Pedal power: could stationary bike workouts protect hearts of young cancer survivors?

NCT ID NCT07442578

Symptom relief Sponsor: Dana-Farber Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether different levels of exercise can improve heart health in young adults who survived childhood cancer and were treated with a type of chemotherapy called anthracyclines, which can weaken the heart. Twenty survivors aged 18 to 39 will do either high-intensity or moderate-intensity stationary bike workouts at home via Zoom. Researchers will measure changes in heart function and fitness to see which exercise intensity works best.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: exercise program (stationary bike via Zoom)
What this could lead to: If successful, this could show that specific exercise programs help protect or improve heart function in young adult cancer survivors.
What could go wrong: This is a very small early trial with only 20 participants, so results may not apply to everyone. Exercise programs require ongoing commitment and may not be suitable for all survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 39 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Current age at study initiation 18-39 years. * Cancer diagnosis at age ≤ 18 years. * Previous exposure to any dose of anthracyclines. * Are ≥2 years post-treatment and in remission without relapse after cancer directed therapy. * Eastern Cooperative Oncology Group Performance Status = 0 * Oncology survivorship provider clearance to participate in exercise * No self-reported comorbidities or contraindications that prohibit the undertaking of high intensity exercise (e.g., severe valvular heart disease) * Sedentary (i.e., currently participates in ≤ 60 minutes of structured high or moderate intensity exercise/week) determined by self-report during screening using the Godin Leisure Time Exercise Questionnaire * Speak English * Willing to travel to Dana-Farber Cancer Institute for necessary data collection Exclusion Criteria: * Unstable comorbidities that prevent participation in moderate-to-vigorous intensity exercise. * Patients who are pregnant. * Participate in more than 60 minutes of structured moderate-to-vigorous exercise per week over the last month. * Patients receiving treatment for other active malignancies (except basal cell carcinoma). * Subjects who in the opinion of the investigators, may not be able to comply with the safety monitoring requirements of the study. * Unable to travel to DFCI Longwood campus for necessary data collection.

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Conditions

The condition(s) this trial relates to.

cardiomyopathy due to anthracyclines Cardiotoxicity cardiovascular disorder childhood malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anthracycline induced cardiotoxicity Cardiotoxicity Cardiovascular diseases Childhood cancer survivors

Pedal power: could stationary bike workouts protect hearts of young cancer survivors?

What the study statuses mean