Vitamin D's secret power against colon cancer? early trial tests genetic effects
NCT ID NCT02172651
First seen May 20, 2026 · Last updated Jun 19, 2026 · Updated 4 times
Summary
This early-phase trial is looking at how vitamin D affects colon cancer at the genetic level. About 80 people with stage I-III colon cancer or resectable liver metastases will take either high-dose vitamin D or a placebo for 14-28 days before their scheduled surgery. Researchers will then analyze the tumor tissue to see if vitamin D changes which genes are turned on or off, especially those related to the vitamin D receptor. The goal is not to treat the cancer directly, but to understand the biological pathways involved.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-••••
Locations
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02115, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vitamin D3 (cholecalciferol)
What this could lead to
If successful, this study could reveal how vitamin D works at the genetic level in colon cancer, potentially guiding future treatments that use vitamin D to slow or stop cancer growth.
What could go wrong
This is a very early, small study focused on biological markers, not on curing or treating cancer directly. It may not show any clear benefit, and high-dose vitamin D can cause side effects like high calcium levels.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.