Imperial College London

This study tests whether using remote monitoring devices after a heart valve procedure (TAVI) allows patients to safely go home the same day instead of staying in the hospital. 216 adults who are eligible for same-day discharge will be randomly assigned to either standard care or…

This study looks at whether using ultrasound to find fatty lumps (lipohypertrophy) caused by insulin injections can help people with diabetes improve their blood sugar levels. About 50 adults with type 1 or type 2 diabetes who use insulin and a continuous glucose monitor will get…

This study tests if a newer pacing method (physiological pacing) is better than the standard method for people with a slow heart rate. About 2,600 adults who need a pacemaker will be randomly assigned to one of the two methods. The goal is to see which approach reduces the risk o…

This early-stage study tests whether giving a drug called ASTX727 before Lutathera can help the treatment work better in people with metastatic neuroendocrine tumors. The ASTX727 is taken by mouth for 5 days to try to make cancer cells more visible to Lutathera. About 27 adults w…

This study looks at whether an automated insulin delivery system (the Medtronic 780G) can help adults with diabetes and advanced kidney disease manage their blood sugar better than their usual insulin injections. Participants will use the system for 8 weeks and then switch to the…

This study tests three different pacemaker settings in 60 people with heart failure and a slow heartbeat. The goal is to see which type improves symptoms and reduces heart rhythm problems the most over six months. Participants will be randomly assigned to one of three pacing meth…

This study tests whether cooling the whole body of newborns who had a mild lack of oxygen at birth can improve their brain development by age 2. About 426 babies will be randomly assigned to either cooling (33.5°C) or normal temperature (37°C) for 72 hours. The goal is to see if …

This study is developing a non-invasive breath test to detect pancreatic cancer earlier. It will involve 1005 adults, including those with pancreatic cancer, diabetes, or non-specific symptoms. The test measures tiny molecules in breath that may signal cancer, helping doctors dec…

This study tests a new type of MRI scanner that may give clearer pictures of knee ligaments and tendons. Standard MRIs often miss these tissues, but the new method (MADI) uses a special angle to capture them. Researchers will scan 20 adults scheduled for ligament repair to see if…

This study tests whether artificial intelligence (AI) can analyze routine heart tests (ECGs) to find hidden heart problems like weak heart muscle, valve issues, or high lung pressure. About 590 adults without a prior heart disease diagnosis will have ECGs taken with standard mach…

This study is testing a new breath test to help detect pancreatic cancer earlier. Pancreatic cancer is hard to diagnose because its symptoms are similar to common illnesses. The test looks for tiny molecules in the breath that are made by cancer cells. Researchers will study abou…

This study looks at whether the things people buy at stores—like pain relievers or digestive aids—could be early warning signs of cancer. Researchers will compare the shopping habits of 2900 people, some diagnosed with cancer and some not, to see if certain purchases happen more …

This study tests whether giving blood-thinning medicine after varicose vein surgery can prevent dangerous blood clots in the legs or lungs. About 1 in 50 people develop a clot after these procedures. The trial will enroll 3,175 adults and compare those who receive the medicine to…

This study looks at whether wearing compression stockings in the hospital, on top of taking blood-thinning medication, can further reduce the risk of dangerous blood clots after surgery. About 8,600 adults having high-risk operations (like cancer or joint surgery) will be randoml…

This study tests a wearable belt that tracks muscle activity and gives real-time feedback through a phone app during core exercises. About 40 adults with long-term lower back pain will either use the belt plus standard care or standard care alone for 8 weeks. Researchers want to …

This study aims to understand how the immune system reacts to the flu virus compared to a flu vaccine. Healthy adults aged 18-55 will either receive a nasal spray flu vaccine or be exposed to a controlled dose of the flu virus. Researchers will track symptoms and immune markers t…

This study collects information from medical records of babies born at exactly 22 weeks of pregnancy across about 45 UK hospitals. The goal is to understand what happens to these extremely premature infants, what problems they face, and how they respond to intensive care. No chan…

This study gathers health information from 75,000 people with familial hypercholesterolemia (FH), a genetic condition causing very high cholesterol and early heart disease. Researchers aim to better understand how FH is diagnosed and treated worldwide. No new treatments are teste…

This study looks at how the body processes high doses of the steroid prednisolone in people with inflammatory conditions like thyroid eye disease, asthma, and vasculitis. Researchers will measure drug levels in the blood over time to compare short-term and long-term use. The goal…

This study follows 600 volunteers over age 65 for three years to understand how memory and thinking change as Alzheimer's disease develops. Researchers will collect health information, thinking tests, and blood samples to find early warning signs. The goal is to improve future de…

This observational study looks at why some people tolerate ventricular tachycardia (a fast, abnormal heart rhythm) better than others. Researchers will measure blood pressure and blood flow in the heart's arteries during controlled pacing in 70 participants already scheduled for …

This study looks at why people with COPD get very sick from a common cold virus (rhinovirus). Researchers will infect 50 volunteers—some with COPD, some healthy—in a controlled setting. They will compare lung and body responses to find new ways to prevent or treat COPD flare-ups.…

This study will see if artificial intelligence (AI) can plan heart MRI scans as quickly and accurately as expert radiographers. Researchers will recruit 150 adults who are already scheduled for a heart MRI. During the scan, the AI will also plan a duplicate set of images, and doc…

This study creates an online registry for 10,000 adults with cardiomyopathy or myocarditis (heart muscle diseases). Researchers will track health events like heart failure, arrhythmias, and death over time to better understand these conditions. Participants join from home and are…

This UK study follows 90 families of very premature babies (born before 30 weeks) for one year after they leave the hospital. It looks at how a serious bowel condition called NEC affects the baby's health and the family's finances, emotions, and daily life. Parents fill out quest…

This study looks at 100 older adults with normal pressure hydrocephalus (NPH) to find out why some get better after a shunt surgery and others do not. Researchers will use brain scans, blood tests, and wearable monitors to check for nerve damage and signs of dementia. The goal is…

This study looks at whether a low, non-hallucinogenic dose of psilocybin (the active ingredient in magic mushrooms) can make a mental imagery therapy more effective for young people aged 16-25 who self-harm. The therapy, called Imagery Re-Scripting, helps replace upsetting mental…

This study looks at 60 people with stable chest pain (angina) who have two narrowed heart arteries. During a heart catheter procedure, doctors will briefly inflate a tiny balloon inside each blockage while the person exercises on a bike. They measure how much blood flow drops bef…

This study compares regular MRI scans to standard care for men with low-to-medium risk prostate cancer who are on active surveillance. The goal is to see if MRIs can better detect cancer progression over 5 years while reducing the need for PSA tests, biopsies, and clinic visits. …