Imperial College London

This study tests whether oral semaglutide, a drug used for diabetes, is safe and can slow Alzheimer's disease. Sixty people with mild Alzheimer's will take the drug for one year. Researchers will check for side effects and use brain scans to see if the drug protects brain cells.

This study tests whether a daily low dose of tadalafil (Cialis), a drug used for erectile dysfunction, is safe and can help slow memory loss in people with early Alzheimer's or mild cognitive impairment. About 244 participants aged 50 and older will take the drug for one year whi…

This study tests whether an automated insulin delivery system can help people with type 2 diabetes and advanced kidney failure on dialysis better control their blood sugar. About 84 participants will be randomly assigned to either the automated system or usual care with a glucose…

This study aims to see if a blood test can help doctors diagnose Alzheimer's disease early, when symptoms are still mild. Researchers will test 1,000 adults aged 55 and older who have memory or thinking concerns. The goal is to find a simple, accurate way to detect Alzheimer's in…

This study tests a new, more sensitive PET/CT scanner (LAFOV) to see if it can detect blood vessel inflammation more clearly in people with large vessel vasculitis. Researchers will compare scans from 18 patients and healthy volunteers to develop a standard imaging protocol. The …

This study aims to improve a non-invasive breath test that detects stomach and esophageal cancers by measuring specific compounds in exhaled breath. Researchers will test 6,000 adults referred for suspected cancer to see if adding simple metabolic substances boosts the test's acc…

This study tests whether modafinil, a drug that promotes wakefulness, can reduce severe fatigue in people with Crohn's disease or ulcerative colitis. About 70 adults with long-term fatigue will receive either modafinil or a placebo for 12 weeks. The main goal is to see if a large…

This early-stage study tests a drug called maralixibat in 28 pregnant women with intrahepatic cholestasis of pregnancy (ICP), a liver condition that causes severe itching and high bile acids. The main goal is to see if the drug is safe and tolerable for both mother and baby. Rese…

This study looks at whether doctors are properly reporting small cancer spots called tumor deposits in people with rectal cancer. These spots can show if the cancer is more aggressive and might need extra treatment like chemo or radiation. Researchers will compare reports from be…

This study will collect heart sound and ECG recordings from 1,000 adults undergoing routine echocardiograms. The goal is to test whether artificial intelligence (AI) can accurately detect pulmonary hypertension and other heart conditions from these recordings. If successful, this…

This small study will look at how changes in the cells lining blood vessels are linked to increased resistance in the lungs of people with pulmonary artery hypertension (PAH). Researchers will measure specific markers in the blood and compare them to lung pressure readings. The g…

This study looks at how much pregnant women know about labour induction before it happens and how that knowledge affects their birth experience. Researchers will also survey doctors and midwives to see how well they understand and explain induction. About 112 people (82 pregnant …

This study will give a small dose of the Omicron EG.5.1 virus to 38 healthy, vaccinated adults aged 18-50 to see how many get a mild infection and how their immune system responds. Participants will stay in quarantine for 10-12 days and be monitored closely. The goal is to create…

This study will compare four different ways of checking up on men after they finish curative treatment for prostate cancer. The goal is to find out which follow-up method is safest, most effective, and makes the best use of NHS resources. Over 100,000 men from hospitals across En…

This study looks at how gender-affirming hormone therapy changes the immune system in transgender people. Researchers will collect blood samples from 500 adults before and during hormone therapy to see how immune cells and responses shift. The goal is to understand why men and wo…