CIRRHOSIS

This study is testing if the blood-thinning medication apixaban is safe and effective at dissolving blood clots that form in a major liver vein more than a year after spleen removal surgery. It involves 20 patients with liver cirrhosis who develop this specific type of clot. Doct…

This small Mayo Clinic study is testing if a dietary supplement made from potato starch can help people with advanced liver disease (cirrhosis) who experience episodes of confusion or brain fog, known as hepatic encephalopathy. Researchers want to see if the starch changes gut ba…

This study is for people with advanced liver scarring (cirrhosis) who have also lost significant muscle mass, a condition called sarcopenia. Researchers want to see if adding a specific nutritional supplement (branched-chain amino acids, or BCAAs) to a standard medical procedure …

This study is testing a new computer software called CirrhosisRx, which is designed to help doctors and nurses follow the best medical guidelines when caring for hospitalized patients with advanced liver scarring (cirrhosis). The goal is to see if using this software leads to bet…

This study is investigating whether a standard medical procedure called TIPS, used to treat complications of advanced liver scarring (cirrhosis), can help the liver partially heal itself—a state called 'recompensation.' Researchers will follow 250 patients with cirrhosis who rece…

This study is testing whether a drug called memantine, commonly used for Alzheimer's disease, can help control advanced liver cancer in patients who also have severe liver scarring (cirrhosis) and are too sick for standard chemotherapy. It will measure if the cancer stops growing…

This study aims to find out if performing a camera scope procedure (endoscopy) urgently within 6 hours is better than waiting 6 to 24 hours for patients with advanced liver disease who have a dangerous bleed from swollen veins in their stomach or esophagus. It will enroll 400 pat…

This small pilot study is testing whether giving copper supplements to people with advanced liver scarring (cirrhosis) is safe and can improve their health. It will involve 30 adult patients who have cirrhosis and low copper levels. Researchers want to see if raising copper level…

This study is testing whether a cholesterol-lowering drug called rosuvastatin can safely slow the progression of liver cirrhosis. It will involve about 256 adults with early-stage cirrhosis who are not yet experiencing severe complications. Participants will take either the drug …

This study is testing if adding the diabetes/heart drug empagliflozin to the standard heart drug carvedilol can better protect people with liver cirrhosis and a stiff heart. The main goal is to see if this combination prevents serious liver complications (like internal bleeding o…

This study is testing if adding a cholesterol-lowering statin drug to standard beta blocker treatment can help control advanced liver disease (decompensated cirrhosis). It will enroll 50 patients who already have serious liver complications. The goal is to see if this combination…

This study is testing if a heart medication called carvedilol can safely lower high blood pressure in the liver's portal vein (portal hypertension) in people with cirrhosis. The goal is to see if this reduces the risk of dangerous digestive bleeding. Researchers will measure the …

This study is testing whether empagliflozin, a medication typically used for diabetes, can help reduce dangerous fluid buildup in the abdomen (ascites) of people with advanced liver scarring (cirrhosis). Researchers will give the drug or a placebo to 20 patients for 14 days to se…

This study is testing a new, potentially safer method to measure pressure inside the liver (portal hypertension) in people with cirrhosis from chronic hepatitis. The goal is to see if this new method, done during a standard scope exam, can accurately predict a patient's risk of s…

This study aims to find out if a newer, endoscopy-based method for measuring pressure in the liver's blood vessels (EUS-PPG) is as accurate as the current standard test (HVPG). Researchers will compare both methods in 40 patients with advanced liver disease who are already schedu…

This study is testing whether adding a quick, 10-minute MRI scan to the standard 6-month ultrasound check can help find liver cancer at its earliest, most treatable stage in people with cirrhosis who are at high risk. Researchers will compare the two approaches in about 944 patie…

This study is testing if a faster, 20-minute MRI scan without dye is better than the standard ultrasound for finding liver cancer early in people with cirrhosis who are at high risk. Researchers will enroll 300 participants to receive both scans every six months for 30 months to …

This study aims to find a better, non-invasive way to measure pressure in the liver for people with cirrhosis. Researchers will compare two types of advanced MRI scans (3D and 2D) to see which one more accurately predicts liver pressure, which currently requires an invasive cathe…

This study is testing whether regular screening can help prevent deaths from liver cancer in people with cirrhosis (scarred liver). About 600 patients in one region of Denmark will get liver ultrasounds and a blood test every six months to try to catch cancer early. Researchers w…

This study is testing whether a low dose of the cholesterol-lowering drug atorvastatin (Lipitor) can reduce the risk of developing liver cancer in people who have advanced liver scarring (fibrosis or cirrhosis). About 60 adults with this high-risk condition will take either the s…

This study aims to find the best screening method to detect liver cancer early in people with cirrhosis. Researchers will compare standard ultrasound with a faster MRI scan, both done every six months, to see which finds cancer sooner. The goal is to catch cancer at earlier stage…

This study is testing whether a small, wearable electrical stimulation device can help reduce chronic pain and depression symptoms in people with cirrhosis. Participants will use the device at home for 10 weeks to see if it's a practical and acceptable treatment option. The main …

This small pilot study is testing whether a virtual sleep therapy program is practical and helpful for people with liver cirrhosis who struggle with insomnia. Researchers will enroll 10 participants to try a telehealth version of cognitive behavioral therapy for insomnia. The mai…

This study aims to understand if bacteria inside the liver are linked to alcoholic hepatitis, a severe liver disease. Researchers will collect and analyze bacteria from the liver, blood, and stool of 50 patients with suspected alcoholic hepatitis. The goal is to learn how these b…

This study aims to understand why some people with fatty liver disease (MASLD) develop serious complications like cirrhosis or liver cancer, while others do not. Researchers will analyze the complete DNA from blood and liver tissue samples of nearly 3,000 participants to look for…

This study aims to understand how a patient's physical strength, nutrition, and mental health before a liver transplant affect their recovery afterward. Researchers will measure frailty, muscle mass, anxiety, and depression in 60 adults waiting for a transplant. The goal is to id…

This study aims to understand how a standard liver procedure (TIPS) might help improve severe muscle loss in people with advanced liver cirrhosis. Researchers will follow 132 patients after their procedure, measuring a specific protein (FGF21) in their blood and tracking changes …

This study aims to understand if leg muscle strength is a good way to measure physical frailty in people with liver cirrhosis. It will compare the muscle strength of 60 patients with cirrhosis to that of healthy volunteers. The goal is to gather knowledge to help doctors better a…

This study aims to understand why people with advanced liver scarring (cirrhosis) often lose significant muscle and fat, a condition linked to worse health outcomes. Researchers will compare small tissue samples taken during surgery from 16 cirrhosis patients and 16 healthy peopl…

This study aims to better understand liver cirrhosis and improve care for patients, including those who receive transplants. Researchers will follow 3000 patients over time, collecting health data and biological samples to identify what factors lead to complications and affect su…

This study aims to understand if low blood sugar at night contributes to severe muscle loss in people with liver cirrhosis. Researchers will monitor 200 participants' blood sugar continuously and measure their muscle mass and strength. The goal is to gather evidence to design bet…

This study aims to understand why people with liver cirrhosis lose muscle mass. Researchers will use a new technique with special tracers and just one muscle biopsy to measure how muscle proteins are built up and broken down. The goal is to gather knowledge that could help develo…

This study aims to understand what factors help or hinder the natural resolution of dangerous blood clots in the main vein of the liver (portal vein) in patients with advanced cirrhosis and swollen veins in their esophagus. Researchers will look back at and follow 1,500 patients …

This study aims to better understand Gastric Antral Vascular Ectasia (GAVE), a condition where blood vessels in the stomach enlarge and can cause pain, nausea, and bleeding. Researchers will measure how often these symptoms occur and how they relate to how well the stomach emptie…

This study aims to understand how a drug called Saroglitazar is processed by the body in people with liver damage caused by a specific type of liver disease. It will compare 30 participants with mild, moderate, or severe liver damage to people with normal liver function. The main…