New combo aims to boost cancer-killing radiation in hard-to-treat tumors

NCT ID NCT05178693

First seen Nov 25, 2025 · Last updated Jun 16, 2026 · Updated 29 times

Summary

This early-stage study tests whether taking a 5-day course of the drug ASTX727 before standard Lutathera radiation therapy can help the radiation target cancer cells more effectively. About 27 adults with metastatic neuroendocrine tumors will receive the combination. The goal is to see if the priming drug can turn on a receptor that makes cancer cells more visible to the radiation, potentially improving treatment response while monitoring side effects and quality of life.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Hammersmith Hospital

    RECRUITING

    London, London, City of, W12 0HS, United Kingdom

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.