Heart-Healthy supplement may counter painkiller risks
NCT ID NCT04765644
First seen Apr 23, 2026 · Last updated Jun 20, 2026 · Updated 9 times
Summary
This completed study tested whether taking L-arginine, a natural amino acid, could prevent blood vessel damage caused by the painkiller celecoxib. Forty-four healthy men took either celecoxib alone, celecoxib plus L-arginine, or placebos for one week. Researchers measured changes in blood vessel function and stiffness to see if the supplement offered protection.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Imperial College Clinical Research Facility
London, w12 0HS, United Kingdom
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
L-arginine (an amino acid supplement) and celecoxib (an NSAID painkiller)
What this could lead to
If it works, this could point toward a way to reduce heart risks from common painkillers like celecoxib.
What could go wrong
This was a small, early-phase study in only 44 healthy men, so results may not apply to the general public or people with health conditions.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.