CARDIOVASCULAR DISEASES

This study tested whether a stricter blood pressure target (below 135/85 mmHg) is better than usual care (below 150/100 mmHg) for women who had high blood pressure during pregnancy. 61 women were enrolled shortly after delivery and followed for six months. The goal was to see if …

This study tested a virtual world-based cardiac rehabilitation program called 'Destination Cardiac Rehab' for people with heart conditions. Over 2,800 participants were randomly assigned to either the virtual program or traditional in-person rehab. The goal was to see if the virt…

This study looked at whether a whole food plant-based diet, low in red and processed meats, can lower LDL cholesterol in 50 adults with heterozygous familial hypercholesterolemia (HeFH), an inherited condition causing high cholesterol. Participants followed both a standard North …

This study looked at whether eating fewer ultra-processed foods (like packaged snacks and sugary drinks) can improve blood vessel health in middle-aged adults. Seventeen people took part and ate specially prepared meals for 8 weeks. The goal was to see if this diet change could l…

This study looked at whether a 16-week strength training program could help adults who had a bone marrow transplant as children. These survivors often face early health issues like muscle loss, heart disease, and diabetes. The study included 28 participants and a control group, b…

This study looked at whether sending lifestyle tips and reminders via text message could help people who had a heart attack (acute coronary syndrome) better manage their risk factors and avoid future heart problems. 370 patients took part and received text messages for one year. …

This study tested a special walking program for people who had a stroke at least six months ago. The program mixes robot-assisted walking practice with regular walking training to help improve how well they can walk, while also helping with weight and blood pressure control. 140 …

This study tested a drug called tovinontrine in 303 adults with chronic heart failure where the heart pumps normally but is stiff. The goal was to see if the drug lowers a key heart stress marker (NT-proBNP) compared to a placebo over 12 weeks. Participants had symptoms like shor…

This study tested a 6-month program that taught nutrition and exercise to 50 mothers and their children (ages 7-12) in the Yaqui Valley, Mexico. The goal was to improve lifestyle habits and reduce risk factors for heart disease and type 2 diabetes. Researchers measured weight, bl…

This study looked at whether a Mediterranean diet and more physical activity could improve heart health in 150 women who finished breast cancer treatment and are on hormone therapy. The women learned about healthy eating and exercise, and researchers tracked changes in weight, wa…

This study tested a special coaching program for older adults (70+) who had a heart event, like a heart attack or heart surgery. The goal was to help them complete cardiac rehabilitation and improve their physical function. 416 participants were randomly assigned to either the co…

This study tested a digital quality improvement program to help people with heart disease lower their LDL (bad) cholesterol. Over 1,400 patients in Brazil used a smartphone-based tool to improve cholesterol management. The goal was to see if this approach helps doctors and patien…

This study tested a 12-week program where people with overweight or obesity, who were already taking weight-loss medications, used a Fitbit and worked with a health coach. The goal was to see if this approach could help them become more active and improve their health. Fifteen pa…

This study looked at how different amounts of aerobic exercise (like walking or cycling) affect the health of people with heart disease. 115 participants in a cardiac rehab program had their skin blood flow, oxygen use, and weight measured. The goal was to see which exercise volu…

This study tested whether colchicine, an anti-inflammatory drug, can reduce inflammation in the arteries of people with diabetes or pre-diabetes who recently had a heart attack or stroke. 115 participants received colchicine or placebo, and researchers used PET scans to measure c…

This study tested a new device called NEURESCUE in 6 adults having a cardiac arrest in the hospital. The device uses a soft balloon in a major artery to quickly send more blood to the heart and brain during CPR. The main goal was to see if doctors could place the balloon within 1…

This study tested a device called MitraClip, which clips a leaky heart valve, in 304 people with severe mitral regurgitation and heart failure. Participants either got standard care alone or standard care plus the clip procedure. The goal was to see if the clip could lower deaths…

This study looked at whether a 12-week program of aerobic and strength exercises could improve heart health in women who had finished treatment for endometrial cancer. Thirty-three women in remission took part. They received exercise equipment and a Fitbit, and had their blood ve…

This study looked at whether drinking Dachundou No Sugar Added Soymilk every day for 8 weeks could help lower cholesterol in adults with high cholesterol. 25 people with total cholesterol of 200 mg/dL or higher took part. Researchers measured cholesterol, blood pressure, and othe…

This study tested a very small balloon catheter (0.85-1.25 mm) in 170 people with completely blocked heart arteries (chronic total occlusion). The balloon was used to open the blockage before placing a stent. Researchers checked if the balloon could be safely delivered, inflated,…

This study compared a once-daily pill called orforglipron to insulin glargine in about 2,700 adults with type 2 diabetes who were also overweight or obese and had increased heart or kidney risk. The main goal was to see if orforglipron could delay or prevent major heart problems …

This study tested a new heart valve (SAPIEN XT) in 57 people whose surgically-placed valve or tube between the heart and lungs was not working properly. The goal was to see if the valve could safely reduce leakage or blockage without needing another open-heart surgery. The study …

This study tested a nurse-led phone program to help 500 recent stroke patients in Ghana control their blood pressure. Participants received regular calls and guidance to manage hypertension, a major stroke risk factor. The goal was to see if this approach could lower blood pressu…

This study looked at whether using social networks (like WeChat) can help people at high risk for stroke take their medicines correctly and control risk factors after leaving the hospital. About 720 adults who had a stroke or were at high risk took part. The goal was to see if so…

This study tested a new medicine called olezarsen in about 1,500 adults with very high triglycerides (a type of blood fat) and either heart disease or high risk for it. The goal was to see if olezarsen could lower triglyceride levels more than a placebo over 25 weeks. Participant…

This study tested a drug called alirocumab in 118 people with HIV who were at risk for heart disease. The drug aims to lower cholesterol and reduce inflammation in the arteries, which can lead to heart attacks. Participants received either the drug or a placebo for about a year, …

This study tested whether a chewing gum containing dietary nitrate (a natural compound found in leafy greens and beets) could improve gum health and heart health in adults with mild to moderate gum irritation or bleeding. Thirty participants were randomly assigned to use either t…

This study tested an experimental pill called ralinepag for people with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work too hard. About 687 adults with PAH took either ralinepag or a placebo on top of their usual treatments. The goal was …

This study tested whether teaching dialysis clinic staff and encouraging patients to speak up could reduce dangerous drops in blood pressure during treatment. Over 1,400 people with kidney failure took part across multiple clinics. The goal was to make dialysis sessions safer and…

This study tested a behavioral program to help young adult cancer survivors (ages 18-39) with obesity manage their weight and related symptoms like pain, fatigue, and distress. The goal was to reduce their risk of heart disease, a leading cause of death in this group. 38 survivor…

This large study tested whether the statin drug pitavastatin could lower the risk of heart attacks, strokes, and other serious heart problems in people with HIV. Over 7,700 adults with HIV who were already on standard HIV treatment took either pitavastatin or a placebo pill. The …

This study tested a new device called the Supernova stent retriever to treat acute ischemic stroke, which happens when a blood clot blocks blood flow to the brain. The device is designed to remove the clot and restore blood flow. The trial involved 54 adults aged 18-85 who had a …

This study tested whether two common blood pressure medicines (ACE inhibitors or ARBs) could help high-risk COVID-19 patients avoid intensive care, a ventilator, or death. About 372 adults with COVID-19 and heart disease risk factors took part. Researchers tracked outcomes like I…

This study tested a new drug called tovinontrine in 557 adults with chronic heart failure and reduced pumping ability. The goal was to see if the drug could safely lower a key heart stress marker (NT-proBNP) compared to a placebo over 12 weeks. Participants had heart failure symp…

This study looked at whether taking two blood thinners (clopidogrel and aspirin) for a longer time after getting a heart stent helps prevent future heart attacks, strokes, or death in people with multiple blocked heart arteries. About 8,250 adults aged 18-75 who already had a ste…

This early-stage study tested a single dose of Kylo-11 in 71 healthy adults with high levels of Lp(a), a protein linked to heart disease. The main goal was to check safety and how the drug moves through the body. Researchers also looked at whether Kylo-11 could lower Lp(a) levels…

This study tested a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys, to see if it can safely lower blood pressure in people whose hypertension is not controlled by up to three medications. The study involved 337 participants and meas…

This study tested a new way to treat high blood pressure without pills. Doctors used focused ultrasound to modify fat around the kidney in 79 patients with mild hypertension who were not on medication. The goal was to see if this procedure could safely lower blood pressure compar…

This study tested whether a simple checklist called the YEARS algorithm can safely rule out dangerous blood clots in the lungs (pulmonary embolism) in cancer patients, reducing the need for CT scans. Researchers compared the YEARS approach to standard CT scanning alone in 698 adu…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. Researchers enrolled 253 women aged 65 and older with a history of cardiovascular disease who were not alrea…

This study tested a lifestyle program designed for rural families at high risk for heart disease and type 2 diabetes. Over 500 Hispanic and non-Hispanic adults participated, focusing on healthy eating, physical activity, and weight management. The goal was to see if a culturally …

This pilot study looked at whether a 12-week virtual exercise program could help women with cardiac implantable electronic devices (CIEDs) improve their fitness, quality of life, and mental health. Twenty women were randomly assigned to either high-intensity interval training (HI…

This early-phase study tested a new way to deliver nitric oxide—a molecule that relaxes blood vessels—by placing a mixture under the tongue. Fourteen healthy adults took part to see if this method safely lowers blood pressure. The goal is to find an alternative to current nitrate…

This study tested whether a simple mental exercise called evaluative conditioning could help people who had a heart attack exercise more intensely during cardiac rehab. Twenty-four patients were split into two groups: one received exercise-friendly conditioning, the other diet-re…

This study looked at whether online referrals from doctors to the WIC food program help more pregnant women enroll. About 240 pregnant women on public insurance or uninsured took part. Some got usual care, others got a direct referral or extra dietitian support. The goal was to s…

This study looked at why people with rheumatoid arthritis (RA) often miss out on cholesterol checks and treatments that can prevent heart attacks and strokes. Researchers worked with 101 adults aged 40-75 who have RA but were not taking cholesterol-lowering medication. The goal w…

This study followed over 18,000 Taiwanese adults to see if a vegetarian diet is linked to a lower risk of chronic diseases like dementia, depression, heart disease, stroke, gout, cataracts, gallstones, and urinary tract infections. Researchers used health insurance records to tra…

This study looked at whether a new tool could help elementary schools in Oakland, California follow state physical education (PE) laws more closely. Many schools, especially those serving mostly non-white and low-income students, do not meet PE requirements, which can lead to hea…

This study looked at 313 children with and without congenital heart disease to see if blood tests and non-invasive heart scans could help detect heart problems early and predict which children might need surgery or other procedures. The goal is to improve screening and care for c…

This study aimed to find out if silent myocardial ischemia—a condition where the heart doesn't get enough blood without causing chest pain—raises the risk of heart-related death or problems in people with coronary heart disease. Researchers followed patients for one to three year…

This study looked at whether problems with tiny energy factories inside cells (mitochondria) contribute to higher blood pressure and worse blood vessel health in Black adults. Researchers gave 31 middle-aged and older adults a supplement called MitoQ or a placebo for 8 weeks. The…

This study looked at 485 patients who had coronary artery bypass surgery to see if a computer method called fuzzy logic could help predict who is at highest risk of dying. Fuzzy logic is a way for computers to handle uncertain information, similar to how doctors think. The resear…

This study looked at 40 adults to see if high levels of lipoprotein (a), a fatty substance in the blood, affect the number of stem cells that repair blood vessels. Researchers compared people with high and normal levels of this substance. The goal was to better understand how lip…

This study tested a new way to calculate heart disease risk during routine NHS Health Checks in GP surgeries. 862 adults aged 45-64 took part to see if the tool was easy to use and helpful. The goal was to see if it could be smoothly added to everyday primary care.

This study looked at whether a fitness test can predict heart problems in adults who survived Hodgkin lymphoma after chemotherapy and radiation. It also tested if exercise training can improve their physical fitness and heart function. 40 survivors took part to help doctors under…

This study looked at whether fatty liver disease can be an early warning sign for heart problems, separate from known risks like high cholesterol. Researchers measured blood markers of liver and blood vessel health in 63 adults aged 50-69 who did not have diabetes. The goal was t…

This pilot study tested an indoor air pollution program called AIRWISE in 20 adults aged 55 and older with heart disease. The program included air purifiers, a color-changing air quality monitor, and educational materials to help people reduce their exposure to indoor air polluti…

This study looked at whether replacing sitting time with standing and walking can improve daily blood sugar levels in South Asian adults who are overweight or obese. Eighteen participants changed their daily routines to sit less and move more. The results showed that this simple …

This study followed 6,000 adults who had COVID-19 symptoms to understand long-term health problems like chronic fatigue, heart issues, and brain fog. Participants completed online surveys every 3 months for 18 months. The goal was to learn how the virus affects people over time, …

This study aimed to improve genetic counseling for people of all backgrounds. Over 1,000 adults referred for genetic counseling completed surveys and had their sessions recorded. Researchers tested different counseling methods to see which led to better patient experiences, espec…

This study looked at how social factors like income, housing, and stress, along with depression, affect blood vessel health in 105 low-income racial and ethnic minority adults. Participants completed questionnaires about their mental health, social needs, and lifestyle. The goal …

This study aimed to understand why Black older adults with type 2 diabetes spend long periods sitting and how to help them move more. Researchers worked with 33 participants to design practical strategies for breaking up sedentary time. The goal was to improve heart health and bl…

This study tested a workplace wellness program designed to reduce stress and improve heart health in long-term care workers. It included 159 staff and residents. The goal was to see if the program was practical and effective, and if healthier staff could positively influence resi…

This study looked at how quickly a short break from exercise (3 days of reduced activity) affects blood vessel function and blood sugar control in active older adults compared to younger adults. Researchers measured changes in blood sugar after a meal before and after the inactiv…

This study gathered information from 100 people undergoing a standard heart procedure to close a small pouch in the heart (left atrial appendage). Researchers used routine scans to see if a new software tool can measure the pouch as accurately as a CT scan. No extra tests or trea…

This study looked at whether deep cleaning of the gums (called intensive periodontal therapy) can improve not just oral health but also markers of heart disease and diabetes. About 200 adults with heart disease or type 2 diabetes received either the gum treatment or standard care…

This study looked at whether information from social media, online searches, and wearable devices can help predict heart disease and healthcare use. Researchers analyzed language from 781 adults aged 30-74 who shared their digital data. The goal was to find patterns in online beh…

This study tested a program called GRACE that helps primary care patients understand their genetic risk for conditions like heart disease and cancer. Researchers worked with 245 patients, their doctors, and family members to see if the program could be used in different clinics, …

This study looked at 320 adults who had heart surgery to see how well two risk scores (EuroSCORE-II and POSPOM) predict the chance of dying in the hospital. Researchers reviewed medical records from a single hospital between 2020 and 2024. No new treatments were given—the goal wa…

This study looked at two methods for assigning care coordinators to older adults (65+) who have heart disease or related risks like diabetes or high blood pressure. The goal was to see which method better prevents emergency room visits and hospital stays. Researchers compared ass…

This study tested a school program that encourages physical activity and healthy eating in 159 fifth and sixth graders in Texas. Researchers measured things like waist size, blood pressure, and fitness to see if the program could reduce risk factors for heart disease. The goal wa…

This study looked at whether people with inflammatory bowel disease (IBD) have a higher risk of developing atherosclerosis, a condition where arteries harden and narrow. Researchers measured artery stiffness and thickness in 115 adults with IBD. The goal was to understand the con…

This study measured two types of cells in the blood that reflect blood vessel injury and healing. Researchers wanted to see if these cell counts could predict major heart problems like heart attack or death within 6 to 12 months after a stent procedure. The study involved 170 adu…

This study looked at how stress, behavior, and social factors affect weight loss and heart health in people from disadvantaged backgrounds. Researchers tracked 15 adults with overweight or obesity to understand what helps or hinders weight management. The goal was to gather infor…

This study checked if the Cardiac Depression Scale works properly in Turkish for people with heart disease. Researchers tested 360 adults with stable heart conditions to see if the scale accurately measures depression. The goal is to give doctors a reliable way to detect depressi…

This study looked at 268 adults with kidney failure who were on dialysis. Researchers used portable heart monitors to track heart rhythm problems and blood sugar changes. The goal was to see how these issues relate to the risk of heart-related death or other serious heart events …

This study looked at how a four-week ketogenic diet changes cholesterol levels and heart health in healthy adults with a normal weight compared to those with obesity. Researchers wanted to see if the diet raises 'bad' cholesterol more in lean people and if it harms blood vessel f…

This study tested whether giving people their 'HeartAge' (a measure of heart health), genetic risk scores, and a digital behavior-change app could help them lower their risk of heart disease. Over 1,100 adults aged 30-74 with at least a 5% risk of heart disease participated. Rese…

This study looked at how heart disease and mental health problems like depression and anxiety are linked, and how things in the environment might play a role. Researchers studied 400 people with both heart disease and a mental health condition, using questionnaires and tests to f…

This study tested a new method to stop bleeding after a common heart procedure (transradial catheterization). The goal was to see if combining a lower dose of blood thinner with pressing on a nearby artery could reduce bleeding, bruising, and artery blockage. 451 adults took part…

This study looked at two medications, tocilizumab and methotrexate, to see which one better prevents major heart problems like heart attacks, strokes, or death in people with giant cell arteritis (GCA). Researchers analyzed data from over 1,600 patients in France who were newly t…

This study looked at how well Arab women in East Jerusalem understand health information and how to talk with their doctors. Researchers held focus groups to learn what these women need, then tested a 4-session workshop to improve heart disease knowledge and communication skills.…

This study looked at medical records of over 2,000 people with HIV from racial and ethnic minority groups to see if seeing a heart specialist (cardiologist) helps prevent heart disease. Researchers found that those referred to a cardiologist had better heart outcomes. The goal is…

This study looked at whether drinking a KETO5 XOGenius beverage every day could improve markers of heart health, blood pressure, cholesterol, and thinking skills. Six healthy adults aged 18 to 50 took part. The goal was to see if the drink might lower risks for heart disease and …

This study looked at 1,000 people who had a heart attack to understand why some had no common risk factors like smoking, high blood pressure, or diabetes. Researchers compared those with and without these risk factors to find new clues in blood tests, imaging, and medical history…

This study looked at how a high-dose fish oil supplement (E-EPA) affects LDL cholesterol in 68 healthy adults aged 18-65. Participants added the supplement to their normal diet for one month. Researchers measured how easily LDL cholesterol clumps together, which is linked to hear…

This study tested whether a systematic phone call from a medical student to older adults with heart disease or mental health conditions during the COVID-19 lockdown in France could reduce hospitalizations within one month. About 22,000 patients took part. The goal was to see if t…

This study tested whether giving heart attack patients telemedicine devices to use at home could safely reduce the need for hospital visits. 337 adults with high cardiovascular risk took part after leaving the hospital. Researchers tracked hospital readmissions and emergency visi…

This study looked at whether taking short, regular walks during long periods of sitting can help lower blood sugar and cholesterol after meals—key risk factors for Type 2 diabetes and heart disease. Researchers compared normal-weight and overweight/obese South Asian adults, a gro…

This study tested four simple behavior change techniques—goal setting, action planning, self-monitoring, and feedback—to see if they could help sedentary adults at risk for heart disease walk at least 1,000 more steps per day. Over 600 participants used a Fitbit and received text…

This study looked at whether older African Americans (55+) with heart disease risk factors could follow a special diet called MIND+SOUL. The diet combines brain-healthy foods with soul food traditions. Researchers measured how many people stuck with the diet and checked changes i…

This study looked at nearly 242,000 adults with type 2 diabetes to find out which glucose-lowering medications are best for heart health and other important outcomes. Researchers also examined whether benefits differ by age, sex, race, or kidney function. The goal is to help pati…

This study looked at whether certain gene changes make sudden cardiac death more likely. Researchers checked DNA from 2500 people for links to heart rhythm problems. The goal was to find genetic clues that could help predict risk, not to test a treatment.

This study followed 42 adults with spinal cord injury for one year after leaving rehab. Researchers tracked what they ate, how active they were, and factors like mood and kitchen access to understand why weight gain happens. The goal is to use this information to design better he…

This study tested whether giving African American patients in rural eastern North Carolina a personalized list of local resources (like food, housing, and transportation help) could improve their confidence in managing their heart health. Over 300 participants received a 'Healthe…