Imperial College London

This study compares two pacemaker methods for people with a slow heart rate: standard right ventricular pacing and a newer 'physiological pacing' that targets the heart's natural conduction system. Researchers will track 2,600 participants over time to see which method better pre…

This study tests whether cooling babies who had a mild lack of oxygen at birth can improve their brain development by age 2. About 426 full-term newborns will be randomly assigned to either whole-body cooling or normal temperature care. The goal is to see if cooling leads to bett…

This study aims to find out which type of specialist pacemaker works best for people with heart failure and a delay in how the heart's lower chambers beat together. Sixty participants will be randomly assigned to one of three pacing methods and followed for six months. Researcher…

This early-stage study tests whether taking a 5-day course of the drug ASTX727 before standard Lutathera radiation therapy can help the radiation target cancer cells more effectively. About 27 adults with metastatic neuroendocrine tumors will receive the combination. The goal is …

This study tests whether using remote monitoring devices after a heart valve procedure (TAVI) allows patients to safely go home the same day instead of staying in the hospital. 216 adults who are eligible for same-day discharge will be randomly assigned to either standard care or…

This study looks at whether using ultrasound to find fatty lumps (lipohypertrophy) caused by insulin injections can help people with diabetes improve their blood sugar levels. About 50 adults with type 1 or type 2 diabetes who use insulin and a continuous glucose monitor will get…

This study looks at whether an automated insulin delivery system (the Medtronic 780G) can help adults with diabetes and advanced kidney disease manage their blood sugar better than their usual insulin injections. Participants will use the system for 8 weeks and then switch to the…

This study tests whether artificial intelligence can plan cardiac MRI scans as accurately as expert radiographers. 150 adults will receive both an AI-planned and a standard scan, and doctors will compare the image quality and time taken. If successful, AI could help reduce long w…

This study is testing a non-invasive breath test to detect pancreatic cancer earlier. Researchers will collect breath samples from over 6,000 people referred for possible pancreatic cancer. The test looks for tiny molecules made by cancer cells. If accurate, it could help doctors…

This study aims to develop a non-invasive breath test to detect pancreatic cancer earlier. Pancreatic cancer is often diagnosed late because early symptoms are vague. The test measures tiny molecules in breath that may signal cancer. Researchers will collect breath and urine samp…

This study tests a new type of MRI scanner that may give clearer pictures of knee ligaments and tendons. Standard MRIs often miss these tissues, but the new method (MADI) uses a special angle to capture them. Researchers will scan 20 adults scheduled for ligament repair to see if…

This study tests whether artificial intelligence (AI) can analyze routine heart tests (ECGs) to find hidden heart problems like weak heart muscle, valve issues, or high lung pressure. About 590 adults without a prior heart disease diagnosis will have ECGs taken with standard mach…

This study looks at whether the things people buy at stores—like pain relievers or digestive aids—could be early warning signs of cancer. Researchers will compare the shopping habits of 2900 people, some diagnosed with cancer and some not, to see if certain purchases happen more …

This study tests whether giving blood-thinning medicine after varicose vein surgery can prevent dangerous blood clots in the legs or lungs. About 1 in 50 people develop a clot after these procedures. The trial will enroll 3,175 adults and compare those who receive the medicine to…

This study looks at whether wearing compression stockings in the hospital, on top of taking blood-thinning medication, can further reduce the risk of dangerous blood clots after surgery. About 8,600 adults having high-risk operations (like cancer or joint surgery) will be randoml…

This study tests a wearable belt that tracks muscle activity and gives real-time feedback through a phone app during core exercises. About 40 adults with long-term lower back pain will either use the belt plus standard care or standard care alone for 8 weeks. Researchers want to …

This study is building a large global database of people with familial hypercholesterolemia (FH), a genetic condition causing very high cholesterol and early heart disease. Researchers will analyze data from over 60,000 participants across nearly 60 countries to better understand…

This UK study follows 90 families of very premature babies (born before 30 weeks) for one year after hospital discharge. It measures how a serious bowel condition called NEC affects the baby's health, family finances, and emotional wellbeing. Parents fill out questionnaires at th…

This study, called ORBITA-SOLAR, aims to find out if different narrowed arteries in the heart cause chest pain (angina) at different levels of blood flow reduction. Sixty people with stable angina who need stents will have a tiny balloon inflated inside each stent while they exer…

This study aims to compare how the immune system responds to a flu nasal spray vaccine versus a controlled infection with a specific flu virus (H3N2). Thirty-six healthy adults aged 18-55 will either receive the vaccine or be deliberately infected with the virus. Researchers will…

This early-phase study at Imperial College London is testing whether a low, non-hallucinogenic dose of psilocybin (the active ingredient in magic mushrooms) can make a mental imagery therapy more effective for young people aged 16-25 who self-harm. The therapy, called Imagery Re-…

This observational study at Imperial College London will enroll 70 people undergoing heart catheterization to understand why some patients tolerate ventricular tachycardia (VT) better than others. Researchers will measure blood pressure and blood flow in the heart during simulate…

This study compares regular MRI scans to standard care for men with low-to-medium risk prostate cancer who are on active surveillance (watchful waiting). Over 5 years, researchers will see if MRIs catch cancer progression earlier and reduce the need for biopsies and clinic visits…

This study looks at how the body processes high doses of the steroid prednisolone in people with inflammatory diseases like thyroid eye disease, asthma, and vasculitis. Researchers will measure steroid levels in the blood over time to compare short-term and long-term use. The goa…

This study follows 600 volunteers over age 65 for up to 3 years to understand how memory and thinking change as Alzheimer's disease develops. Researchers collect health information, thinking tests, and blood samples to find early warning signs. The goal is to improve detection an…

This study collects information from medical records of babies born at exactly 22 weeks of pregnancy across about 45 UK hospitals. The goal is to understand what happens to these extremely premature infants, what problems they face, and how they respond to intensive care. No chan…

This study looks at why people with COPD get very sick from a common cold virus (rhinovirus). Researchers will infect 50 volunteers—some with COPD, some healthy—in a controlled setting. They will compare lung and body responses to find new ways to prevent or treat COPD flare-ups.…

This study creates an online registry for 10,000 adults with cardiomyopathy or myocarditis (heart muscle diseases). Researchers will track health events like heart failure, arrhythmias, and death over time to better understand these conditions. Participants join from home and are…

This study looks at 100 older adults with normal pressure hydrocephalus (NPH) to find out why some get better after a shunt surgery and others do not. Researchers will use brain scans, blood tests, and wearable monitors to check for nerve damage and signs of dementia. The goal is…