Imperial College London

This study tests whether an automated insulin delivery system (a smart pump that adjusts insulin automatically) can improve blood sugar control and quality of life in people with type 2 diabetes who are on kidney dialysis. About 84 participants will be randomly assigned to either…

This study tests whether a daily low dose of tadalafil (a drug used for erectile dysfunction) is safe and can help slow memory loss in people with early Alzheimer's or mild cognitive impairment. About 244 participants will take the drug for one year while researchers monitor side…

This study aims to improve a non-invasive breath test for stomach and esophageal cancers. Researchers will collect breath samples from 6,000 adults referred for suspected cancer to see if certain chemicals in the breath can reliably indicate the presence of cancer. The goal is to…

This early-phase trial tests whether maralixibat is safe and can reduce severe itching in pregnant women with intrahepatic cholestasis of pregnancy (ICP), a liver condition that raises bile acids. About 28 women with a single pregnancy between 20 and 35 weeks will take the drug. …

This study will collect heart sound and ECG recordings from 1,000 adults undergoing routine echocardiography. Researchers will use artificial intelligence to analyze these recordings and see how well they can detect pulmonary hypertension and other heart conditions. The goal is t…

This study looks at how gender-affirming hormone therapy changes the immune system in transgender people. Researchers will collect blood samples from 500 adults before and during hormone therapy to track changes in immune cells and proteins. The goal is to understand why men and …