Can the HPV vaccine stop cervical abnormalities from returning after surgery?

NCT ID NCT03979014

Completed Prevention Sponsor: Imperial College London Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether giving the Gardasil 9 HPV vaccine to women at the same time as surgery for abnormal cervical cells (CIN) can help clear the virus and prevent future infections. About 1,100 women aged 18-55 took part. The goal was to see if the vaccine reduces the chance of high-grade cervical changes coming back.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Gardasil 9 vaccine
What this could lead to: If it works, this could show that giving the HPV vaccine right after cervical surgery helps prevent the virus from coming back and lowers the risk of needing more treatment.
What could go wrong: This trial is completed but results are not yet widely reported, so we don't know if the vaccine made a real difference. Also, the vaccine only protects against 9 HPV types, so other types could still cause problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adenocarcinoma in situ cervical intraepithelial neoplasia cervical intraepithelial neoplasia grade 2/3 neoplasm Uterine Cervical Neoplasms uterine cervix carcinoma in situ

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOPLASIA

Contacts and locations

Locations

Frölunda Specialist Hospital Gynecology Clinic

Västra Frölunda, 421 37, Sweden
Guy's and St Thomas' NHS Foundation Trust

London, England, SE1 9RT, United Kingdom
Helsinki University Hospital

Helsinki, 00280, Finland
Nottingham University Hospitals NHS Trust

Nottingham, England, NG5 1PB, United Kingdom
Regionhälsan Masthugget Clinic of Obstetrics and Gynecology

Gothenburg, 413 27, Sweden
Royal Preston Hospital - Lancashire Teaching Hospitals NHS Trust

Fulwood, Preston, PR2 9HT, United Kingdom
Sahlgrenska University Hospital

Gothenburg, 413 45, Sweden
St James's University Hospital, Leeds

Leeds, England, LS9 7TF, United Kingdom
St Mary's Hospital - Imperial College Healthcare NHS Trust

London, SW7 2BT, United Kingdom
St. Mary's Hospital - Manchester University NHS Foundation Trust

Manchester, England, M13 9WL, United Kingdom
Tampere University Hospital

Tampere, 33520, Finland
West Middlesex University Hospital

London, England, TW7 6AF, United Kingdom
Whittington Health NHS Trust

Middlesex, England, N19 5NF, United Kingdom

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