Dana-farber Cancer Institute

This phase 2 trial is testing a drug called FHD-286 in 20 people with a specific type of small-cell lung cancer that has a marker called POU2F3. Participants must have already tried at least one standard chemotherapy. The drug is taken as a capsule daily in 21-day cycles, and res…

This phase 4 trial tests the drug cosibelimab in 80 people with advanced cutaneous squamous cell carcinoma who also have a kidney transplant or a blood cancer. The goal is to see if the drug can shrink tumors and how safe it is in these groups. Cosibelimab works by helping the im…

This Phase 3 trial is testing a personalized approach for people with newly diagnosed multiple myeloma who are eligible for a stem cell transplant. After initial treatment with a four-drug combination (isatuximab, iberdomide, bortezomib, and dexamethasone), the next steps—consoli…

This study tests a combination of four drugs (isatuximab, iberdomide, bortezomib, and dexamethasone) in 88 adults newly diagnosed with multiple myeloma who cannot or choose not to have a stem cell transplant. The goal is to find the safest dose and see how well the drugs control …

This study is for adolescents and young adults (ages not specified) with newly diagnosed Philadelphia chromosome-negative acute lymphoblastic leukemia (ALL). Researchers want to see if a specific combination of chemotherapy drugs plus the immunotherapy blinatumomab helps more pat…

This study tests a program to help women with ER-positive breast cancer in Rwanda take their daily hormone therapy as prescribed. The program includes education, reminders, and behavioral support. Researchers will measure how well participants stick with their medication and how …

This study tests whether a blood test that tracks HPV DNA can help doctors choose the right amount of treatment for people with HPV-positive throat cancer. About 116 participants with early-stage cancer will receive therapy tailored to their risk level, aiming to improve survival…

This study will test a blood test called GRAIL Galleri that looks for signs of many different cancers at once. Researchers will give the test to 100 adults who have symptoms that might be cancer and are already being checked by doctors. They want to see how well the test finds ca…

This study tests whether low doses of two hormone-blocking drugs, exemestane and tamoxifen, can help prevent breast cancer in postmenopausal women at high risk. About 140 women will take one of the two drugs for a year, and researchers will measure side effects and quality of lif…

This pilot study tests whether a personalized exercise program is practical for 20 adults with stage II or III non-small cell lung cancer who are about to start treatment. Participants will follow the Precise Exercise Regimen for Cancer Care (PERCC) program before and after their…

This study tests whether adding acupuncture to virtual exercise can help manage nerve pain caused by a specific bladder cancer treatment (EV-Pembro). About 50 adults with advanced bladder cancer will be split into two groups: one gets acupuncture plus virtual exercise, the other …

This study is testing a smartphone app called I-STAMP that helps people with advanced cancer keep track of their pain and medications. About 73 participants will use the app and rate how easy it is to use and how helpful it is. The goal is to see if the app can make managing canc…

This study tests a new educational program called SHARE-MC for women with metastatic breast cancer who are bothered by sexual problems. The program aims to improve sexual function and reduce emotional distress. About 96 women will take part online. The goal is to see if this prog…

This study is testing a mobile app called my.naviGATE for teens and young adults (ages 15-24) who have finished cancer treatment. The app provides personalized education, peer support, and tracks how patients are doing. Researchers want to see if the app helps patients feel more …

This study is testing a new web and mobile app called SHIELD, designed to support women with hormone receptor-positive breast cancer who are on long-term hormone therapy. The goal is to see if the app is easy to use and helpful for managing treatment. About 30 women will particip…

This study is building an AI tool called ACTIVATE that scans electronic health records to find cancer patients who may be eligible for clinical trials. Researchers will test whether sending alerts to doctors increases the number of patients starting trials. The goal is to make it…

This study aims to create a nutrition algorithm called NACHO to help cancer patients improve their nutritional status and quality of life during or after treatment. Researchers will gather data from 130 participants, including patients, dietitians, and advisors, to build and test…