VASCULAR DISEASES

This study tests a new device called the Aventus Thrombectomy System to safely remove blood clots from the lungs in people with acute pulmonary embolism. About 130 adults aged 18 to 80 with recent clot symptoms will be treated. The goal is to see if the device improves heart func…

This program offers a lab-grown blood vessel (ATEV) to people with serious vascular disease or kidney failure on dialysis who have no other treatment options and cannot join a clinical study. The vessel is designed to replace or repair damaged blood vessels. The goal is to provid…

This study tests an inhaled medicine called mosliciguat for people with high blood pressure in the lungs caused by scarring lung disease. About 135 adults will receive either the drug or a placebo for 16 weeks. The goal is to see if the drug improves blood flow in the lungs and w…

This study looks at the long-term safety of a drug called ralinepag for people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who were in earlier ralinepag studies can join. The goal is to see if the drug is …

This study compares two drug-coated stents (SUPRAFLEX Cruz and SYNERGY) in about 1,550 people with severe blockages in three heart arteries. Participants receive modern heart care including imaging and medications. The goal is to see which stent is safer and more effective at pre…

This study tests whether a lower blood pressure target than the current standard can reduce major heart problems and strokes in people who have already had a stroke. About 4,300 participants will be randomly assigned to either intensive or standard blood pressure control and foll…

This study looks at a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys, to help lower blood pressure in people whose hypertension is not controlled by medication. About 1,900 adults with high blood pressure are taking part. The goal i…

This study tests a device that uses ultrasound to calm overactive nerves in the kidneys, which can help lower blood pressure. About 282 adults with high blood pressure took part. The goal was to see if the device works better than a fake procedure (sham) to safely reduce blood pr…

This study tests a device that uses ultrasound to calm overactive kidney nerves, which can help lower blood pressure. About 154 adults with high blood pressure who are already taking two medications will receive either the ultrasound treatment or a fake procedure. The goal is to …

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor can also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. However, the study was withdrawn before enr…

This study aimed to see if virtual clinic visits (using tablets) work as well as in-person visits for people with vascular diseases. Doctors would classify patients' need for treatment after both types of visits to check if the results matched. The study was withdrawn before any …

This study aimed to create a 12-month profile of patients admitted for vascular surgery at an Irish hospital. Researchers planned to measure frailty and other health factors to find ways to improve care and shorten hospital stays. However, the study was withdrawn before enrolling…

This study aimed to see if patients could follow a short-term protein-calorie restriction diet for 4 days before elective vascular surgery. Researchers planned to measure diet compliance and changes in blood markers related to stress and healing. However, the study was withdrawn …