Dana-farber Cancer Institute

This study tests whether giving a precise, high-dose radiation treatment (SBRT) early can slow the growth of adenoid cystic carcinoma that has spread to a few spots in the body. About 32 adults with 1 to 5 metastatic lesions will receive SBRT to all visible tumors. Researchers wi…

This study looks at whether giving a lower dose of radiation (and sometimes less chemotherapy) after surgery can still keep HPV-related throat cancer from coming back, while causing fewer side effects. About 111 adults who have had surgery for this cancer will take part. The goal…

This study tests a drug called pemigatinib in people with a rare type of advanced stomach cancer (SDH-deficient GIST) that cannot be removed by surgery. The goal is to see if the drug can shrink tumors and control the disease. About 24 adults will take part, and researchers will …

This study tests whether specially trained natural killer (NK) cells can help prevent acute myeloid leukemia, myelodysplastic syndrome, or related blood cancers from coming back after a stem cell transplant. About 15 adults at high risk of relapse will receive an infusion of thes…

This study tests whether adding pembrolizumab to sacituzumab govitecan helps control advanced triple-negative breast cancer that is PD-L1-negative. About 110 adults with metastatic disease will receive either the combination or sacituzumab alone. The goal is to see which approach…

This study tests whether combining two targeted drugs, zanubrutinib and venetoclax, can make CLL or SLL undetectable in people whose cancer returned after prior treatment. About 45 adults who have not used these specific drugs before will take both pills daily. The main goal is t…

This study tests two antibody-drug conjugates (sacituzumab govitecan and enfortumab vedotin) with or without the immunotherapy pembrolizumab in people with metastatic urothelial cancer (bladder cancer that has spread). The first phase finds the safest dose, and the second phase c…

This study tests a drug called belumosudil in people who have developed a serious lung condition (bronchiolitis obliterans syndrome) after a stem cell transplant. The goal is to see if the drug can improve lung function or slow the disease. About 45 participants will receive the …

This early-phase study tests a new therapy using specially trained natural killer (NK) cells to fight recurrent ovarian cancer that no longer responds to platinum chemotherapy. About 18 participants will receive the cell therapy along with interleukin-2 to boost activity. The mai…

This study tests a drug called abemaciclib in people with advanced solid tumors that have certain genetic changes (in CCND1, CCND2, CCND3, CDK4, or CDK6). The goal is to see if the drug can stop or slow the cancer from growing. About 38 participants will receive the drug, and res…

This study tests whether a 16-week, culturally tailored exercise program (aerobic and resistance training) can lower heart disease risk in Black men with prostate cancer who are receiving hormone therapy (androgen deprivation therapy). About 62 participants will be randomly assig…

This study tests whether adding the targeted drug T-DM1 to standard chemoradiation can prevent cancer from returning in people with HER2-positive salivary gland cancer. About 37 adults with advanced but removable tumors will receive the combination and be followed for 2 years. Th…

This study tests a combination of three drugs (pembrolizumab, ibrutinib, and rituximab) in people whose primary central nervous system lymphoma has come back or not responded to prior treatment. The goal is to see if the combination can stop the cancer from growing for at least 6…

This study tests a program called CHEF that helps childhood cancer survivors and their families cook and eat healthier foods. The goal is to improve diet quality and support long-term heart health. About 17 children who have finished cancer treatment will take part for 6 months.

This early-phase study tests whether a new immune cell therapy, called memory-like natural killer (NK) cells, can be safely given to people with advanced kidney or bladder cancers. The NK cells are taken from the patient's blood, treated with special proteins to boost their cance…

This study tests whether giving two drugs—ficerafusp alfa and pembrolizumab—before surgery can shrink tumors in people with advanced head and neck cancer. About 32 participants with resectable, PD-L1-positive tumors will receive the combination, then have surgery. The main goal i…

This early-phase trial tests a new treatment for people whose leukemia or related blood cancers return after a stem cell transplant. The therapy uses specially trained natural killer (NK) cells from a donor, followed by low-dose IL-2 to help them work. The main goal is to find th…

This study tests whether the drug belzutifan can shrink or slow the growth of clear cell cancers of the ovary, uterus, cervix, vagina, or vulva that have come back or not gone away. About 32 adults with these rare cancers will receive belzutifan pills. The goal is to see how many…

This early-phase study tests a drug called SL-401 combined with other medicines (azacitidine and venetoclax) in people with certain blood cancers (AML, MDS, or BPDCN) that have come back or are hard to treat. The main goal is to find the safest dose and see if the combination hel…

This study tests a new blood test that looks for DNA from lung cancer cells in people who are at higher risk but cannot get standard screening. It includes 1,000 healthy Asian and Latinx adults aged 50–80 who do not currently smoke. The goal is to see how well the test finds earl…

This study is testing a blood test called Galleri that looks for signs of many types of cancer early. It involves 1,500 veterans who served on active duty for at least four years and are 45 or older. The goal is to see if this test can find cancers sooner than standard methods.

This study looks at whether a supervised exercise program can reduce breast cancer risk in women with dense breast tissue. Researchers will measure changes in blood and breast tissue markers before and after the exercise program. The study involves 46 women who are inactive and h…

This study tests a light therapy device (like a lollipop) placed inside the mouth to prevent severe mouth sores in patients receiving a stem cell transplant. The sores are a common and painful side effect of the transplant conditioning. Twenty adults will receive daily light trea…

This study looks at whether a 6-month home exercise and nutrition program can improve thinking and physical abilities in cancer survivors aged 65 and older, along with their support person. About 1,500 participants will either follow a virtually supervised or an unsupervised prog…

This study looks at whether a 16-week virtual exercise program (aerobic and strength training) can help women with ovarian or endometrial cancer who are on chemotherapy after surgery. The goal is to see if it improves leg function and reduces numbness or tingling in hands and fee…

This study looks at whether a home-based resistance exercise program combined with protein supplements can help people with pancreatic cancer maintain muscle mass while on chemotherapy. About 45 participants will be split into three groups: exercise plus protein, exercise only, o…

This study tests a program called BOLSTER designed to help patients with advanced gynecologic or gastrointestinal cancers and their caregivers manage complex care needs. About 600 participants will be enrolled to see if the program improves quality of life and well-being. The goa…

This study is testing an online program called On-Trac (Online Training After Cancer) to help adult cancer survivors learn strategies to manage anxiety. The program uses techniques from cognitive-behavioral therapy and acceptance commitment therapy. Researchers will enroll 80 par…

This study is testing a communication tool called CASI for people with advanced ovarian cancer, their caregivers, and doctors. The tool helps everyone agree on what to discuss during medical visits. The goal is to see if this approach is practical and helpful for improving care.

This study tests whether an 8-week home exercise program, done before a stem cell transplant, can improve muscle strength and physical fitness in people with multiple myeloma. Thirty participants will either exercise or continue normal activities. The goal is to see if prehabilit…

This study tests a counseling and education program designed to help Chinese and Korean American smokers quit smoking and get screened for lung cancer. About 50 participants will receive the program and be followed for 6 months to see if they stop smoking. The goal is to improve …

This study tests whether a 16-week virtual high-intensity interval training (HIIT) program can improve physical fitness, thinking skills, and emotional well-being in young adults (ages 18-45) who survived a childhood brain tumor. Participants exercise from home using video guidan…

This study looks at whether adding a special support program (called RISE) to usual care can reduce financial and material hardships for low-income families whose children are being treated for high-risk neuroblastoma. About 84 children and their parents will take part, with some…

This study tests a 6-session therapy program called Acceptance & Commitment Therapy (ACT) for cancer patients who are at risk of misusing opioids. The goal is to see if the program is practical and helpful for managing psychological symptoms like difficult thoughts and emotions. …

This study tests whether a special cooling cap (Paxman Scalp Cooling System) can reduce hair loss in people with metastatic breast cancer who are receiving certain chemotherapy drugs. About 120 participants will be randomly assigned to use the cooling cap or not. The goal is to s…

This study looks at whether a 16-week supervised exercise program (combining strength training and aerobic exercise) can improve frailty and muscle loss in men with metastatic prostate cancer who are on hormone therapy. The study will enroll 80 men who are already frail or pre-fr…

This study tests whether a 16-week high-intensity interval training (HIIT) program can help women with breast cancer keep their thinking skills sharp during chemotherapy. Thirty women newly diagnosed with stage I-III breast cancer will participate. The goal is to see if exercise …

This study tests a program called UPLYFT for lymphoma survivors who worry about their cancer returning. About 74 survivors who finished treatment 3 to 24 months ago will take part. The program provides information and tools to improve quality of life and reduce cancer-related wor…

This study looks at whether a 12-week exercise program can help people with advanced lung cancer who are receiving immunotherapy. Researchers will test different exercise intensities to see if they are safe and helpful. The goal is to improve treatment outcomes and quality of lif…

This study looks at whether adding a geriatrician (a doctor who specializes in care for older adults) to the cancer care team helps people aged 70 and older with gastrointestinal cancers. Researchers want to see if this approach is practical and if it reduces unplanned hospital v…

This study is for women aged 80 and older who have had breast cancer but are currently cancer-free. It tests a shared decision-making toolkit to help them and their doctors decide whether to continue getting yearly mammograms. The goal is to see if the toolkit leads to more infor…

This study enrolls 30,000 people at higher risk for multiple myeloma, including African Americans and those with a family history of blood cancers. Participants are monitored over time to see who develops the disease and why. The goal is to find better ways to predict and eventua…

This study aims to find genetic changes that cause early blood conditions to turn into cancer. Researchers will collect blood, bone marrow, or cheek swab samples from up to 10,000 people who have or are at risk for certain blood cancers. The goal is to better understand how these…

This study collects blood or tissue samples and medical information from 2750 people with chronic lymphocytic leukemia (CLL) or related conditions. Researchers will use these samples to explore the causes and biology of CLL, including new genetic markers. Participants are seen at…

This study collects medical information and samples from 1,500 people with TP53 gene changes (linked to Li-Fraumeni Syndrome, a condition that raises cancer risk) and their relatives. Researchers aim to better understand how these gene variants affect cancer risk and family histo…

This study is testing whether a blood test (liquid biopsy) can help doctors predict the future course of Ewing sarcoma and osteosarcoma in children and young adults. Researchers will look for tumor DNA in the blood at diagnosis and see if it relates to how well patients do over t…

This study collects tissue samples from 240 adults with malignant pleural mesothelioma to test a new method that combines molecular, radiological, and blood tests to predict how the disease will progress. The goal is to help doctors better determine each patient's prognosis and t…

This study is testing a new online platform called Nest for young adults aged 18-39 who have had genetic testing for cancer risk. The platform gives patients and their doctors access to updated information about genetic findings, including uncertain results. The goal is to see if…