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Computer tool helps doctors choose better heart meds after attack

NCT ID NCT05844566

Knowledge-focused Sponsor: Imperial College London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a computer-based decision support system (DSS) helps doctors start or intensify cholesterol-lowering treatments earlier in patients who have had a heart attack. Over 1,100 patients from multiple hospitals took part. The DSS provided risk estimates but did not recommend specific drugs. Researchers compared outcomes between hospitals using the DSS and those providing standard care alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Decision Support System (DSS) - a computer tool that shows risk estimates
What this could lead to
If successful, this tool could help doctors make quicker, more effective decisions about cholesterol-lowering treatments after a heart attack, potentially reducing future heart risks.
What could go wrong
This is a completed trial, but the tool only provides information—it doesn't guarantee better outcomes. Results may not apply to all hospitals or patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,139 people

The number who actually took part.

Started

Apr 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 79 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: Sites: * Manage ACS patients as defined by: Symptoms of myocardial ischemia with an unstable pattern, occurring at rest or with minimal exertion, within 72 hours of an unscheduled hospital admission due to presumed or proven obstructive coronary disease and at least one of the following: * Elevated cardiac biomarkers * Resting electrocardiographic changes consistent with ischemia or infarction, plus additional evidence of obstructive coronary disease from regional wall motion or perfusion abnormality, 70% or more epicardial coronary stenosis by angiography, or need for coronary revascularization procedure * Mange post ACS follow up care of patients including risk factor control * Ability to provide follow up information on patient care for a minimum of 16 weeks including blood tests * Willing/ able to access and undertake training for the DSS * Adequate internet connection at site and the ability to access the DSS * No restrictions on use of LLTs (within national guidelines/ reimbursement) * Ability to include all essential parameters and patient information for DSS input Participants: * Aged ≥18 to \< 80 years old * Provide written informed consent * Presenting to a study site with ACS as LLT naïve, monotherapy or combination therapy (defined as more than one LLT agent) * Willing to take lipid lowering treatments for the secondary prevention of cardiovascular disease * Attending the same study site (or same clinical team) for ACS follow up to ensure follow up data can be collected; or ensure that follow up data can be collected from other clinical institutions as part of the clinical pathway. Exclusion criteria: Sites: * Unable to capture/ provide data on patients with ACS during admission and follow up * Unable or unwilling to use lipid lowering treatments other than statins for ACS care Participants: * Unable to provide written informed consent * LDL-C measurement \< 1.8 mmol/L at admission

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Conditions

The condition(s) this trial relates to.

acute coronary syndrome Coronary Disease myocardial infarction Non-ST Elevated Myocardial Infarction ST-elevation myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute coronary syndrome Myocardial infarction

Contacts and locations

Locations

  • A.O.U Policlinico di Modena S.C. di Cardiologia

    Modena, 41124, Italy

  • A.O.U. Ospedali Riuniti U.O.C. Cardiologia e UTIC

    Foggia, 71122, Italy

  • AUSL di Bologna-Ospedale Maggiore

    Bologna, 40133, Italy

  • AUSL-IRCCS di Reggio Emilia

    Reggio Emilia, 42121, Italy

  • Azienda Ospedaliera Universitaria Gaetano Martino

    Messina, 98125, Italy

  • Azienda Ospedaliera di Rilievo Nazionale (A.O.R.N.) "Sant'Anna e San Sebastiano" di Caserta

    Caserta, 81100, Italy

  • Azienda Ospedaliero Universitaria Santa Maria della Misericordia

    Udine, 33100, Italy

  • Calderdale Royal Hospital

    Halifax, West Yorkshire, HX3 0PW, United Kingdom

  • Conquest Hospital

    Brighton, East Sussex, TN37 7PT, United Kingdom

  • Freeman Hospital

    Newcastle upon Tyne, Tyne and Wear, NE7 7DN, United Kingdom

  • Glan Glwyd Hospital

    Bodelwyddan, Denbighshire, LL18 5UJ, United Kingdom

  • Gregorio Marañón General University Hospital

    Madrid, 28007, Spain

  • Hammersmith Hospital

    London, W2 1NY, United Kingdom

  • Hospital Clínico Universitario Santiago de Compostela

    Santiago de Compostela, A Coruña, 15706, Spain

  • Hospital Clínico Universitario Virgen de la Arrixaca

    El Palmar, Murcia, 30120, Spain

  • Hospital HM Montepríncipe

    Boadilla del Monte, Madrid, 28660, Spain

  • Hospital Universitario Fundación Jiménez Díaz

    Madrid, 28040, Spain

  • Hospital Universitario La Luz Quiron

    Madrid, 28003, Spain

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario Reina Sofia

    Córdoba, 14004, Spain

  • Hospital Universitario Rey Juan Carlos

    Móstoles, Madrid, 28933, Spain

  • Hospital Universitario Virgen Macarena

    Seville, 41009, Spain

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 08025, Spain

  • IRCCS Policlinico San Donato

    Milan, 20097, Italy

  • IRCCS. A.O.U. Policlinico San Martino IST

    Genova, 16132, Italy

  • Kettering General Hospital

    Kettering, Northamptonshire, NN16 8UZ, United Kingdom

  • Luton and Dunstable University Hospital

    Luton, Bedfordshire, LU4 0DZ, United Kingdom

  • North Tyneside General Hospital

    North Shields, Tyne and Wear, NE29 8NH, United Kingdom

  • Ospedale Sandro Pertini - ASL Roma 2

    Roma, 00157, Italy

  • Ospedale di Cisanello - A.U.O.P. Azienda Ospedaliera Universitaria

    Pisa, 56124, Italy

  • Puerta de Hierro Majadahonda University Hospital

    Madrid, 28222, Spain

  • Royal Bournemouth Hospital

    Bournemouth, Dorset, BH7 7DW, United Kingdom

  • Royal United Hospital

    Bath, Somerset, BA1 3NG, United Kingdom

  • Russell's Hall Hospital

    Dudley, West Midlands, DY12HQ, United Kingdom

  • Sandwell General Hospital

    Birmingham, West Midlands, B71 4HJ, United Kingdom

  • Scunthorpe General Hospital

    Scunthorpe, North Lincolnshire, DN15 7BH, United Kingdom

  • Southern Health and Social Care Trust, Craigavon Area Hospital

    Portadown, Northen Ireland, BT63 5QQ, United Kingdom

  • Sunderland Royal Hospital

    Sunderland, Tyne and Wear, SR4 7TP, United Kingdom

  • University Hospital of A Coruña

    A Coruña, Coruña, 15006, Spain

  • Vall d'Hebron University Hospital

    Barcelona, 08035, Spain

  • Worcestershire Royal Hospital

    Worcester, Worcestershire, WR5 1DD, United Kingdom

  • Worthing Hospital

    Worthing, West Sussex, BN11 2DH, United Kingdom

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