Imperial College London

This study tested whether MitoQ, a supplement that targets cell energy centers, can improve heart function in people with dilated cardiomyopathy (a weakened, enlarged heart). 53 adults with the condition took MitoQ or a placebo for 3 months. Researchers measured heart energy leve…

This study tested a decision support system (DSS) that helps doctors choose the best cholesterol-lowering drugs for patients who recently had a heart attack. Over 1,100 adults from hospitals were involved, with some hospitals using the DSS and others providing standard care. The …

This study tested two drugs, ruxolitinib and fostamatinib, in 185 hospitalized adults with mild to moderate COVID-19 pneumonia. The goal was to see if either drug could prevent the disease from becoming severe, such as needing a ventilator or dying. Patients took the drug for 14 …

This study tested a treatment called TheraSphere for people with neuroendocrine tumors that have spread to the liver and cannot be removed by surgery. TheraSphere delivers tiny radioactive beads directly to the liver to kill cancer cells. The goal was to see if this approach coul…

This study tested a drug called axitinib against a placebo in 52 people with advanced colorectal cancer that had spread to the liver and stopped responding to chemotherapy. The goal was to see if axitinib could help control the cancer and to test a special ultrasound technique th…

This study tested the immunotherapy drug pembrolizumab in 35 adults with cancer of unknown primary (CUP), a cancer that starts in an unknown location. Participants received the drug intravenously, and researchers measured how many saw their tumors shrink or disappear. The goal wa…

This early-phase study tested a drug called itacitinib in 19 adults with advanced liver cancer that had not responded to first-line treatment. The goal was to check the drug's safety and see if it could shrink tumors or slow cancer growth. Itacitinib works by blocking a protein t…

This study looked at whether a breath test could help detect liver fibrosis, cirrhosis, or liver cancer. Researchers collected breath samples from 56 patients with known or suspected liver disease and analyzed them for specific chemical markers. The goal was to see if the test co…

This study tested whether advanced ultrasound techniques can predict if a surgically created blood vessel connection (arteriovenous fistula or AVF) will work for dialysis in people with end-stage kidney disease. Researchers measured artery stiffness and function in 76 patients be…

This study tested how well simple bedside exams (like listening to blood flow with a handheld Doppler or measuring ankle blood pressure) can detect poor leg circulation in people with diabetes. Over 600 adults with diabetes took part. The goal was to find the best way to spot cir…

This study looked at whether a simple ultrasound scan can help doctors diagnose May-Thurner Syndrome, a condition where a vein in the pelvis is compressed, causing left leg swelling. 40 adults with unexplained left leg swelling had ultrasound scans by three different specialists,…

This study looked at whether giving the Gardasil 9 HPV vaccine to women at the same time as surgery for abnormal cervical cells (CIN) can help clear the virus and prevent future infections. About 1,100 women aged 18-55 took part. The goal was to see if the vaccine reduces the cha…

This completed study tested whether semaglutide, a drug used for diabetes, could reduce inflammation in 18 people who had a blood clot in their lungs (pulmonary embolism). Researchers measured changes in blood markers of inflammation over 4 weeks. The goal was to see if the drug …

This study tested a nurse-led program called Palliate that trains family carers to prepare and give extra medications to loved ones dying at home. 30 adults evaluated how acceptable, safe, and easy the program was. The goal is to improve comfort and support for families during en…

This study looked at how the immune system of healthy adults aged 65-75 responds to RSV, a common cause of chest infections. Researchers gave volunteers a mild RSV infection and took blood and nose samples to find immune markers linked to protection. The goal is to use these find…

This completed study tested whether taking L-arginine, a natural amino acid, could prevent blood vessel damage caused by the painkiller celecoxib. Forty-four healthy men took either celecoxib alone, celecoxib plus L-arginine, or placebos for one week. Researchers measured changes…

This study looked at how doctors in the UK currently diagnose and manage venous leg ulcers. Researchers surveyed 135 primary care doctors and vascular specialists to understand current practices and what guidelines are needed. The goal is to find the most effective and cost-effic…

This study surveyed 231 adults with Lynch syndrome, a genetic condition that raises bowel cancer risk, to find out how many follow the UK recommendation of a colonoscopy every two years. Researchers also asked about the main challenges people face in getting this check-up. The go…

This study looked at 3820 adults with cancer who also had COVID-19. Researchers collected routine medical data to describe symptoms and identify factors affecting survival. The goal was to learn more about how COVID-19 affects cancer patients, not to test a new treatment.

This study tested whether giving heart attack patients remote monitoring devices to use at home could reduce the need for hospital readmissions. 337 participants with high cardiovascular risk took part. The goal was to see if telemedicine could safely provide necessary diagnostic…

This study looked at how the immune system of older adults (ages 60-75) responds to RSV, a common respiratory virus. Researchers gave a controlled dose of the virus to 28 healthy volunteers to track their immune reactions and any side effects. The goal was to find better targets …

This study reviewed the medical records of 237 patients who had a single surgery to remove both their gallbladder and any gallstones stuck in the bile duct. Researchers compared how well the surgery worked before, during, and after the COVID-19 pandemic. The goal was to see if th…

This study looked at how aging affects the health of people with HIV who are over 50 years old. Researchers tracked 1,377 participants in England and Ireland to find common medical problems and how HIV medications work differently in older adults. The goal was to learn more so do…