CARDIOVASCULAR DISEASES

This study tests a face-to-face program called Transition to Cardiac Rehabilitation (T2CR) for Veterans with heart disease who also have other health problems or frailty. The goal is to help them build skills and motivation to successfully participate in home-based cardiac rehab.…

This study looks at how healthy diets with different plant oils, especially cottonseed oil, affect heart and metabolic health. About 52 adults with higher cholesterol and body weight will eat controlled diets for 4 weeks each. Researchers will measure cholesterol and other blood …

This study tests a new device called SoniCracker that uses sound waves to break up hard calcium deposits in heart arteries. It is for 40 adults with calcified coronary arteries who are already scheduled for a stent procedure. The goal is to see if the device helps place stents mo…

This study is a registry that will follow about 960 people with coronary artery disease who are treated with the SELUTION sirolimus-eluting balloon, a device that delivers medication to open blocked heart arteries. The goal is to see how safe and effective the balloon is in real-…

This study looks at how to help churches in Latino communities run programs that get women more physically active. About 560 Latina women aged 18-65 who are not very active will take part. The goal is to see if adding extra support for church leaders and health workers helps wome…

This study tests whether a new drug, vicadrostat, works differently than the older drug spironolactone when both are taken with empagliflozin. About 100 adults with chronic kidney disease and heart disease or heart failure will take one of the two combinations for 26 weeks. Resea…

This study looks at how well a procedure called ultrasound renal denervation works over time to lower blood pressure in people 65 and older whose blood pressure is not well controlled with medication. Researchers will review medical records from 1,000 Medicare patients to see if …

This study looks at whether a procedure called renal denervation (RDN) helps lower blood pressure over two years in Medicare patients with uncontrolled hypertension. Researchers will compare patients who received RDN plus standard care to those who received standard care alone, u…

This study tests a non-invasive treatment called remote ischemic conditioning (RIC) for people recovering from a serious brain bleed (aneurysmal subarachnoid hemorrhage) after surgery. RIC uses a blood pressure cuff on the arm to create brief, harmless blood flow interruptions, w…

This study tests a special balloon coated with a drug (sirolimus) to open up small blood vessels in the heart that are narrowed by coronary artery disease. About 1,600 adults with chest pain or silent ischemia will be randomly assigned to receive this balloon or standard treatmen…

This study looks at whether empagliflozin, a drug originally for diabetes, can improve heart function in 80 older adults with high blood pressure and obesity who are at risk for heart failure. Participants will take either the drug or a placebo daily for 9 months. The goal is to …

This study tests whether a mechanical heart pump (HeartMate 3) can help people with advanced heart failure live longer and avoid serious complications like stroke or the need for a heart transplant. About 850 participants will either receive the pump or continue with standard med…

This study tests a program called CVD-FIT for 200 African American adults who have trouble affording enough food. Participants get monthly cash, weekly rewards for buying healthy groceries, and phone coaching on heart health. The goal is to see if these supports can lower their 1…

This study tests a new treatment that uses focused ultrasound to modify fat around the kidney, aiming to lower blood pressure in people with essential hypertension. About 30 adults whose blood pressure remains high despite medication will be randomly assigned to receive the ultra…

This study is for adults with high blood pressure that stays high even with lifestyle changes and medication. It tests a device called the Paradise System, which uses ultrasound to calm overactive kidney nerves. Researchers will check if the treatment safely lowers blood pressure…

This study tests different support programs to help heart patients maintain healthy habits after cardiac rehabilitation. Researchers will enroll 400 adults who are finishing rehab and belong to groups often underrepresented in research, such as women, racial minorities, or those …

This study tests whether taking low-dose aspirin for six months after childbirth can help women who had preeclampsia recover their blood vessel health and lower their blood pressure. About 60 new mothers will be randomly assigned to receive aspirin or a placebo. The goal is to se…

This study is testing a new replacement valve for the tricuspid heart valve in people with severe leakage (regurgitation) who are at high risk for open-heart surgery. The valve is delivered through a tube in a blood vessel, avoiding major surgery. Researchers will check if the va…

This study looks at whether having a heart doctor check patients during a COPD flare-up can find and treat hidden heart problems. 150 adults hospitalized for COPD will be split into two groups: one gets standard lung care, the other also sees a heart doctor. Both groups are follo…

This study tests if a device called the Gemini System can safely lower blood pressure by disrupting certain nerves in the kidney and liver. It includes 175 adults with uncontrolled high blood pressure, with or without other health risks like heart or kidney disease. The main goal…

This study tests whether a church-based program led by community health workers can help Black adults in New Orleans lower their risk of heart disease, high blood pressure, diabetes, and high cholesterol. About 806 adults aged 40 and older with at least three heart disease risk f…

This study tests whether remote exercise programs (using a smartphone app or live video classes) can help adults over 45 who are at risk for heart disease become more active. Thirty participants will be randomly assigned to one of four exercise groups for 12 weeks. The goal is to…

This study looks at whether a special clinic focused on heart health and weight can help obese adults with heart disease lose weight and improve their health. About 60 participants will be followed for 12 months to measure weight loss, body mass index, and belly fat. The goal is …

This study tests a digital app called VIRTUES that helps people with heart conditions manage their health from home. The app provides personalized recommendations for medications, diet, exercise, and more. Researchers will enroll 2,000 patients to see if the app is easy to use an…

This study tests whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as two blood thinners (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 p…

This study looks at whether adding stair climbing to daily routines can lower blood pressure more than brisk walking alone. About 450 adults with high blood pressure, overweight, and a sedentary lifestyle will be split into three groups: stair walking plus brisk walking, brisk wa…

This study tests whether getting a flu vaccine outside of flu season can reduce inflammation in the arteries of people who recently had a heart attack. About 90 participants will receive either the flu vaccine or a placebo, and doctors will use special CT scans to measure artery …

This study is testing whether a combination of green propolis extract and royal jelly can lower inflammation and oxidative stress in people with chronic kidney disease or high blood pressure. About 153 participants will take the supplement or a placebo for two months. Researchers…

This study is checking how well two new stents (Synergy XD and Synergy Megatron) work in everyday medical practice for people with coronary artery disease. About 2000 adults getting these stents will be followed to see if they have fewer heart attacks, need repeat procedures, or …

This study tests whether nattokinase, an enzyme from fermented soy (natto), can reduce inflammation and improve heart health markers in people with high cholesterol. Researchers will give 48 adults either nattokinase or a placebo for two months and measure changes in blood marker…

This study tests whether a special screening and a tailored exercise program (RYMA) can reduce falls, fractures, and heart risks in people aged 65+ with type 1 or type 2 diabetes. About 490 participants will be assigned to either the exercise program or usual care and followed fo…

This study tests a school-based program called Strong Teens for Healthy Schools that empowers middle school students to improve their physical activity and healthy eating. About 500 students from diverse backgrounds will participate to see if the program reduces metabolic syndrom…

This study is testing a mobile health program called HeartSteps to help people with heart disease become more physically active. Sixty adults who are finishing or have recently finished cardiac rehab will wear a Fitbit and use the app for 3 months. The goal is to see if the app h…

This early study tests a new device called the Topaz system, which replaces the tricuspid heart valve without open-heart surgery. It is for 15 adults with severe tricuspid regurgitation (leaky valve) who are at high risk for surgery. The goal is to see if the device is safe and c…

This study tests whether adding digital coaching—including a private social media group and video sessions—to home-based cardiac rehab helps veterans with heart disease complete more rehab sessions and improve their fitness, activity levels, and mental well-being. About 150 veter…

This study tests a 24-week program called Black Impact to improve heart health and reduce stress in Black men. About 340 Black men with below-ideal heart health will either join the program right away or be placed on a waitlist. The program includes weekly exercise, health educat…

This study tests whether a digital heart health program (app and online sessions) added to usual care can lower cholesterol and reduce heart attacks, strokes, and other major heart events over 7 years. About 1,100 adults with heart disease or high risk factors who are already on …

This study is testing whether a special wearable device, guided by artificial intelligence, can help adults with chronic heart failure avoid emergency visits and hospital stays. About 205 participants will either wear the device for six months or receive standard care. The goal i…

This study tests whether taking atorvastatin (a statin) can help healthy adults aged 75 and older avoid dementia, disability, and heart problems. About 20,000 participants will be randomly assigned to take either the drug or a placebo pill for several years. The goal is to see if…

This study looks at whether omega-3 supplements can reduce inflammation and improve heart health in 200 healthy adults. Researchers want to see if a person's genetic makeup (specifically the FADS gene) and ancestry (African American vs. European American) affect how well omega-3s…

This study tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online group meetings, a smartphone app for tracking blood pressure and weight, and health education. Researchers want to see if it lowers blood pressure and helps…

This study looks at whether whole or nonfat milk is better for body fat, heart health, and diet in 200 children aged 9-12 who have a higher BMI. Participants drink either whole or nonfat milk for one year while researchers measure changes in fat mass, lean mass, and other health …

This study tests whether simple home-based strategies and wearable devices can help reduce the negative health impact of evening screen time. Researchers will enroll 30 adults who spend at least 3 hours per day on recreational screens and have risk factors for heart disease, diab…

This study tests whether a 3-month community cooking class focused on the Mediterranean diet can improve heart health and mental well-being in racially diverse seniors aged 55 and older. Participants will learn to cook healthy meals and have their blood pressure, blood sugar, and…

This study tests a program called Inspire HER for Black women aged 30-79 with heart, kidney, and metabolic health issues. The program offers health education, physical activity, and social support to help lower heart disease risk. Researchers will see if the program is practical …

This study tests whether an enhanced community health worker program helps 500 Philadelphia residents aged 35-75 better manage heart disease risks and meet their social needs. Participants will either join group sessions plus one-on-one consultations or receive standard services.…

This study tests a new inhaled drug, mosliciguat, added to an existing treatment (treprostinil) for people with high blood pressure in the lungs caused by scarring lung disease. About 20 adults will take part to see if the combination is safe and tolerable. The goal is to manage …

This study is watching 2000 people who get a special heart stent (VIVO ISAR) and take blood thinners for only 3 months or less. The goal is to see if this short blood thinner plan is safe and works well. It is for people with clogged heart arteries getting a stent to keep them op…

This study tests whether adding vicadrostat to the standard drug empagliflozin can lower the chance of heart problems or death in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo plus empa…

This study tests a new heart pump called BrioVAD for people with severe heart failure that doesn't get better with other treatments. The pump uses magnetic levitation to help the heart pump blood. About 780 adults will get either the new pump or an existing one to see if the new …

This study compares two imaging methods for guiding treatment of hardened coronary arteries. About 700 adults with heart disease will either receive CT-guided or standard ultrasound-guided care during stent placement. The goal is to see if the CT approach improves stent expansion…

This study looks at whether taking blood pressure medication in the morning or evening can help restore the natural nighttime drop in blood pressure in people with obesity. Obese individuals often have high nighttime blood pressure, which raises their risk for heart problems. Res…

This study is testing whether getting healthy, DASH-diet groceries delivered to your home, along with help from a dietitian, can lower blood pressure in adults with hypertension. Researchers in Florida, Georgia, and Tennessee are looking for 150 participants with high blood press…

This study tests a device called the Carillon Mitral Contour System in 300 people with heart failure and a leaky mitral valve. The device is placed in a vein to help the valve close better, aiming to reduce symptoms and hospital stays. Participants are randomly assigned to get th…

This study tests whether adding a specially trained doula to standard care helps new mothers with pregnancy-related high blood pressure improve their blood pressure one year after giving birth. About 454 women who had preeclampsia or similar conditions will be randomly assigned t…

This study tests a home-based cardiac rehabilitation program delivered through a custom mobile app for 100 adults with heart failure. Participants are randomly assigned to either the app-based program or usual care. The goal is to see if the app helps increase physical activity, …

This study looks at whether a lower dose of aspirin (50 mg daily) works as well as the standard dose (100 mg) to prevent heart attacks and strokes in people aged 60 and older with heart disease. It involves over 5,400 Chinese participants who will be followed for about 6 years. T…

This study tests whether drinking traditional kefir for 12 weeks can improve blood sugar control and heart health in people who are overweight and either at risk for or already have type 2 diabetes. Researchers will measure changes in HbA1c (average blood sugar) and other health …

This study looks at whether a dual bronchodilator (a type of inhaler that opens airways) can improve both breathing and heart function in people newly diagnosed with moderate-to-severe COPD. Researchers will measure exercise capacity, quality of life, and lung function over 12 we…

This study tests a streamlined version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys to lower blood pressure. The goal is to see if a faster approach works just as well as the standard method. About 130 adults with uncontrolle…

This study tests a prescription wrist device called NightWare in 125 veterans with PTSD who have frequent nightmares. The device aims to improve sleep quality, which may also reduce the risk of heart disease. Researchers will measure sleep, blood vessel health, and nervous system…

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV who are on effective treatment. About 121 adults aged 40 and older with controlled HIV and at least one heart risk factor will receive …

This study is testing whether colchicine (a drug used for gout) and non-enteric coated aspirin, taken alone or together, can reduce the risk of serious heart problems like heart attacks and strokes in people with type 2 diabetes. The trial will include 10,000 adults aged 55 to 80…

This study looks at whether adding occupational therapy and dietitian services to home-delivered meals can reduce fall risk in older adults who have trouble leaving home. About 750 people aged 60 and older will receive either meals alone, meals with dietitian support, meals with …

This study tests a special PET/CT scan using a new tracer called [68Ga]Ga-NI-FAPI-04 to better see diseases linked to fibroblast activation, such as tumors, heart problems, lung scarring, and immune conditions. About 30 adults, including healthy volunteers, will get the scan to s…

This study tests a portable EEG device called StrokePointer that ambulance crews can use on people with suspected stroke. The goal is to see if it can accurately identify patients with a large vessel occlusion stroke, who need to go directly to a hospital that offers a specialize…

This study aims to see if voice recordings can help detect pulmonary hypertension, a serious heart and lung condition. Researchers at Mayo Clinic will collect voice samples from 7,000 people already scheduled for an echocardiogram. They will compare voice patterns to standard tes…

This study is testing whether a new smartphone-based 12-lead ECG device can accurately diagnose heart attacks (STEMI and NSTEMI) compared to standard hospital ECG machines. About 1,000 adults with chest pain will be enrolled in emergency departments. The goal is to see if the por…

This study tests whether starting cholesterol-lowering treatment in the emergency department can help prevent future heart attacks and strokes. It involves 130 adults aged 40-75 who are at risk for heart disease but not yet on preventive medication. The approach follows national …

This study tests whether daily aspirin and high-intensity statins can prevent heart attacks, strokes, and other serious heart events in people aged 40-70 with severe coronary calcium (score ≥300). About 5,000 participants will be randomly assigned to take aspirin or not, and a st…

This study looks at a program called Healthy School Recognized Campus, which helps schools in Texas offer more physical activity and nutrition programs for students. About 900 kids in 4th through 9th grade will take part. Researchers want to see if the program improves body mass …

This study tests a program called Mom♥Health that helps mothers of young children lower their risk for heart disease. About 40 moms will join the program through their child's daycare center. Researchers will check if the program is easy to use and if it helps moms schedule healt…

This study looks at whether telling people their genetic risk for heart disease, along with personalized advice, helps them adopt healthier habits. About 650 hospital staff members aged 40 and older will get genetic testing and a one-on-one meeting with a heart doctor. The goal i…

This study tests low-cost treatments to help Hispanic adults with prediabetes and obesity bring blood sugar back to normal, lose weight, and lower heart disease risk. Researchers will measure changes in blood sugar, body fat, and heart function. The goal is to find affordable str…

This study looks at whether treating ongoing sleep problems after PTSD therapy can also improve heart health in older adults. About 167 veterans aged 50 and older with PTSD and insomnia will receive talk therapy for PTSD, followed by a non-drug sleep program if needed. Researcher…

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in hospitalized heart patients. Frailty makes people more vulnerable to complications and longer hospital stays. The program includes standing, light exercise, and activity tracking. Resea…

This study tests if a personalized, app-based exercise program can reduce symptoms like heart fluttering and shortness of breath in people with atrial fibrillation (AFib). Researchers will enroll 120 adults with AFib who are already somewhat active. Participants will use a sensor…

This study tests whether adding extra booster sessions and a website to an 8-week mindfulness program delivered by phone can further reduce stress, anxiety, and depression in people with heart disease or risk factors. About 160 participants will be enrolled. The goal is to improv…

This study tests a new type of stroke rehabilitation that combines mirror therapy with other techniques to help people who had a stroke at least 3 months ago. The goal is to improve arm movement, strength, and daily life skills. About 81 adults aged 20-80 will participate, and th…

This study tests a new program called 'One Mind One Heart' that combines mindfulness and behavior change to help older adults with HIV reduce stress and improve heart health. Researchers will first interview 20 participants to refine the program, then test it in a small group of …

This study compares a women-only cardiac rehabilitation program to the standard mixed-gender program. Researchers want to see if women attend more sessions and have better heart health results when rehab is tailored just for them. The study involves 60 women aged 40-80 with heart…

This study tests whether a specific nerve block (called PIFB) can help people recover better after open-heart surgery. About 123 adults having planned heart surgery will receive either this block or another standard block. The goal is to see which method reduces pain and improves…

This study tests whether giving iron through a vein can improve quality of life and exercise ability in older adults with a narrowed heart valve and low iron levels after a minimally invasive valve replacement. About 400 participants will be randomly assigned to receive either ir…

This study looks at how two different virtual exercise programs affect exercise ability in women with coronary heart disease. Participants will be randomly assigned to either high-intensity interval training or moderate continuous training, exercising twice a week for 12 weeks. T…

This study tests whether adding a special sleep and stress program (called RESST) to standard cardiac rehabilitation helps people with heart disease recover better. About 200 adults who have sleep or stress issues will take part. Researchers will track sleep quality, stress level…

This study tests a non-invasive spinal stimulation technique to help control blood pressure in people who had a spinal cord injury within the past month. Many of these individuals experience dangerous drops in blood pressure when sitting up, causing dizziness and nausea that can …

This early study tests a new device called the A-FLUX Reducer for people with chest pain caused by small heart vessel disease (microvascular dysfunction). The device is placed in a vein near the heart to improve blood flow and reduce symptoms. About 30 adults with persistent ches…

This study looks at whether adding a whey protein-enriched milk fat globule membrane supplement to a high-fat meal can improve heart and brain health in postmenopausal women who are overweight and at moderate risk for heart disease. Sixteen women will attend two full-day visits, …

This study tests whether a type of talk therapy called Behavioral Activation, delivered via video calls at home, can improve social functioning and mood in veterans recently hospitalized for heart disease. About 132 participants will receive either 12 therapy sessions or standard…

This study is testing whether a special video game that involves physical activity (exergaming) can help people with heart failure sit less and move more. 750 inactive heart failure patients will either get standard activity advice or a tailored exergame program for 3 months. The…

This study tests whether gentle electrical stimulation on the back can help people with chronic spinal cord injury maintain healthy blood pressure when they sit up. Participants will lie on a tilt table while their blood pressure is measured with and without stimulation. The goal…

This study tests an 8-week program called Healing Hearts Together (HHT) for couples where one partner has heart disease. About 608 couples will be randomly assigned to the program or usual care. The goal is to see if the program improves relationship quality, mental health, quali…

This study aims to understand how the trillions of bacteria living in our bodies (the microbiome) are linked to cancer and heart disease. Researchers will collect samples and health information from 16,000 adults over age 40. The goal is to build a large database that can help fu…

This study is a Danish national registry that will follow 160 patients with resistant high blood pressure caused by narrowed kidney arteries. Participants will undergo a procedure called percutaneous transluminal renal angioplasty (PTRA) to open the narrowed arteries. The main go…

This study looks at how living in greener neighborhoods affects heart health and overall well-being. Researchers will measure changes in artery stiffness, blood pressure, and body composition in 835 adults aged 30-70 over two years. The goal is to understand if adding green space…

This study will check 3,000 adults with heart disease (coronary artery disease, atrial fibrillation, or heart failure) to see how many also have COPD. It will then test whether managing both heart and lung conditions together can lower hospital readmission rates. The goal is to i…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to look for biological markers that could help understand these conditions better. The goal is to support…

This study checks how well a new non-invasive device (Cardiac Performance System) measures heart function compared to the standard invasive catheter procedure. About 1,000 adults who are already scheduled for a heart catheterization will take part. The goal is to see if the new d…

This study is creating a biobank—a collection of DNA samples and health information—from 500 adults. Researchers will use this resource to study genetic links to heart disease, high blood pressure, diabetes, and obesity. The goal is to provide a valuable tool for future medical d…

This study collects blood and tissue samples from 500 people having heart surgery at the University of Chicago Medical Center. Researchers will study these samples to learn more about heart disease and how to improve treatments. Participants do not receive any new treatment—they …

This study is a large registry that will follow 5,000 people who receive Medtronic heart devices. Its goal is to confirm the devices are safe and work well in everyday use, and to spot any new risks. No experimental treatment is given—just careful observation of routine care.

This early study looks at whether products made from Chardonnay grape leftovers (marc) can improve heart and blood vessel health. Five adults with higher body weight and slightly reduced blood vessel function will take these products. Researchers will measure blood vessel flexibi…

This study reviews medical records from over 1,200 people who survived immune thrombotic thrombocytopenic purpura (iTTP), a rare and life-threatening blood disorder. Researchers aim to understand long-term risks like heart disease and stroke, and how newer treatments affect survi…

This study is creating a large registry of 600 people with immune-mediated inflammatory diseases (IMIDs) like arthritis or lupus to track their heart health over time. Researchers will collect routine medical data and blood samples to see if certain heart markers can predict futu…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their treatment plans. Researchers will enroll 3,100 adults with cardiovascular, endocrine, immune, neurological, cancer, or rare diseases across Europe. The goal is…

This study is testing whether a special heart scan (CTCA) can better identify kidney transplant candidates at highest risk for heart attacks or heart-related death. Current methods often miss those most at risk. The study will follow 332 adults on the transplant waiting list to s…

This study looks at tiny particles called extracellular vesicles that are released from fat cells. Researchers want to understand how these particles carry signals that may affect the heart and liver, especially in people with obesity. About 100 adults having weight-loss surgery …

This study looks at how sleep and the body's internal clock influence blood pressure in people with hypertension. Researchers will monitor 32 adults aged 25-64 to understand why some people's blood pressure doesn't drop enough at night. The goal is to uncover mechanisms behind th…

This study aims to create an AI tool that can predict a person's risk of developing five common diseases: type 2 diabetes, heart disease, breast cancer, low back pain, and osteoarthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical reco…

This study follows 300 people having weight-loss (metabolic) surgery to see how their gut bacteria change and how that affects heart health and diabetes. Researchers collect stool, blood, and tissue samples before and up to 3 years after surgery. The goal is to learn which gut mi…

This study collects small heart tissue samples from 400 adults with heart conditions during routine procedures. Researchers will analyze these samples to find new markers that help diagnose and understand different heart diseases. The goal is to improve future treatments, but no …

This study is a worldwide registry that will follow 5,000 adults with breast cancer, blood cancers, or those on certain immune therapies. Its goal is to collect data on patients' health, treatments, and heart events to better understand and predict heart problems caused by cancer…

This study aims to find the genes responsible for bicuspid aortic valve (BAV), a common heart defect where the valve has two flaps instead of three. Researchers will collect blood samples from 700 people with BAV and their relatives to compare DNA. The goal is to better understan…

This study looks at whether giving patients who come to the emergency room with chest pain their heart test results can help them understand their risk of future heart problems. Researchers will have a short conversation with 118 adults in Scotland about their heart health and se…

This study will gather medical records, DNA samples, and follow-up data from 1000 adults with panvascular disease (blockages in multiple blood vessel areas). Researchers will analyze this information to better understand what causes these conditions and how to improve treatment. …

This study looks at whether a type of artificial intelligence (AI) can help doctors better identify complications in people with rheumatoid arthritis (RA). Researchers will use AI to suggest possible complications from patient records and see if doctors agree with and use those s…

This study collects blood samples from 1,500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center in France. The goal is to improve early warni…

This study will see if an artificial intelligence (AI) model can predict serious heart problems within 30 days after gastrointestinal surgery better than current risk scores. Researchers will review medical records from 5000 adults having surgery at Bach Mai Hospital. The AI mode…

This study tests whether temporarily stimulating a specific part of the brain can improve hand, arm, and speech abilities in people who had a stroke at least 6 months ago. Ten participants will have a thin wire placed in the brain for less than 30 days to deliver mild electrical …

This study looks at whether measuring blood flow in the skin can help detect early signs of heart disease. Researchers will study 900 people aged 60-75, using special devices to check tiny blood vessels in the skin and comparing results with heart scans. The goal is to find simpl…

This study is testing a web-based app called IAMABLE that shares rehabilitation strategies for people with chronic conditions like heart disease, muscle or joint problems, and nerve disorders. Researchers will enroll 50 adults aged 45 to 75 across five Canadian cities. Half will …

This study follows 500 American Indian adults with chronic kidney disease to learn what makes the disease worse and how it affects the heart. Participants will have regular check-ups and tests over time. The goal is to find better ways to prevent kidney failure and heart problems…

This study is looking for new genes and blood markers that can help predict who will get arrhythmogenic cardiomyopathy (AVC), a genetic heart condition that can cause sudden cardiac arrest. Researchers will enroll 1000 people, including patients with AVC or unexplained cardiac ar…

This study looks at how genes influence fat buildup in the liver and whether that fat raises the risk of liver damage and heart problems. Researchers will study 2500 blood donors aged 40-65 who are overweight or have related health issues. The goal is to use genetic information t…

This study is looking at whether people with psoriasis have a higher risk of heart disease. Researchers will follow 1,000 adults with psoriasis, using heart scans and blood tests to find early warning signs. The goal is to better understand the link between psoriasis and heart pr…

This study looks at the diet, heart health, body composition, and mental well-being of 600 U.S. Army soldiers. Researchers will collect information through surveys, physical tests, and blood samples. The goal is to understand how nutrition and health affect soldier performance an…

This study is creating a large collection of blood, tissue, and health information from 15,000 people, including those with heart conditions like aortic aneurysm and heart failure, as well as healthy volunteers. The goal is to provide researchers with a valuable resource to bette…

This study looks at 250 heart surgery patients to see if their nutritional status before surgery affects how well they recover. Researchers will use questionnaires, blood and urine tests, and strength measurements to assess nutrition. They want to find out if poor nutrition leads…

This study aims to find out how common chronic kidney disease (CKD) is in semi-rural Sub-Saharan Africa and what factors increase the risk. Researchers will follow 1,200 adults for one year, measuring kidney function and checking for conditions like diabetes, high blood pressure,…

This study explores how a natural heart hormone, called natriuretic peptide, influences metabolism and exercise in people with different genetic makeups. Researchers will measure hormone levels and energy use in 200 adults after a sugary drink and exercise. The goal is to underst…

This study is for people aged 5 and older who have a disease related to blood clots, the immune system, or blood vessels, as well as their healthy relatives and unrelated healthy volunteers. The goal is to understand how these conditions start and change over time by collecting m…

This study follows people aged 12 and older who have a genetic heart condition called PKP2-ACM. Researchers will monitor heart rhythms, biomarkers, and quality of life over time to better understand how the disease naturally progresses. No new treatments are given; participants c…

This study looks at how healthy behaviors like diet, exercise, stress, and sleep relate to heart health in both adults and children. Researchers will collect data from questionnaires and simple health checks like blood pressure and blood sugar. The goal is to better understand th…

This study looks at how exercise affects people with ME/CFS (chronic fatigue syndrome) compared to those with heart disease. Both groups often feel tired or unwell after activity, but researchers want to see if the type and timing of symptoms are different. 80 adults will do a cy…

This study aims to make stress echocardiography—a common heart test—more accurate by using machine learning to analyze the images. Researchers will enroll 1250 people to develop computer tools that measure heart function during stress, helping doctors spot those at risk of a hear…

This study is testing a digital tool called PREVENT that helps doctors and patients work together to improve heart health. It is for low-income, rural adults with obesity who are at risk for heart disease. The tool shows patient information and suggests personalized goals for hea…

This study aims to improve how we detect and understand heart disease using a new type of MRI that looks at the heart's microscopic structure. Researchers will compare these advanced scans with standard tests and blood work in 1,000 adults, both healthy volunteers and those with …

This study will use advanced heart MRI scans on up to 100,000 people with known or suspected heart disease. The goal is to learn how these scans can give doctors a better understanding of heart conditions, help guide treatment decisions, and predict long-term health outcomes. Par…

This study explores how brief psychological stress affects heart and brain health in 450 midlife adults. Participants complete questionnaires, physical tests, and a stressful task while heart activity is measured. They also undergo brain scans and memory tests. The goal is to und…

This study follows 10,000 adults aged 18 and older over many years to see if a set of health measurements can predict how long people live and what diseases they may get. Participants undergo health screenings and are followed until death. The goal is to better understand aging a…

This study is creating a massive collection of medical images (CT and MRI scans) and health information from 50,000 adults. Researchers will use this data to find hidden patterns in images that could help predict, diagnose, and treat diseases like cancer, heart disease, and brain…

This study looks at how small changes in your genes might affect the body's natural ability to control inflammation. Inflammation is a normal response to injury or illness, but when it goes unchecked, it can lead to diseases like rheumatoid arthritis and heart problems. Researche…

This study follows 1,000 adults aged 50 and older who take part in a park-based fitness program in Miami-Dade County. Researchers will measure changes in weight, blood pressure, arm and leg strength, and mobility over time. The goal is to see if community exercise programs can im…

This study uses special MRI scans to see how the heart's structure and energy use change after bariatric surgery or cardiac rehab. Researchers will scan 150 adults before and 6-12 months after these treatments. The goal is to understand how these metabolic interventions affect he…

This study looks at whether obesity raises heart disease risk in African American men and women. Researchers will measure body fat, blood fats, and how well insulin works in 2000 healthy non-diabetic adults. The goal is to understand why heart disease risk factors may differ betw…

This study looks at whether CT scans can be used to check heart tissue health, similar to how MRI does now. MRI is the current best method but has limits—it can't be used in people with certain devices, takes a long time, and can't see the heart's arteries. CT scans are faster an…

This study aims to see if voice recordings from smartphones can help detect heart disease. Researchers will collect voice samples and health data from up to 1 million adults using a Mayo Clinic app. No treatment is given—the goal is simply to gather information for future AI mode…

This study is following 2,500 adults in Puerto Rico, ages 30 to 75, to learn how stress, diet, and living environment affect chronic diseases like heart disease, diabetes, and obesity. Researchers will collect health data and survey participants over two years. The goal is to gui…

This study tests whether artificial intelligence (AI) can plan heart MRI scans as well as expert radiographers. About 150 adults will get both an AI-planned and a radiographer-planned scan. The goal is to see if AI can speed up the process and maintain image quality, which could …

This study looks at why women who had high blood pressure during pregnancy are more likely to develop heart and blood vessel problems later in life. Researchers will use MRI scans to measure heart structure in 200 women who gave birth 10 to 25 years ago. The goal is to better und…

This study follows 650 adults who had pneumonia (including COVID-19) to see how their heart health changes over 3 years. Researchers will track heart attacks, strokes, and other serious events. The goal is to find early warning signs and better ways to prevent heart problems afte…

This study looks at how a short course of high-dose statins affects fatty buildup (plaque) in the heart arteries of 140 people with mild blockages. Participants get either statins or a placebo for 3 months, and advanced CT scans track plaque changes. The goal is to understand who…

This study aims to learn how the body responds to kidney nerve stimulation in people with high blood pressure. Researchers will measure these responses before and after a procedure that quiets certain kidney nerves. About 19 adults with hypertension will take part. The goal is to…

This study looks at how aging changes the way our bodies respond to exercise. Researchers will have 26 older adults who previously completed an exercise program do another 6 months of aerobic training. The goal is to measure changes in insulin sensitivity, fitness, and overall he…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information so that future researchers can use them to discover what…

This study follows 300 babies born early (preterm) and at full term to understand how early birth affects kidney and heart health later in life. Researchers use ultrasound and blood/urine tests to spot early warning signs of kidney disease and high blood pressure. The goal is to …

This study is testing a virtual patient navigation program for 260 underserved adults who speak English, Chinese, or Spanish and have breast cancer or heart disease. The program uses a phone-based portal to connect patients with navigators who can help them manage their care. The…

This study looks at why people with hemophilia (a bleeding disorder) are less likely to die from heart disease. Researchers will use a new, detailed CT scanner to compare plaque buildup in the heart arteries of 80 men with hemophilia to men without it. The goal is to understand h…