CARDIOVASCULAR DISEASES

This study looks at whether a program called Heart Matters can help Black adults in rural eastern North Carolina lower their blood pressure. About 173 people with heart disease risk factors like high blood pressure or obesity will take part. Community leaders will run the program…

This study tests a device that removes blood clots from the lungs of people with acute pulmonary embolism (a sudden blockage in lung arteries). About 125 adults with severe symptoms will be treated, and doctors will check if the device safely improves heart function within 48 hou…

This study tests whether a natural substance called spermidine can improve heart and muscle health in people aged 65 and older with coronary artery disease. Participants take spermidine or a placebo for a period, and researchers measure changes in heart mass, muscle mass, inflamm…

This study tests a new device called the Edwards EVOQUE system to replace the tricuspid valve in people whose valve leaks severely. The goal is to see if the device can safely reduce the leak and improve symptoms like shortness of breath and fatigue. About 864 adults with severe …

This study looks at whether eating walnuts can improve cholesterol levels, reduce inflammation, and change gut bacteria in overweight or obese adults aged 45-70 who have high LDL cholesterol. Participants will eat walnuts and have their blood, blood pressure, and stool checked ov…

This study compares a new leadless pacemaker (Micra AV) to a traditional pacemaker with wires in 100 adults aged 70 or older who need a pacemaker for a slow heartbeat. The goal is to see if the leadless version helps people exercise as well as the standard one. Participants are r…

This study tests an inhaled medicine called mosliciguat for people with high blood pressure in the lungs caused by scarring lung disease. About 135 adults will receive either the drug or a placebo for 16 weeks. The goal is to see if the drug improves blood flow in the lungs and w…

This study tests a special stent (a small mesh tube) coated with a drug that helps keep heart arteries open. It involves 591 people in China with narrowed arteries who need a procedure to restore blood flow. The goal is to see if the stent is safe and effective at treating blocka…

This study tests whether having extra appointments with a heart specialist at a local GP practice helps people at high risk get better treatment for heart, kidney, metabolic, and lung conditions. About 138 adults from a previous study (FIND-AF) will either receive these specialis…

This study looks at how well a special heart stent called Onyx works in everyday medical practice. About 4,500 adults with narrowed heart arteries who receive an Onyx stent will be followed to check for safety and effectiveness, such as whether the stent stays open and prevents h…

This study tests whether giving stroke patients a more thorough exam—looking at hidden causes like artery stiffness, 24-hour blood pressure, and leg circulation—can lower their chance of having another stroke or heart attack. About 600 people admitted to a Swedish hospital for st…

This study tests a clinic-based program called ActivityChoice that helps cancer survivors become more physically active to lower their risk of heart disease. About 114 adult cancer survivors will be offered a choice of group in-person, group virtual, or self-monitored digital exe…

This study tests a new device called the Aventus Thrombectomy System to safely remove blood clots from the lungs in people with acute pulmonary embolism. About 130 adults aged 18 to 80 with recent clot symptoms will be treated. The goal is to see if the device improves heart func…

This study was designed to test a special tube called the Versus Catheter for dissolving blood clots in the lungs. The goal was to see how well the catheter cleared clots and how easy it was for doctors to use. The study was withdrawn before any participants were enrolled, so no …

This study tested a new device called the Tendyne mitral valve, which is implanted without open-heart surgery to treat a leaky mitral valve (mitral regurgitation). About 103 people with moderate-to-severe symptoms took part, and some were compared to those receiving an existing d…

This study tests whether colchicine, a common anti-inflammatory drug, can reduce inflammation and lower the risk of heart disease in people with type 1 diabetes. About 100 adults aged 35-80 with type 1 diabetes will take either colchicine or a placebo daily for 26 weeks, with an …

This study looks at the long-term safety of a drug called ralinepag for people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who were in earlier ralinepag studies can join. The goal is to see if the drug is …

This study compares two drug-coated stents (SUPRAFLEX Cruz and SYNERGY) in about 1,550 people with severe blockages in three heart arteries. Participants receive modern heart care including imaging and medications. The goal is to see which stent is safer and more effective at pre…

This study tests a newer heart stent (Resolute Onyx) against an older one (Resolute Integrity) in 550 people in China with narrowed arteries. Both stents are drug-coated tubes that prop open arteries and release medicine to prevent re-blockage. The main goal is to see which stent…

This study looks at whether eating dark chocolate can improve key markers of heart health, like blood pressure, blood flow, cholesterol, and antioxidant levels. Researchers will compare regular dark chocolate, bloomed dark chocolate, and white chocolate in 45 generally healthy ad…

This study tests a new device called EVOQUE to replace the tricuspid valve in people with a leaky heart valve that causes symptoms despite medication. About 228 participants will get the device to see if it safely reduces the leak and improves their condition. The goal is to cont…

This study looks at a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys, to help lower blood pressure in people whose hypertension is not controlled by medication. About 1,900 adults with high blood pressure are taking part. The goal i…

This study looks at whether different levels of exercise can help the hearts of young adults who survived childhood cancer and were treated with a type of chemotherapy called anthracyclines. About 20 survivors aged 18-39 will take part. The goal is to see if exercise can reduce h…

This study tests whether using an insertable heart monitor to guide early treatment can reduce the amount of time people spend in atrial fibrillation (AFib) after a catheter ablation procedure. About 120 adults with AFib will receive the monitor and be followed for 15 months. The…

This study looks at how the timing of meals and sleep patterns impact blood sugar control, heart disease risk, and weight loss in adults with type 2 diabetes, high blood pressure, or obesity. Researchers will provide nutritional guidance and track changes in weight, blood tests, …

This study tests whether colchicine, an anti-inflammatory medicine, can slow the worsening of aortic valve stenosis—a common heart valve condition. About 150 adults with moderate, symptom-free valve narrowing will take colchicine or a placebo for up to 2 years. The goal is to see…

This study tests a new device called the Millipede Ring, which is placed inside the heart to help a leaky mitral valve close better. It is for people with moderate to severe functional mitral regurgitation who still have symptoms despite medication. The main goal is to see if the…

This large study tests whether lowering blood pressure more than usual can prevent major heart problems, strokes, and memory loss in people with type 2 diabetes. About 9,500 participants with high blood pressure and diabetes are being followed to compare intensive versus standard…

This study tests a proactive outreach program to help BIPOC adults who smoke quit tobacco. Researchers will use electronic health records to identify smokers and offer culturally tailored support, including counseling and medication. The goal is to reduce smoking rates and relate…

This study tests a device that uses ultrasound to calm overactive kidney nerves, which can help lower blood pressure. About 154 adults with high blood pressure who are already taking two medications will receive either the ultrasound treatment or a fake procedure. The goal is to …

This study checks if a special blood pressure monitor (Withings BPM Core) can correctly detect atrial fibrillation, a common heart rhythm issue. Researchers compared the device's readings to a standard 12-lead ECG in 160 adults. The goal is to see if this easy-to-use home device …

This study looks at better ways to check for heart damage in adults who have had cancer. Researchers are testing if an AI-powered ECG and a simple blood test can find early signs of heart problems. The goal is to create a nationwide screening program to help cancer survivors stay…

This study tests a targeted screening approach to detect undiagnosed heart failure in 706 adults aged 40+ with type 1 or type 2 diabetes who also have additional heart risk factors. Participants are randomly assigned to receive the screening or usual care, and researchers track h…

This study looks at whether heavy smokers at high risk for lung cancer can be screened every two years instead of every year with low-dose CT scans, without missing early-stage cancers. It also offers a smoking cessation program to help participants quit. The goal is to make lung…

This study tested whether a risk score based on health records can help find people with hidden atrial fibrillation (AF), a common heart rhythm problem that raises stroke risk. About 1,955 adults aged 30 and older with certain risk factors used a remote ECG monitor at home. The g…

This study compares two ways to prevent heart attacks in people at risk for heart disease. One group gets a CT scan of their heart arteries to guide treatment, while the other group follows standard care based on a risk score. About 6,100 adults aged 40-70 with risk factors like …

This study tests whether personalized counseling can help prevent high blood pressure in adults living in Dhaka slums. About 1700 healthy participants will receive 20 counseling sessions focused on exercise, diet, and avoiding tobacco and alcohol. The goal is to see if these talk…

This study tests whether a dedicated care coordinator can help people with psoriasis or psoriatic arthritis lower their risk of heart disease. About 520 adults aged 40-75 who are not already on cholesterol medication will receive support to manage risk factors like high cholester…

This study tests whether a structured exercise program can improve physical function and reduce disability in HIV-positive adults aged 50 and older in Côte d'Ivoire. Participants are randomly assigned to a supervised group exercise, a home-based program with phone support, or hea…

This study tests whether a 30-minute educational website helps people who stopped taking statins due to muscle symptoms make informed decisions about restarting the medication. About 816 participants will either use the website or receive usual care. The goal is to see if the web…

This study tests whether a smartphone mindfulness training program can help stressed adults aged 45 and older who are at risk for heart disease. About 106 participants will be randomly assigned to either use the app for four weeks or continue their usual routine. Researchers will…

This study tests a nurse-led group education program designed to improve sexual function, mood, and quality of life in women attending cardiac rehabilitation after a heart event. About 66 women will take part, and the program is added to their usual rehab care. The goal is to see…

This study aimed to understand how T cells contribute to blood vessel aging and heart disease risk. It planned to give an injection of abatacept to older adults (55-75 years old) and measure changes in artery function. However, the study was withdrawn before enrolling any partici…

This study looks at whether a high-sensitivity troponin blood test can more accurately predict a person's risk of heart disease than current methods. Researchers will track 300,000 adults during routine health checkups to see if the test helps classify people as low, moderate, or…

This study follows 500 people with peripheral artery disease (narrowed leg arteries) who undergo a procedure to restore blood flow. Researchers check blood for heart-damage markers and use heart ultrasound to find silent injuries that may raise future heart attack or stroke risk.…

This study checks how often hospital workers have high levels of lipoprotein(a), a type of fat in the blood that can raise heart disease risk. About 2,800 healthcare workers and their family members will give a blood sample. Researchers will track who later has heart problems, bu…

This study reviews over 2,500 medical records to understand why some people with treated and controlled high blood pressure still die from heart attacks, strokes, kidney failure, or sudden death. Researchers are looking for overlooked factors beyond blood pressure numbers. The go…

This study aimed to compare two FDA-approved devices used to seal the artery after a heart catheterization procedure. The goal was to see if using both devices together could shorten the time patients need to lie flat and recover. However, the study was withdrawn before enrolling…

This study looks at how the timing of meals affects the way the body uses energy (metabolism) and insulin sensitivity. Researchers will study 200 overweight or obese adults aged 30-75 who sleep 6.5-9 hours nightly. No treatment is given; the goal is simply to understand how eatin…

This study follows 200 women with breast cancer who are receiving doxorubicin and/or trastuzumab to see how these drugs affect heart function over time. Researchers will use echocardiograms, blood tests, and surveys to track changes and explore links to medical history and social…

This study is creating a large biobank of 48,000 people with diabetes in Hong Kong. Researchers will collect blood samples and health data to find genetic markers that predict serious complications like kidney failure, heart disease, and stroke. The goal is to improve early detec…

This study looks at why blood clots form in the legs (venous thrombosis) and lungs (pulmonary embolism) in over 21,000 African American and white adults. Researchers are using data from two long-running health studies to find risk factors. The goal is to better understand these c…

This study follows 2,000 adults aged 45-75 in Pennsylvania to better predict who is at risk for heart disease and why some groups are more affected than others. About 800 participants at higher risk will be randomly assigned to either usual care or a special lifestyle program to …

This study looks at heart MRI scans from 10,000 adults to see how well these images can predict future heart problems, like heart failure or death. Researchers will track participants over time to link scan findings with health outcomes. The goal is to improve how doctors use MRI…

This study follows over 4,000 women for years after their first pregnancy to understand how pregnancy-related health issues (like high blood pressure or diabetes) are linked to future heart disease. Researchers will track conditions such as high blood pressure, diabetes, and obes…

This study looks at how being in the intensive care unit (ICU) after heart surgery affects patients' sleep and internal body clocks. Researchers will track sleep depth and thinking skills in 15 adults who own an Apple smartphone. The goal is to understand how hospital routines di…

This study watches over 800 heart failure patients in Germany who are starting dapagliflozin, a drug recently approved for heart failure. Researchers will track how long patients stay on the drug, any side effects, and changes in symptoms and quality of life. The goal is to see h…

This study tests whether using large health databases can help more people take cholesterol-lowering statins to prevent heart attacks and strokes. Researchers are working with 500,000 people in high-risk Ontario communities to see if educational tools for patients and doctors imp…

This study tests a program called CONNECT that helps women and Black/Latino adults learn about and join heart health research. About 1,000 adults with heart disease or risk factors like high blood pressure or diabetes will receive text messages with health info and study opportun…

This study looks at how serious combat injuries impact the long-term health of US military members. Researchers will measure heart activity, blood pressure, sleep patterns, and mental health in 200 injured service members. The goal is to understand links between injury severity, …

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …

This study follows over 5,000 Black and White adults from age 18-30 for decades to see how their lifestyle and health changes affect heart disease risk later in life. Researchers measure things like blood pressure, weight, and cholesterol over time. The goal is to understand what…

This study watches 2000 people in China who get a SYNERGY stent to open blocked heart arteries. Researchers want to see how often major heart problems happen after the procedure. It is not testing a new treatment, just checking how well the approved device works in everyday medic…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor can also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. However, the study was withdrawn before enr…

This long-term study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related disabilities. Researchers used medical records and exams to identify risks and triggers. The goal was to better understand how to prevent these con…

This study looks at how a specific gene (PDE3B) affects fat tissue and the body's handling of sugar and fats. Researchers will compare two groups of 40 adults—some with a natural gene variant and some without—using detailed metabolic tests. The goal is to understand if targeting …

This study will follow 10,000 Italian adults with COPD to learn more about the disease's impact, including how often flare-ups happen, what other health problems occur, and how many patients die each year. Researchers will collect information from medical records and routine chec…

This study will give 300 new mothers a medical-grade smartwatch to continuously monitor their blood pressure for 6 weeks after delivery. Researchers want to see how blood pressure changes differ between low-risk, intermediate-risk, and high-risk women. The goal is to learn how to…

This study aimed to understand how often people with diabetes have high calcium buildup in their heart arteries, and how doctors currently manage this finding. It planned to enroll adults with type 1 or type 2 diabetes who had no heart symptoms. The study was withdrawn before any…

This study collects blood samples and medical information from nearly 10,000 people who have had heart catheterization or CT scans. The goal is to create a gene bank that researchers can use to study what causes coronary artery disease. Participants provide a blood sample and ans…

This study follows people who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring, cancer, or liver failure. About 121 adults will be monitored for up to 10 years with regular tests, scans, and questionnaires. The goal is …

This study looks at different ways to give people their genetic test results. Researchers want to see if using a website or chatbot is as good as talking to a genetic counselor by phone or video. About 2,500 adults from a biobank who have certain genetic changes linked to cancer …

This study follows 347 heart surgery patients to find out why some develop swallowing problems (dysphagia) and how to spot them early. Researchers will create simple tools to predict risk and detect signs at the bedside. The goal is to improve care and prevent complications after…

This study tests whether a smartphone app called PulsePoint can increase the number of people who receive CPR or a defibrillator from a bystander before emergency services arrive. About 340 adults who suffer a sudden cardiac arrest in a public place will be included. Half of the …

This study tests a new imaging method called OCT-NIRAF to see if it can predict how plaque builds up in heart arteries. About 40 adults with heart disease will get this special scan during a standard heart procedure, then a CT scan a year later. The goal is to learn if the new sc…

This study watches 200 men with prostate cancer who are getting hormone therapy (androgen deprivation therapy) to see how it affects their heart health. Researchers will use heart ultrasounds, blood tests, and surveys to track changes and look at how factors like race, income, an…

This study was planned to see if nitric oxide could help blood vessels work better in heart surgery patients with pre-existing blood vessel problems. It was an add-on to a larger trial and would have measured blood flow in the arm. However, the study was withdrawn before enrollin…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. It involves 20 VA sites across 4 regions, testing two different support strategies. The goal is to see which approach gets more women …

This study looks at whether fluid from the skin can be used to find early signs of heart disease. Researchers will collect skin fluid and blood from 30 people—some with chronic heart failure and some healthy young adults—to see if certain markers are present. The goal is to devel…

This long-term study followed over 6,400 adults from different racial and ethnic backgrounds to learn how early signs of heart disease develop and lead to serious events like heart attacks or strokes. Participants were healthy at the start and were monitored for years through exa…

This study follows over 5,000 people with stable heart disease for up to 10 years to compare two treatment approaches: an early invasive strategy (procedures like stents or bypass) plus medications, versus medications alone. Researchers want to see if one strategy leads to fewer …

This study looks at whether people with POTS (a condition causing a rapid heart rate upon standing) have higher levels of certain immune proteins that might attack their own nervous system. Researchers will measure these proteins in blood samples from 58 participants, including b…

This study looks at why Black people with HIV are more likely to develop kidney disease, diabetes, and heart problems. Researchers are analyzing genetic and health data from over 3,000 participants to find risk factors. The goal is to better understand these diseases and improve …

This study looks at how daily experiences like stress and racial discrimination affect heart health in Black women aged 18-49. Researchers will monitor physical activity, sleep, and blood vessel function using wearable devices and lab tests. The goal is to understand what factors…

This study follows 2,314 South Asian adults (ages 40-84) in the US to uncover why they have high rates of heart disease and stroke, even without typical risk factors. Researchers measure artery calcium, diabetes, and other markers over time. The goal is to identify unique causes …

This study tests whether giving doctors a special risk score—one that combines a person's genes with things like cholesterol and age—helps them make better decisions to prevent heart disease. About 1,000 people at moderate risk for heart disease but who have never had a heart att…

This study looks at 100 adults with sleep bruxism (teeth grinding during sleep) to understand how it relates to sleep quality, heart health, thyroid function, and mental well-being. Participants will undergo sleep monitoring and fill out questionnaires. No treatment is given; the…

This study follows over 6,000 people over many years to see if traits like hostility and other emotional factors are linked to heart disease. Researchers are observing participants without giving any treatment. The goal is to better understand what leads to heart problems, not to…

This study looks at whether a telehealth system can help rural patients with heart problems get better care. It connects local emergency teams and clinics with heart specialists at a larger medical center. About 215 adults with heart symptoms will take part. The goal is to see if…

This study looks at how two specific genes, SWAP70 and GMPR, may influence the risk of heart disease. Researchers will analyze blood samples from 100 healthy volunteers who have already had their genes mapped. The goal is to better understand the biological processes behind heart…

This study is a first step toward creating a heart disease risk score designed specifically for women. Researchers will follow 176 women aged 25-55 who have had conditions like pre-eclampsia, gestational diabetes, or early menopause, which can raise heart risk. The goal is to bet…

This study was designed to see if giving nitric oxide gas during heart surgery changes levels of certain molecules linked to oxidative stress. It was an add-on to a larger trial and planned to include adults having elective heart surgery. However, the study was withdrawn before e…

This study looks at whether training peer coaches can help patients with limited health literacy talk to their doctors about preventing heart disease. About 60 adults at risk for heart disease will work with a peer coach before a doctor visit. The goal is to see if this approach …