RECRUITING

Angers, France

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CHU de Clermont-Ferrand, Hôpital Gabriel Montpied
RECRUITING

Clermont-Ferrand, France

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CHU de Dijon - Service d'imagerie diagnostique et thérapeutique
RECRUITING

Dijon, France

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CHU de Quebec-Université Laval
RECRUITING

Québec, Quebec, G1V 4G2, Canada

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CIUSSS de-l'Ouest-de-l'Ile-de-Montreal -St. Mary's Hospital Center
RECRUITING

Montreal, Quebec, H9R 2Y2, Canada

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Centre Hospitalier Universitaire De Saint Etienne
RECRUITING

Saint-Etienne, France

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Foothills Medical Centre
RECRUITING

Calgary, Alberta, T2N 2T9, Canada

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GH La Rochelle - Ré-Aunis - Service de Médecine vasculaire
RECRUITING

La Rochelle, France

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Glasgow Royal Infirmary
NOT_YET_RECRUITING

Glasgow, United Kingdom

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Hamilton General Hospital
RECRUITING

Hamilton, Ontario, L8L 2X2, Canada

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Hôpital Montfort
WITHDRAWN

Ottawa, Ontario, K1K 0T2, Canada
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada

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Juravinski Hospital
WITHDRAWN

Hamilton, Ontario, L8V 1C3, Canada
King's College Hospital NHS Foundation Trust
NOT_YET_RECRUITING

London, United Kingdom

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Mater Misericordiae University Hospital
NOT_YET_RECRUITING

Dublin, Ireland

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McGill Univeristy Health Centre
RECRUITING

Montreal, Quebec, H4A 3J1, Canada

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Niagara Health - St. Catharines Site
RECRUITING

St. Catharines, Ontario, L2S 0A9, Canada

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Ostfold Hopsital
RECRUITING

Sarpsborg, Norway

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Oxford University Hospitals NHS Foundation Trust
NOT_YET_RECRUITING

Oxford, United Kingdom

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Queen Elizabeth Hospital
NOT_YET_RECRUITING

Birmingham, United Kingdom

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Queen Elizabeth II Hospital
WITHDRAWN

Halifax, Nova Scotia, B3H 2Y9, Canada
St. Joseph's Healthcare
RECRUITING

Hamilton, Ontario, L8N 4A6, Canada

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Sunnybrook Hospital
NOT_YET_RECRUITING

Toronto, Ontario, M4N 3M5, Canada

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The Ottawa Hospital
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada

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Contact Email: •••••@•••••
University Health Network
RECRUITING

Toronto, Ontario, M5G 2C4, Canada

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University Hospital of Wales
NOT_YET_RECRUITING

Cardiff, United Kingdom

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University of Insubria
NOT_YET_RECRUITING

Varese, Italy

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What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Rosuvastatin (a cholesterol-lowering statin drug)

What this could lead to

If it works, this could show that adding a common statin to standard blood thinners helps prevent future blood clots and reduces long-term vein damage.

What could go wrong

This is a large phase 3 trial, but statins are not yet proven for this use. The benefit may be small or absent, and statins can cause muscle pain or rare liver issues.

Conditions

The condition(s) this trial relates to.

Postthrombotic Syndrome thrombotic disease venous thromboembolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLOOD CLOT POST THROMBOTIC SYNDROME POST THROMBOTIC SYNDROME VENOUS THROMBOEMBOLISM