VASCULAR DISEASES

This study aims to learn about the long-term safety and effectiveness of the drug ralinepag for adults with pulmonary arterial hypertension (PAH), a serious lung and heart condition. It is an extension study for about 1,000 people who have already taken ralinepag in a previous cl…

This program provides special access to an experimental, lab-grown blood vessel for patients with severe vascular disease or who need dialysis access and have no other treatment options. It is not a standard clinical trial but a case-by-case request process for individual patient…

This study is testing a medical device procedure called renal denervation for people whose high blood pressure remains uncontrolled despite medications. The procedure uses a catheter to deliver energy to nerves around the kidney arteries, aiming to lower blood pressure long-term.…

This study aimed to see if a 4-day low-calorie, low-protein 'shake' diet before leg bypass surgery could help prevent vein grafts from failing. Researchers wanted to test if patients could follow this diet at home and if it boosted the body's natural production of hydrogen sulfid…

This study is comparing two different types of biodegradable heart stents (SUPRAFLEX Cruz vs. SYNERGY) in patients with severe blockages in all three major heart arteries. About 1,550 participants will have the stents placed and be followed for at least a year to see which stent …

This study is testing a new medical device called the Aventus Thrombectomy System. It is designed to physically remove dangerous blood clots from the lungs of patients with a sudden, severe pulmonary embolism. The trial will enroll 130 adults to see if the procedure is safe and e…

This study is testing whether an inhaled drug called mosliciguat is safe and effective for people who have high blood pressure in their lungs (pulmonary hypertension) caused by underlying lung scarring (interstitial lung disease). About 135 participants will be randomly assigned …

This study was withdrawn before enrolling any participants. It aimed to understand if PCSK9 inhibitor drugs, which lower cholesterol, also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation i…

This study aimed to create a detailed 12-month profile of patients admitted for vascular surgery at a specific hospital. Researchers planned to review patient records to understand admission patterns, treatments, and hospital stays. The goal was to use this information to improve…