CIRRHOSIS

This study looks at whether giving albumin, a protein, along with standard treatment can lower the chance of re-bleeding and death in people with cirrhosis who have sudden bleeding from veins in the food pipe. About 60 adults aged 18-70 will be split into two groups: one gets alb…

This study tests a new procedure using an endoscopic ultrasound to guide the injection of materials that block part of the spleen's blood supply. The goal is to lower the risk of life-threatening bleeding from enlarged veins in the stomach and esophagus in people with liver cirrh…

This study tests whether artificial intelligence (AI) can spot early signs of liver disease (MASLD or cirrhosis) in people getting a routine heart ultrasound. About 2,000 adults flagged as high-risk by the AI will be followed to see if they get diagnosed and treated faster than u…

This study looks at whether a special ultrasound and a spleen stiffness test can safely measure high blood pressure in the liver (portal hypertension) without a needle. About 107 adults with liver cirrhosis will get both the standard invasive test and the new ultrasound methods. …

This study looks at whether a special 4D MRI scan can safely measure blood flow in the liver, replacing the current invasive needle test. 60 adults with cirrhosis will be scanned and compared to standard pressure measurements. If successful, it could make monitoring and predictin…

This study tests whether capsules made from healthy people's gut bacteria can prevent future episodes of hepatic encephalopathy (a brain condition caused by liver disease) in veterans with cirrhosis. About 162 veterans will take these capsules or a placebo. The goal is to see if …

This study tests whether a digital prehabilitation app (HEAL-ME) combined with creatine and whey protein supplements can help maintain muscle health and reduce frailty in 100 adults with cirrhosis. Participants will use the app and take supplements for at least 3 months. The goal…

This study tests whether bumetanide works better than furosemide for removing excess fluid in adults hospitalized with cirrhosis. About 500 participants will receive one of the two diuretics, and researchers will measure weight loss over the first week. The goal is to find which …

This study looks at how removing the spleen (laparoscopic splenectomy) affects cholesterol and fat levels in people with liver cirrhosis, an enlarged spleen, and hypersplenism. Researchers will follow 30 patients for 2 years after surgery to see if their lipid profiles improve or…

This study follows 30 adults with liver cirrhosis, an enlarged spleen, and hypersplenism who are scheduled for laparoscopic splenectomy (spleen removal surgery). Researchers will measure kidney function before surgery and for 2 years after to see if the surgery helps or harms the…

This study will look back at medical records of 1,600 patients with liver cirrhosis who also have sepsis, a life-threatening infection. Researchers want to see how different treatments, like fluids and antibiotics, affect survival 28 days later. The goal is to find better ways to…

This observational study looks at how lactate, a natural substance, changes gut bacteria and how that might be linked to worsening liver cirrhosis. Researchers will compare 200 people with and without liver disease by measuring lactate in blood, stool, and tissue samples. No trea…