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New shot could replace aspirin to stop clots after knee surgery

NCT ID NCT07213778

Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 15, 2026 · Updated 9 times

Summary

This study tests an experimental drug called REGN7508 (cenvacibart) against aspirin to prevent blood clots in 2000 adults having knee replacement surgery. The drug targets a clotting factor to reduce clot risk. Researchers will compare how many people develop clots or die from clot-related causes in each group.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
REGN7508 (cenvacibart), a factor XI monoclonal antibody
What this could lead to
If it works, this could offer a new way to prevent dangerous blood clots after knee replacement surgery with potentially fewer bleeding risks than current options.
What could go wrong
This is a large phase 3 trial, but the drug is still experimental. It may not prove safer or more effective than aspirin, and unexpected side effects or bleeding risks remain possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 2,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: 1. Is undergoing a primary elective unilateral TKA 2. Is in good health based on laboratory safety testing as described in the protocol Key Exclusion Criteria: 1. Any condition that, as assessed by the investigator, may confound the results of the study or pose an additional risk to the participant by study participation 2. History of bleeding in the 6 months prior to randomization requiring hospitalization or transfusion; history of intracranial or intraocular bleeding, excessive operative or post-operative bleeding, and traumatic spinal or epidural anesthesia; history of bleeding diathesis (eg, hemophilia A or B, von Willebrand's Factor deficiency) 3. History of thromboembolic disease or thrombophilia 4. History of platelet dysfunction 5. Has received or plans to receive preoperative enoxaparin on the day prior to TKA surgery Note: Other protocol-defined Inclusion/ Exclusion criteria apply

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Conditions

The condition(s) this trial relates to.

pulmonary embolism Venous Thrombosis venous thromboembolism prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Symptomatic venous thromboembolism (VTE)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    34 sites in 4 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Boston Medical Center

    RECRUITING

    Boston, Massachusetts, 02118, United States

  • Carilion Clinic

    RECRUITING

    Roanoke, Virginia, 24015, United States

  • Coastal Vascular Institute, PA

    RECRUITING

    Wilmington, North Carolina, 28401, United States

  • Duke University Health System (Duke Health), Duke University Hospital

    RECRUITING

    Durham, North Carolina, 27710, United States

  • Eisenhower Medical Center

    RECRUITING

    Rancho Mirage, California, 92270, United States

  • Endeavor Clinical Trials

    WITHDRAWN

    San Antonio, Texas, 78240, United States

  • Endeavor Health

    RECRUITING

    Skokie, Illinois, 60076, United States

  • Eximia Equihealth Research-Raleigh. LLC

    RECRUITING

    Raleigh, North Carolina, 27612, United States

  • Flourish Research - San Antonio (Formerly Clinical Trials of Texas)

    RECRUITING

    San Antonio, Texas, 78229, United States

  • HD Research - Memorial Hermann Village

    COMPLETED

    Houston, Texas, 77043, United States

  • Henry Dunant Hospital Center

    RECRUITING

    Athens, Attica, 11526, Greece

  • Holy Name Medical Center

    RECRUITING

    Teaneck, New Jersey, 07666, United States

  • Horizon Clinical Research

    RECRUITING

    La Mesa, California, 91942, United States

  • Hospital Pakar Universiti Sains Malaysia

    RECRUITING

    Kota Bharu, Kelantan, 16150, Malaysia

  • Hospital Queen Elizabeth II

    RECRUITING

    Kota Kinabalu, Sabah, 88300, Malaysia

  • Hospital Tengku Ampuan Afzan (HTTA)

    RECRUITING

    Kuantan, Pahang, 25100, Malaysia

  • Larkin Community Hospital South Miami

    RECRUITING

    South Miami, Florida, 33143, United States

  • Medical Research of Westchester - MPLUS Research Network

    RECRUITING

    Miami, Florida, 33165, United States

  • NextStage Clinical Research, All American Orthopedics and Sports Medicine

    RECRUITING

    Houston, Texas, 77058, United States

  • NextStage Clinical Research, St. Francis Medical Park

    RECRUITING

    Wichita, Kansas, 67214, United States

  • Ohio Clinical Trials

    RECRUITING

    Columbus, Ohio, 43212, United States

  • PMSI Emergency Medicine Institute

    RECRUITING

    Chisinau, MD-2004, Moldova

  • Phoenix Clinical Research

    RECRUITING

    Tamarac, Florida, 33321, United States

  • Sinai Hospital of Baltimore, Inc.

    RECRUITING

    Baltimore, Maryland, 21215, United States

  • Sky Ridge Medical Center

    RECRUITING

    Lone Tree, Colorado, 80124, United States

  • South Florida Joint Replacement Center

    RECRUITING

    Deerfield Beach, Florida, 33064, United States

  • Spokane Joint Replacement Center

    RECRUITING

    Spokane, Washington, 99218, United States

  • Sultan Abdul Halim Hospital

    RECRUITING

    Sungai Petani, Kedah, 08000, Malaysia

  • The Ohio State University Wexner Medical Center

    RECRUITING

    Columbus, Ohio, 43210, United States

  • The Orthopaedic Research Foundation, Inc.

    RECRUITING

    Indianapolis, Indiana, 46278, United States

  • The Vein and Vascular Center at Raleigh Radiology

    RECRUITING

    Raleigh, North Carolina, 27612, United States

  • Tufts Medical Center

    RECRUITING

    Boston, Massachusetts, 02111, United States

  • University of Cincinnati

    RECRUITING

    Cincinnati, Ohio, 45267, United States

  • University of Pittsburgh

    RECRUITING

    Pittsburgh, Pennsylvania, 15213-3108, United States

  • University of Rochester Medical Center

    RECRUITING

    Rochester, New York, 14623-5863, United States

  • Velocity Clinical Research, Annapolis

    RECRUITING

    Annapolis, Maryland, 21401, United States