Imperial College London

This study aimed to test the safety of placing insulin-producing cells into the front part of the eye in 6 adults with type 1 diabetes. Participants had to already need immune-suppressing drugs and have poor vision in at least one eye. The study was withdrawn before starting, so …

This study tests a drug called tezepelumab in 42 adults with EGPA, a rare condition that causes inflammation in blood vessels and often leads to asthma and nerve damage. The goal is to see if the drug can help patients achieve remission (no active disease) while taking less stero…

This early-stage study tests the safety of dostarlimab, an immunotherapy drug, in people with HIV-related Kaposi sarcoma that hasn't responded to standard HIV treatment. About 15-20 participants will receive the drug alongside their HIV therapy. The goal is to see if the drug is …

This study aimed to see if the drug capivasertib could clear cancer DNA from the blood of 20 women with ER-positive breast cancer who were already on hormone therapy. The goal was to prevent the cancer from coming back or spreading. However, the study was withdrawn before any par…

This study tests a new treatment for people with advanced high-grade neuroendocrine tumors (a rare and fast-growing cancer). Participants first receive chemotherapy (etoposide and carboplatin) plus an immunotherapy drug (pembrolizumab), followed by a maintenance therapy of pembro…

This study looks at how a drug called XBD173 attaches to a protein called TSPO in the lungs of 16 healthy volunteers. Researchers use PET scans to measure this binding and see how food affects drug levels. The goal is to gather information for future studies on lung diseases like…

This study tests whether sending mailed invitations and providing patient navigators (guides) can increase attendance at liver cancer (HCC) ultrasound screening appointments. About 652 adults with liver cirrhosis or chronic hepatitis B are split into two groups: one gets the extr…

This study tests whether digital tools like smart devices and health apps can help older adults (65+) adopt healthy habits. Researchers will compare two app-based programs to a simple leaflet. The goal is to see if a larger trial is possible and safe, not to prove the tools work.…

This study tests whether a drug called XBD173 can improve blood flow in the brains of people with Alzheimer's disease. About 51 participants will take the drug or a placebo for 28 days and have MRI scans and blood tests. The goal is to see if the drug helps brain blood vessels wo…

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …