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Blow into this tube: a simple breath test might spot liver disease early

NCT ID NCT04620538

First seen Apr 09, 2026 · Last updated Jun 23, 2026 · Updated 15 times

Summary

This study looked at whether a breath test could help detect liver fibrosis, cirrhosis, or liver cancer. Researchers collected breath samples from 56 patients with known or suspected liver disease and analyzed them for specific chemical markers. The goal was to see if the test could accurately tell apart different stages of liver disease without needing a needle or scan.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Imperial College Healthcare Trust

    London, W2 1NY, United Kingdom

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

breath analysis (volatile organic compounds)

What this could lead to

If successful, this breath test could offer a simple, non-invasive way to detect serious liver diseases early, potentially replacing more invasive procedures.

What could go wrong

This is a small, completed study with 56 participants. The test's accuracy is still being evaluated, and it may not be reliable enough for widespread use without further validation.

Conditions

The condition(s) this trial relates to.

cirrhosis of liver Fibrosis fibrotic liver disease hepatocellular carcinoma Liver Neoplasms pediatric hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.