Can the HPV vaccine stop cervical abnormalities from returning after surgery?
NCT ID NCT03979014
First seen Feb 01, 2026 · Last updated Jun 23, 2026 · Updated 17 times
Summary
This study looked at whether giving the Gardasil 9 HPV vaccine to women at the same time as surgery for abnormal cervical cells (CIN) can help clear the virus and prevent future infections. About 1,100 women aged 18-55 took part. The goal was to see if the vaccine reduces the chance of high-grade cervical changes coming back.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Frölunda Specialist Hospital Gynecology Clinic
Västra Frölunda, 421 37, Sweden
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Guy's and St Thomas' NHS Foundation Trust
London, England, SE1 9RT, United Kingdom
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Helsinki University Hospital
Helsinki, 00280, Finland
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Nottingham University Hospitals NHS Trust
Nottingham, England, NG5 1PB, United Kingdom
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Regionhälsan Masthugget Clinic of Obstetrics and Gynecology
Gothenburg, 413 27, Sweden
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Royal Preston Hospital - Lancashire Teaching Hospitals NHS Trust
Fulwood, Preston, PR2 9HT, United Kingdom
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Sahlgrenska University Hospital
Gothenburg, 413 45, Sweden
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St James's University Hospital, Leeds
Leeds, England, LS9 7TF, United Kingdom
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St Mary's Hospital - Imperial College Healthcare NHS Trust
London, SW7 2BT, United Kingdom
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St. Mary's Hospital - Manchester University NHS Foundation Trust
Manchester, England, M13 9WL, United Kingdom
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Tampere University Hospital
Tampere, 33520, Finland
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West Middlesex University Hospital
London, England, TW7 6AF, United Kingdom
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Whittington Health NHS Trust
Middlesex, England, N19 5NF, United Kingdom
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Gardasil 9 vaccine
What this could lead to
If it works, this could show that giving the HPV vaccine right after cervical surgery helps prevent the virus from coming back and lowers the risk of needing more treatment.
What could go wrong
This trial is completed but results are not yet widely reported, so we don't know if the vaccine made a real difference. Also, the vaccine only protects against 9 HPV types, so other types could still cause problems.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.