CIRRHOSIS

This study tests whether a procedure called TIPS (a small tube placed in the liver to improve blood flow) can help people with advanced liver disease (cirrhosis) achieve 'recompensation' — meaning their liver function improves and complications like fluid buildup or bleeding stop…

This study tests whether adding a blood thinner (apixaban) to a standard heart drug (carvedilol) can prevent serious complications like internal bleeding, fluid buildup, and liver failure in people with cirrhosis and high blood pressure in the liver. About 220 adults with stable …

This study tests if bariatric (weight-loss) surgery is more effective than standard medical treatment at making nonalcoholic steatohepatitis (NASH) disappear without worsening liver scarring. It involves 100 obese adults with advanced liver fibrosis. Participants are randomly ass…

This study looks at whether giving copper supplements to people with cirrhosis (scarring of the liver) who have low copper levels can improve liver function and overall health. About 30 adults with cirrhosis and low or borderline copper will take copper or a placebo for a set tim…

This study tests whether adding empagliflozin (a diabetes drug) to standard carvedilol treatment can prevent serious liver complications and death in people with cirrhosis and a stiff heart condition. About 400 adults aged 18-65 with cirrhosis and left ventricular diastolic dysfu…

This study looks at whether the blood thinner apixaban can safely clear blood clots in the portal vein that appear more than a year after spleen removal surgery. It involves 20 adults with cirrhosis who had their spleen removed. The main goal is to see if the clots fully dissolve…

This study tests whether capsules containing gut bacteria from healthy donors can safely reduce alcohol cravings and drinking in 80 adults with alcohol-related liver disease and cirrhosis. Participants will receive either the bacteria capsules or a placebo, and researchers will t…

This study is testing a new surgical approach for people with cirrhosis who need their spleen removed due to an enlarged spleen and high blood pressure in the liver. The surgery uses a nerve (vagus nerve) as a guide to potentially reduce common post-surgery digestive issues like …

This study tests whether empagliflozin, a drug used for diabetes, can help people with cirrhosis (liver scarring) and ascites (belly fluid buildup) get rid of excess salt and water. About 20 adults on stable diuretics will receive either the drug or a placebo for 14 days. The goa…

This study looks at 164 adults with cirrhosis (scarred liver) who also have severe muscle loss (sarcopenia) and need a procedure called TIPS to treat complications like bleeding. Half will get TIPS alone, and half will get TIPS plus branched-chain amino acid (BCAA) supplements. T…

This study looks at whether the blood thinner apixaban can safely dissolve blood clots in the main vein of the liver (portal vein) that appear more than a year after spleen removal surgery. The trial involves 20 adults with cirrhosis who had this surgery. Researchers will measure…

This study tests if memantine, a drug used for Alzheimer's, can help control advanced liver cancer in people with severe cirrhosis. About 12 adults with liver cancer that cannot be surgically removed will take memantine alone. Researchers will track how long the cancer stays stab…

This study tests whether rosuvastatin, a widely used cholesterol medication, can safely slow or prevent liver scarring and complications in people with cirrhosis. Researchers will enroll 256 adults with early-stage cirrhosis from causes like fatty liver, alcohol, or hepatitis. Pa…

This study tests whether adding a statin (atorvastatin) to a standard beta-blocker can help people with decompensated cirrhosis, a serious form of liver disease. About 50 participants will receive either the combination or a beta-blocker plus placebo and be followed for 12 months…

This study tests whether a quick, dye-free MRI scan can find liver cancer earlier than the standard ultrasound in 300 people with cirrhosis who are at high risk. Participants will get both an ultrasound and a short MRI every 6 months for 2.5 years. The goal is to see if the MRI c…

This study compares two ways to screen for liver cancer in people with cirrhosis who are at high risk. About 944 participants will either get a standard ultrasound every six months or an ultrasound plus a quick MRI (Fast-MRI). The goal is to see if adding Fast-MRI finds more earl…

This study tests whether a 3D MRI scan can accurately measure liver scarring and related high blood pressure without needing a needle. About 100 adults with confirmed cirrhosis will get both a 3D and a 2D MRI scan, and results will be compared to the standard pressure measurement…

This study is testing whether offering liver cancer screening every 6 months to people with cirrhosis can reduce deaths from liver cancer. The screening includes an ultrasound and a blood test. About 617 adults aged 40-79 with compensated cirrhosis in one region of Denmark will b…

This study tests whether carvedilol, a drug usually used for heart conditions, can lower high blood pressure in the liver's main vein to prevent dangerous bleeding in people with cirrhosis. About 30 adults with cirrhosis and signs of high liver pressure will take carvedilol for o…

This study tests whether a special MRI scan can find liver cancer earlier than the standard ultrasound in people with cirrhosis. Earlier detection could lead to more effective treatments and lower the chance of dying from liver cancer. The trial will involve 4,700 participants an…

This study tests whether taking atorvastatin (a widely used cholesterol medication) daily for a year can reduce the risk of developing liver cancer in 60 adults with advanced liver fibrosis or cirrhosis. Participants are randomly assigned to receive either atorvastatin or a place…

This study is testing whether a small, non-invasive electrical device (TEA) can help reduce pain and depression in people with cirrhosis. About 30 participants will be randomly assigned to use either the real device or a sham (fake) device. The main goal is to see if the device i…

This study tests a virtual cognitive behavioral therapy program designed to improve sleep for people with cirrhosis who also have insomnia. Ten adults with cirrhosis and sleep difficulties will try the program from home. The goal is to see if the program is practical and well-lik…

This study tests whether weekly infusions of albumin (a protein) can improve thinking and quality of life in people with cirrhosis who have had episodes of hepatic encephalopathy (brain fog). Thirty participants will receive both saline (placebo) and albumin infusions over 8 week…

This study looks at bacteria living in the liver, blood, and stool of people with severe alcoholic hepatitis. Researchers want to see if these bacteria are linked to how well patients respond to treatment and their overall survival. The goal is to find new ways to treat this seri…

This study tests if a new, less invasive method using an endoscope (EUS-PPG) can measure liver blood pressure as accurately as the standard method (HVPG). About 40 adults with liver disease will have both measurements during one session. The goal is to see if the newer method can…

This study looks at whether a special potato starch supplement can change gut bacteria in people with cirrhosis who have had episodes of confusion (hepatic encephalopathy). Eleven participants will take the starch for 4 weeks, and researchers will measure changes in stool and thi…

This early-stage study looks at how the body processes the drug Saroglitazar in people with mild, moderate, or severe liver cirrhosis caused by cholestatic liver disease. About 30 adults aged 18 to 80 will take the drug once daily for 28 days. The goal is to measure drug levels i…

This study tracks 60 people with liver cirrhosis to see how common muscle loss (sarcopenia) is and how it changes over time. Researchers use ultrasound to measure muscle size and a grip test to check strength. They also look at nutrition's role. The goal is to better understand m…

This study is looking at the DNA of 2880 people to find genetic clues about why some people with fatty liver disease develop serious liver damage, cirrhosis, or liver cancer. Researchers will compare the genes of patients with advanced disease to those with risk factors but less …

This study looks at why people with cirrhosis (scarred liver) often lose muscle and fat, which can make them sicker. Researchers will compare tissue samples from 16 cirrhosis patients getting a liver transplant and 16 healthy people having other abdominal surgery. They will measu…

This study looks at whether tiny plastic particles (microplastics and nanoplastics) build up in the liver and worsen cirrhosis and heart problems. Researchers will compare tissue samples from 30 people with cirrhosis to those without liver disease. The goal is to understand how p…

This study looks at how muscle protein is made and broken down in people with cirrhosis, a serious liver condition. Researchers will use special tracers and a single muscle biopsy to measure these processes. The goal is to better understand muscle loss in cirrhosis, which could l…

This study is testing a new, less risky method to measure pressure in the liver's blood vessels using an endoscope with ultrasound. It involves 30 adults with chronic hepatitis and cirrhosis. The goal is to see if this measurement can help predict serious problems like internal b…

This study will follow 3,000 adults with cirrhosis or who have had a liver transplant at a French hospital. Researchers will track survival, complications, and collect samples to learn more about the disease and improve patient care. The goal is to better understand risk factors …

This study looks at whether low blood sugar during the night is connected to muscle loss (sarcopenia) in people with cirrhosis. Researchers will monitor 200 adults with cirrhosis using a continuous glucose monitor and measure muscle mass and strength. The goal is to gather data t…

This study looks at how the autonomic nervous system (which controls automatic body functions) might be linked to liver cancer. Researchers will measure nerve activity and psychological traits in 100 adults with cirrhosis to find new ways to detect liver cancer earlier. The goal …

This study tests a computer program called CirrhosisRx that helps doctors make decisions for hospitalized patients with cirrhosis (liver scarring). About 2,100 adults with cirrhosis will be split into two groups: one where doctors use the tool and one where they follow usual care…

This study looks at how a simple potato starch supplement changes gut bacteria in 30 veterans who have both cirrhosis (liver scarring) and PTSD. Researchers want to see if this natural fiber can improve the balance of good bacteria in the gut, which may help with brain health. Pa…

This study looks at why a procedure called TIPS, which helps lower blood pressure in the liver, may also improve muscle loss (sarcopenia) in people with advanced liver disease. Researchers will measure a protein called FGF21 and muscle mass in 132 adults with cirrhosis before and…

This study looks at people with cirrhosis (scarred liver) who also have a blood clot in the main liver vein and enlarged veins in the stomach. Researchers want to find out what helps these clots dissolve over time. The goal is to help doctors and patients better understand the di…

This study looks at how frailty, nutrition, muscle loss, and mental health affect people waiting for a liver transplant. Researchers will measure physical strength, walking ability, and daily function, along with diet and emotional well-being. The goal is to see which factors pre…

This study looks at 400 people with cirrhosis and sudden bleeding from enlarged veins in the food pipe. It compares getting an emergency scope within 6 hours versus waiting 6 to 24 hours. The goal is to see which timing better prevents repeat bleeding over the next 42 days.

This study aims to learn more about Gastric Antral Vascular Ectasia (GAVE), a condition where stomach blood vessels enlarge and may bleed, causing pain and nausea. Researchers will use questionnaires and a breath test to measure symptoms and stomach function in 30 adults with GAV…