Heart disease study aims to unlock genetic secrets of dilated cardiomyopathy

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

PART 1 Inclusion Criteria: * Male or female participants of any age * Capacity to provide informed consent * Patients with a confirmed diagnosis of DCM * Affected family members of patients meeting diagnostic criteria for DCM Exclusion Criteria: * DCM attributed to chemotoxicity (from chemotherapeutic agents, drugs of abuse) * DCM attributed to systemic inflammatory myopathies (eg sarcoid, systemic lupus erythematosus) * Patients who lack capacity to consent for themselves * Patients with a confirmed history of coronary artery disease, assessed using standard UK clinical practice guidelines, defined as one or more of the following:- * \>50% narrowing, any major epicardial coronary artery on invasive or computed tomography coronary angiography * CMR suggestive of previous myocardial infarction of ≥2 segments of ≥50% infarction of the LV wall * Previous percutaneous coronary intervention or coronary bypass surgery * History of primary valvular heart disease or congenital heart disease * Severe, untreated or untreatable hypertension (systolic blood pressures routinely \>180 mm Hg and/or diastolic blood pressures \>120 mm Hg) PART 2 Inclusion Criteria: * Males or females of any age * Capacity to provide informed consent * Patients with hypokinetic non-dilated cardiomyopathy, or * Family members of DCM patients with possible or probable DCM or * Patients with a confirmed diagnosis of heritable cardiovascular disease or * Family members of patients with heritable cardiovascular disease, both affected and unaffected Exclusion Criteria: * Patients who lack capacity to consent for themselves * Patients with a confirmed history of coronary artery disease, assessed using standard UK clinical practice guidelines, defined as one or more of the following:- * \>50% narrowing, any major epicardial coronary artery on invasive or computed tomography coronary angiography * CMR suggestive of previous myocardial infarction of ≥2 segments of ≥50% infarction of the LV wall * Previous percutaneous coronary intervention or coronary bypass surgery * History of primary valvular heart disease or congenital heart disease * Severe, untreated or untreatable hypertension (systolic blood pressures routinely \>180 mm Hg and/or diastolic blood pressures \>120 mm Hg)